您是不是想找：
-
PotentialTherapeuticGenefortheTreatmentofIschemicDisease:Ad2/Hypoxia-InducibleFactor-1(HIF-1)/VP16EnhancesB-TypeNatriureticPeptideGeneExpress
...tesexpressionofbrainnatriureticpeptide(BNP).Theresultsdefineafunctionalhypoxiaresponsiveelement(HRE)inthepromoterofthehumanBNPgeneanddemonstratethatthisHREisnecessaryforHIF-1/VP16-inducedgeneexpressioninhumancardiomyocytesgrownundernormoxicconditions.Luoetal.alsoshowthataconsensusE-boxDNAbindingsequ...
医源资料库；在线期刊；分子药理学杂志；2006年第68卷第6期 -
CaffeineInhibitsAdenosine-InducedAccumulationofHypoxia-InducibleFactor-1,VascularEndothelialGrowthFactor,andInterleukin-8ExpressioninHypoxicHu
...GF)andinterleukin-8(IL-8)isanessentialfeatureoftumorangiogenesis,andthehypoxia-induciblefactor-1(HIF-1)transcriptionfactorisknowntobeakeyregulatorofthisprocess.Inthisstudy,weinvestigatedtheeffectsofcaffeineonHIF-1proteinaccumulationandonVEGFandIL-8expressioninthehumancoloncancercelllineHT29underhypo...
医源资料库；在线期刊；分子药理学杂志；2007年第69卷第8期 -
中药指纹图谱学体系的构建
...onstructionofthesystemoffingerprintologyoftraditionalChinesemedicineSunGuo-xiang，LuoCui-xia，RenPei-pei，ShiCun-yi，HouZhi-fei(Collegeofpharmacy，ShenyangPharmaceuticalUniversity，Shenyang110016)ABSTRACT:OBJECTIVEToconstructthesystemoffingerprintologyoftraditionalChinesemedicine（TCM），an...
药品天地；专业药学；中药大全；中药指纹图谱 -
ANovelClassofProlylHydroxylaseInhibitorsInducesAngiogenesisandExertsOrganProtectionAgainstIschemia
【摘要】Objective—Hypoxiainduciblefactor(HIF)playsapivotalroleintheadaptationtoischemicconditions.Itsactivityismodulatedbyanoxygen-dependenthydroxylationofprolineresiduesbyprolylhydroxylases(PHD).MethodsandResults—Wediscovered2uniquecompounds(TM6008andTM6089),whichinhibitedPHDandstab...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第12期 -
TubularmitochondrialalterationsinneonatalratssubjectedtoRASinhibition
...nappearstobelessprobablegiventhegreaterresistanceoftheimmaturenephrontohypoxia(8).Furthermore,ifenalapril-inducedhypoxiawastheleadingcauseofmitochondrialdamage,theaberrantmitochondriawouldhavedominatedintheproximaltubules,whichhaverelativelylittleglycolyticcapacity,makingthemdependentonaerobicmitoch...
医源资料库；在线期刊；美国生理学杂志；2006年第289卷第5期 -
Effectsofmaternalmicronutrientsupplementationonfetallossandinfantmortality:acluster-randomizedtrialinNepal
...thms(23).Thesecausesofdeathwereprematurityorseveremalnutritionandbirthasphyxia.Deathwasattributedtoprematurityorseveremalnutritionifthegestationalagewas32wkorthebirthweightwas1.5kg.Deathwasattributedtobirthasphyxiaif1)theinfantdiedwithin7danddidnotcryorcriedweaklyatbirthandwasnotabletobreatheafterbi...
医源资料库；在线期刊；美国临床营养学杂志；2003年78卷第6期 -
Renalmedullarytissueoxygenationisdependentonbothcorticalandmedullarybloodflow
...nmedullarybloodflowismaintained.acuterenalfailure;acutetubularnecrosis;hypoxia;ischemia;laser-Dopplerflowmetry;fluorescenceoximetry;oxygen;rabbits;rats;renalcirculationTHEUNIQUEVASCULARarchitectureofthekidneyallowsdifferentialregulationofcorticalandmedullarybloodflow(7,10,14).Indeed,manyvasoconstric...
医源资料库；在线期刊；美国生理学杂志；2006年第289卷第2期 -
AtheroscleroticAbdominalAorticAneurysmandtheInteractionBetweenAutologousHumanPlaque-DerivedVascularSmoothMuscleCells,Type1NKT,andHelperTC
...inalaorticaneurysmwall.JVascSurg.1994;20:814eC820.GregoryAK,YinNX,CapellaJ,XiaS,NewmanKM,TilsonMD.Featuresofautoimmunityintheabdominalaorticaneurysm.ArchSurg.1996;131:85eC88.HanssonGK,HolmJ,JonassonL.DetectionofactivatedTlymphocytesinthehumanatheroscleroticplaque.AmJPathol.1989;135:169eC175.RekhterM...
医源资料库；在线期刊；循环研究杂志；2005年第95卷第4期 -
AssociationsoftheUCP2GeneLocusWithAsymptomaticCarotidAtherosclerosisinMiddle-AgedWomen
...ncomplexestotheregionencompassingthe–866siteandsuggestedinvolvementofhypoxiainduciblefactor1intheregulationofUCP2geneexpressioninendothelialcellsandmacrophages.Conclusions—OurresultssuggestaroleofUCP2inatherogenesisasoriginallyproposedfromstudiesinanimalandcellculturemodels.Uncouplingprotein2(UC...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第3期 -
HabituationofArousalResponsesafterIntermittentHypercapnicHypoxiainPiglets
....Objectives:Toevaluatewhetherarousaldeficitscanbeinducedbyintermittentasphyxiaduringnormaldevelopment.MethodsandMeasurements:Youngpigletswereexposedtointermittenthypercapnichypoxiafor4daysfromage9.55±0.5days.Arousalresponseswerecomparedbetweencontrolanimalsandanimalsexposedtointermittenthypercapnic...
医源资料库；在线期刊；美国呼吸和危急护理医学；2005年第171卷第6期