Inductionandblockageofoligodendrogenesisbydifferentlyactivatedmicrogliainananimalmodelofmultiplesclerosis
...enerativediseasessuchasmultiplesclerosisiscontroversial.Hereweshowthathigh,butnotlow,levelsofIFN-(acytokineassociatedwithinflammatoryautoimmunediseases)conferredonrodentMGaphenotypethatimpededoligodendrogenesisfromadultneuralstem/progenitorcells.IL-4reversedtheimpediment,attenuatedTNF-production,and...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第4期Chemokines
...ticallydeficientmiceandinsuitablemodels.Aparticularfocusisplacedonthecontributionofplateletchemokinesdepositedonendotheliumformonocytearrest,ondifferencesintheinvolvementofchemokinesbetweenrecruitmenttonativelesionsandtoneointimallesionsafterarterialinjury,andoncloselyrelatedfunctionsofmacrophagemig...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第11期Interleukin-ReceptorTypeIsEssentialforControlofCerebralbutNotSystemicListeriosis
...typemice.Collectively,thesefindingsillustrateacrucialroleofIL-1R1incerebralbutnotsystemiclisteriosis.--------------------------------------------------------------------------------Infectionofthecentralnervoussystem(CNS)byListeriamonocytogenes(LM),agram-positivefacultativeintracellularrod,maycausese...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第3期AlternativeTranslationInitiationofHumanRegulatorsofG-ProteinSignaling-2YieldsaSetofFunctionallyDistinctProteins
...apttochangingsignalingconditions.Consistentwiththismodel,activationofGs/ACVbutnotGqsignalingincreasedtherelativeabundanceofthefull-lengthRGS2protein,suggestingthatalternativetranslationinitiationofRGS2ispartofanovelnegativefeedbackcontrolpathwayforadenylylcyclasesignaling.HeterotrimericG-protein-cou...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第1期IdentificationofaPostendocyticSortingSequenceinCCR5
...unctionalHIV-1receptors.Thedeletionmutantswereinternalizedafterstimulation,buttheylosttheirabilitytorecycletotheplasmamembrane.Theywerereroutedtowardalysosomaldegradativepathway.Weidentifiedhereasequenceoffouraminoacids,presentattheextremeCterminusofCCR5,thatisnecessaryfortherecyclingoftheinternaliz...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第12期RestrictingZap70ExpressiontoCD4+CD8+ThymocytesRevealsaTCellReceptor–dependentProofreadingMechanismControllingtheCompletionofPositiveSelectio
...nbytheadenosinedeaminase(ADA)geneenhancer,whichisactiveinCD4+CD8+thymocytesbutinactiveinCD4+orCD8+single-positive(SP)thymocytes.Insuchmice,terminationofZap70expressionimpairedTCRsignaltransductionandarrestedthymocytedevelopmentaftertheinitiation,butbeforethecompletion,ofpositiveselection.Arrestedthy...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第3期RestrictingZap70ExpressiontoCD4+CD8+ThymocytesRevealsaTCellReceptor–dependentProofreadingMechanismControllingtheCompletionofPositiveSelectio
...nbytheadenosinedeaminase(ADA)geneenhancer,whichisactiveinCD4+CD8+thymocytesbutinactiveinCD4+orCD8+single-positive(SP)thymocytes.Insuchmice,terminationofZap70expressionimpairedTCRsignaltransductionandarrestedthymocytedevelopmentaftertheinitiation,butbeforethecompletion,ofpositiveselection.Arrestedthy...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第3期Phosphoinositide-dependentkinase1targetsproteinkinaseAinapathwaythatregulatesinterleukin4
...3-kinase;PIF,PDK-interactingfragment;PKA,proteinkinaseA;PKAc,PKAcatalyticsubunit;RNAi,RNAinterference;siRNA,smallinterferingRNA.Tcellsplayacriticalroleinnormalimmuneresponsesandinthepathogenesisofmanyautoimmunediseases.Tcellsarenormallyactivatedbysignalsmediatedbytheantigenreceptorandbycostimulatory...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期DeletionofIKK2inhepatocytesdoesnotsensitizethesecellstoTNF-inducedapoptosisbutprotectsfromischemia/reperfusioninjury
...otondo,Italy.AbstractTheinhibitorofNF-B(I-B)kinase(IKK)complexconsistsof3subunits,IKK1,IKK2,andNF-Bessentialmodulator(NEMO),andisinvolvedintheactivationofNF-Bbyvariousstimuli.IKK2orNEMOconstitutiveknockoutmicedieduringembryogenesisasaresultofmassivehepaticapoptosis.Therefore,weexaminedtheroleofIKK2i...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第4期Glucocorticoidsexacerbateobesityandinsulinresistanceinneuron-specificproopiomelanocortin-deficientmice
...onsoftheproopiomelanocortingene(Pomc–/–)causeobesityinhumansandrodents,butthecontributionsofcentralversuspituitaryPOMCdeficiencyarenotfullyestablished.Toelucidatetheseroles,weintroducedaPOMCtransgene(Tg)thatselectivelyrestoredperipheralmelanocortinandcorticosteronesecretioninPomc–/–mice.Rath...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第2期