AThrombospondin-AntagonistofTransformingGrowthFactor-ßActivationBlocksCardiomyopathyinRatswithDiabetesandElevatedAngiotensinII
...ntheinterstitiumandsurroundingthecoronaryarteries.Cardiacfibrosisalsocontributestoleftventricularhypertrophyandisthemajordeterminantofalteredleftventricularcomplianceleadingtosystolicanddiastolicdysfunction.6,7Thefibrogeniccytokinetransforminggrowthfactor(TGF-ß)isknowntoplayasignificantroleinf...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第9期TheAmine-ContainingCutaneousIrritantHeptylamineInhibitstheVolume-RegulatedAnionChannelandMobilizesIntracellularCalciuminNormalHumanEpidermal
...ditions,weisolatedtheVRACcurrent(IVRAC)fromotherconductancesusingahighCa2+-bufferinginternalsolution.IVRACranupafterpatchrupturingandreachedaplateauwithin15min.Itwasreversiblyanddose-dependentlyinhibitedbyheptylaminewithanIC50valueof260µM.Cell-swellingcausedbytheapplicationofahypotonicsolution...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期GlutamateSuppressesOsteoclastogenesisthroughtheCystine/GlutamateAntiporter
...onandbone-resorbingactivitiesinculturedosteoclastsexpressingbothNR1andNR2subunitsrequiredfortheheteromericassemblytofunctionalchannels.25-27Inthesepreviousstudiesusingbonemarrowstromalcells,however,thepossibilitythatfunctionalexpressionofglutamatergicsignalingmoleculesmaybeatleastinpartderivedfromos...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第4期ArylHydrocarbonReceptorActivationProducesHeart-SpecificTranscriptionalandToxicResponsesinDevelopingZebrafish
...includedaclusterofgenesthatweredown-regulated12hafterexposureinhearttissue,butnotinthebodysamples.Morethan70%ofthetranscriptsinthisheart-specificclusterpromotecellulargrowthandproliferation.Thus,thedevelopingheartstandsoutasbeingresponsivetoTCDDatboththeleveloftoxicityandgeneexpression.Thearylhydroc...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期UptakeofLeishmaniamajorbydendriticcellsismediatedbyFcreceptorsandfacilitatesacquisitionofprotectiveimmunity
...ges(M)leadsexclusivelytoMHCclassII–restrictedantigenpresentationtoprimed,butnotnaive,Tcells,andnoIL-12production.Herein,wedemonstratethatuptakeofL.majorbyDCsrequiredparasite-reactiveimmunoglobulin(Ig)GandinvolvedFcRIandFcRIII.Invivo,DCinfiltrationofL.major–infectedskinlesionscoincidedwiththeappe...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期Ferroportin1isrequiredfornormalironcyclinginzebrafish
...rin-receptor–mediatedendocytosis.Erythrocyteshavenoknownmeansofironexportbutratherincorporateironintohemoglobin.Macrophagesserveasironscavengers,phagocytosingsenescenterythrocytes,degradinghemoglobin,andstoringironincorporatedinferritin.Hepcidin,asmallcysteine-richpeptidewithantimicrobialpropertie...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期TheRoleofComplementinInflammatoryDiseasesFromBehindtheScenesintotheSpotlight
...pairofdamagedtissues.However,disturbancesinthis“defensemachinery“contributetothepathogenesisofvariousdiseases.Theroleofcomplementinvariousinflammatorydisordersismultifaceted;forexample,theactivationofcomplementcansignificantlycontributetoinflammation-mediatedtissuedamage,whereasinheritedoracquir...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第9期Anti-CD63antibodiessuppressIgE-dependentallergicreactionsinvitroandinvivo
...M)proteins.Thesignalsinvolvedinthismodulationaremostlyunknownandtheircontributiontoallergicreactionsinvivoisunclear.HerewereportthegenerationofmonoclonalantibodiesthatpotentlysuppressFcRI-induceddegranulation,butnotleukotrienesynthesis.WeidentifiedtheantibodytargetasthetetraspaninCD63.Tetraspaninsar...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期TheBreastCancerResistanceProtein(Bcrp1/Abcg2)LimitsFetalDistributionofGlyburideinthePregnantMouse:AnObstetric-FetalPharmacologyResearchUnit
【关键词】BreastBreastcancerresistanceprotein(BCRP)ismostabundantlyexpressedintheapicalmembraneofplacentalsyncytiotrophoblasts,suggestingthatitmayprotectthefetusbyimpedingdrugpenetrationacrosstheplacentalbarrier.Glyburide(GLB)isanantidiabeticdrugroutinelyusedtotreatgestationaldiabetes.Inthisstu...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期ActivatinganddeactivatingmutationsinthereceptorinteractionsiteofGDF5causesymphalangismorbrachydactylytypeA2
...erg,Germany.7InstitutfürPhysiologischeChemieII,Biozentrum,Universit?tWürzburg,Würzburg,Germany.AbstractHerewedescribe2mutationsingrowthanddifferentiationfactor5(GDF5)thatalterreceptor-bindingaffinities.TheycausebrachydactylytypeA2(L441P)andsymphalangism(R438L),conditionspreviouslyassociatedwithmu...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第9期