LiverXreceptorsregulateadrenalcholesterolbalance
...t-Ferrand,France.AbstractCholesterolistheobligateprecursortoadrenalsteroidsbutiscytotoxicathighconcentrations.Here,weshowtheroleoftheliverXreceptors(LXRandLXR?)inpreventingaccumulationoffreecholesterolinmouseadrenalglandsbycontrollingexpressionofgenesinvolvedinallaspectsofcholesterolutilization,incl...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第7期LipidCompositionAltersDrugActionattheNicotinicAcetylcholineReceptor
...intophosphatidylcholinemembranescontainingtheanioniclipid,phosphatidicacid,buthavenoeffectonthenAChRreconstitutedintomembraneslackingphosphatidicacid,eitherinthepresenceorabsenceofcholesterol.Concentrationsoftetracaineabove200µMleadtoneurotransmittersitebindinginallmembranes.Inthepresenceofpho...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期pUbiquitinBinding-AssociatedDomainMediatedtheReceptorActivatorofNuclearFactor-BLigand-InducedOsteoclastFormation
...,includingparamyxoviralinfectionandputativegeneticfactorsarethoughttocontributetoitsprogression.1,2Morerecently,genomicscansoffamiliesafflictedwithPDBhaveidentified10differentmutationsinthegeneencodingsequestosome1(SQSTM1;alsoknownasp62).Interestingly,allmutationsareeitherclusteredwithin,oradjacentt...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第8期ReducedexpressionofrenalNa+transportersinratswithPTH-inducedhypercalcemia
...smn;6%),type3Na/Hexchanger(NHE3;42±7%),Na-K-ATPase(55±2%),andbumetanide-sensitiveNa-K-2Clcotransporter(BSC-1;25±4%).Incontrast,anupregulationoftheCa2+-sensingreceptor(CaR)wasobserved.Ratstreatedwithmoderate-dosePTHexhibitedunchangedGFRbutdecreasedurinaryconcentration.Thewholekid...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第3期AcyanobacterialLPSantagonistpreventsendotoxinshockandblockssustainedTLR4stimulationrequiredforcytokineexpression
...latoriaPlanktothrixFP1(cyanobacterialproduct[CyP])thatisnotstimulatorypersebutactsasapotentandselectiveantagonistofbacterialLPS.CyPbindstoMD-2andefficientlycompeteswithLPSforbindingtotheTLR4–MD-2receptorcomplex.TheadditionofCyPtogetherwithLPScompletelyinhibitedbothMyD88-andTRIF-dependentpathwaysan...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第6期MicronutrientsandverticaltransmissionofHIV-
...y.Increasedviralsheddinginbreastmilkfrominflammationofbreasttissuemaycontributetoverticaltransmissionthroughbreast-feeding.Lowbirthweightandpretermbirthareriskfactorsfortransmissionduringdeliveryandthebreast-feedingperiod,orconversely,theymaybeconsequencesoftransmissioninutero.Systemicandgastrointes...
医源资料库;在线期刊;美国临床营养学杂志;2002年75卷第6期Grp78isessentialfor11-deoxy-16,16-dimethylPGE2-mediatedcytoprotectioninrenalepithelialcells
【摘要】11-Deoxy-16,16-dimethylPGE2(DDM-PGE2)protectsrenalproximaltubuleepithelialcells(LLC-PK1)againstthetoxicityinducedby2,3,5-tris(glutathion-S-yl)hydroquinone(TGHQ),apotentnephrotoxicandnephrocarcinogenicmetaboliteofhydroquinone.WehavenowdeterminedtheabilityofDDM-PGE2toprotectagainstotherren...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第12期ProtectiveEffectofProteinase-ActivatedReceptorActivationonMotilityImpairmentandTissueDamageInducedbyIntestinalIschemia/ReperfusioninRodents
...atingpeptideSLIGRL-NH2significantlyacceleratedtransitinischemia/reperfusionbutnotinsham-operatedrats.GITwassignificantlydelayedinischemia/reperfusionandsham-operatedPAR2C/CmicecomparedwithPAR2+/+.SLIGRL-NH2significantlyacceleratedtransitinischemia/reperfusioninPAR2+/+butnotinPAR2C/Cmice.Preventionof...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第7期RegulationoftheCYP1A1Geneby2,3,7,8-Tetrachlorodibenzo-p-dioxinbutNotby-Naphthoflavoneor3-MethylcholanthreneIsAlteredinHepatitisCVirusReplic
...thisstudy,wedemonstratethattheinductionofCYP1A1expressioninHuh.8cellsbyTCDDbutnotby-naphthoflavoneor3-methylcholanthrenewassignificantlydiminished.TCDDexposureofHuh.8cellsresultedingreaterthan55%suppressionofCYP1A1transcriptioncomparedwiththeparentcelllineHuh7,whereasproteinlevelsandenzymeactivities...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期InteractionswithFilaminAStimulateSurfaceExpressionofLarge-ConductanceCa2+-ActivatedK+ChannelsintheAbsenceofDirectActinBinding
...iquitousactin-bindingproteinthatformsperpendicularactincross-linksandcontributestochangesincellshape,stiffness,andmotility.AvarietyofmembraneproteinsbindtofilaminA,whichregulatestheirtraffickinginandoutoftheplasmamembrane.FilaminAisthereforebelievedtocouplemembranedynamicswiththoseoftheunderlyingcyt...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第9期