GenotypingofToxoplasmagondiiStrainsfromImmunocompromisedPatientsRevealsHighPrevalenceofTypeIStrains
...pathogenthatcausesseverediseaseinimmunocompromisedpatients.T.gondiihasanunusualclonalpopulationstructureconsistingofthreewidespreadlineagesknownasI,II,andIII.ToestablishthegenotypesofstrainsofT.gondiiassociatedwithhumantoxoplasmosis,wehavedevelopedasetoffourhighlysensitiveandpolymorphicnestedPCRmark...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期Postprandiallipoproteinmetabolismpivotorpuzzle?
...esorCVDandthatitisassociatedwithseveralchangesinthebloodlipoproteinprofile,suchaslowHDL-cholesterolconcentrations,highfastingtriacylglycerolconcentrations,elevatedapolipoproteinC-III,andthepresenceofsmall,denseLDLparticles(2).However,largeprospectivestudiesareneededtoestablishtheindependentpredictiv...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第2期胰岛素促泌剂在2型糖尿病合并冠心病患者中的应用
...及肾脏组织中均有该通道的存在[2]。以磺酰脲受体(SUR)为代表的辅助亚单位与以内向整流钾通道kir6.x为代表的功能亚单位共同构成KATP通道。KATP是由SURx和kir6.x按1∶1构成四聚体的功能单位,即(SURx/kir6.x)×4。SUR感受细胞内A...
资料库;在线期刊;中华现代内科学杂志;2005年第2卷第2期Clinicaltrialsofvitaminandmineralsupplementsforcancerprevention
...lCancerInstitute,NationalInstitutesofHealth,Bethesda,MD,andTheScientificConsultingGroup,Inc,Gaithersburg,MD(DAandSAN)2Presentedattheconference“Multivitamin/MineralSupplementsandChronicDiseasePrevention,“heldattheNationalInstitutesofHealth,Bethesda,MD,May15–17,2006.3SupportedbytheIntramural...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第1期口服降糖药物失效的2型糖尿病患者联合睡前注射中效胰岛素24例疗效观察
...;睡前注射;中效胰岛素 自从第一代磺脲类降糖药(SU)应用于临床以来,不断有新的口服降糖药问世,但是仅仅应用口服降糖药来治疗2型糖尿病,疗效并不令人满意,尤其是接受SU治疗的2型糖尿病患者每年约有5%~10%产生药...
医源资料库;在线期刊;中华现代内科学杂志;2006年第3卷第4期SialylationofHumanThyrotropinReceptorImprovesandProlongsItsCell-SurfaceExpression
...nreceptor(TSHR)hasbeenshowntobeessentialforcorrectproteinfoldingandforcell-surfacetargeting.Inarecentstudy,wedetectedincreasedexpressionof-galactoside(2,6)-sialyltransferase(SIAT1)intoxicthyroidadenomaswheregain-of-functionmutationsoftheTSHRhavebeeninvokedasoneofthemajorcauses.Toinvestigatethephysio...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第4期LiveLongandProsper
...Pharmacology,UniversityofPittsburgh,Pittsburgh,PennsylvaniaAbstractInthisissueofMolecularPharmacology,Meynetal.(p.1320)providetheresultsofthefirstcomprehensiveinvestigationoftheexpressionpatternoftheSrcfamilyofnonreceptortyrosinekinases(SFK)inmouseembryonicstem(ES)cells.Theyfoundthatself-renewingESc...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期急性脑梗死治疗进展
...betterthanbefore.Inthispaper,theprogressoftreatmentonacutecerebralinfarctissummarized.【Keywords】acutecerebralinfarct;thrombolytictherapy;interpositiontreatment脑梗死是神经科的常见疾病,是缺血性脑血管病的严重类型,具有发病率高,复发率高,死亡率高和致...
医源资料库;在线期刊;中华医学实践杂志;2008年第7卷第8期SrcFamilyKinaseActivityIsRequiredforMurineEmbryonicStemCellGrowthandDifferentiation
...aseinhibitor-1induceddifferentiationofEScellsinthepresenceofLIF.Incontrast,suppressionofallSFKactivitywithhigherconcentrationsoftheseinhibitors,orwiththemorepotentcompoundA-419259(BioorgMedChemLett12:1683-1686,2002)blockeddifferentiationinresponsetoLIFwithdrawal.Itissurprisingthattheseinhibitor-trea...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期ImmunofluorescenceAssayforDetectionoftheNucleocapsidAntigenoftheSevereAcuteRespiratorySyndrome(SARS)-AssociatedCoronavirusinCellsDerivedfro
...SARS,earlyidentificationandpromptisolationofcasesisoneofthemostimportantmeasuresforcontrollingthedisease(11,26).Nowadays,variouslaboratorydiagnosticmodalitiessuchasvirusisolation,reversetranscriptase-PCR(RT-PCR),antigendetection,andserologicaltestshavebeendevelopedforthediagnosisofSARS-CoVinfection(...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第5期