硝普钠对内毒素致大鼠急性肺损伤保护作用的机制
...r大鼠随机分为4组(n=8),假手术组(S组)、内毒素组(LPS组)、HO-1诱导剂氯化高铁血红素预处理组(HM组)和硝普钠治疗组(SNP组)。采用气管内滴入750μg/kg(溶于300ml生理盐水中)LPS建立大鼠ALI模型,HM组在给LPS前12h腹腔注射氯化高铁血红素40...
行业资讯;临床快报;呼吸系统相关RenalupregulationofHO-1reducesalbumin-drivenMCP-1production:implicationsforchronickidneydisease
...1).Thepresentstudydeterminedwhethercellularoverexpressionofhemeoxygenase-1(HO-1)caninfluencealbumin-stimulatedMCP-1production.Inresponsetobovineserumalbumin,NRK-52EcellsconstitutivelyoverexpressingHO-1(HO-1OEcells)exhibitlessinductionofMCP-1mRNAandlessproductionofMCP-1proteincomparedwithsimilarlytre...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期a-LipoicAcid–InducedHemeOxygenase-1ExpressionIsMediatedbyNuclearFactorErythroid2-RelatedFactor2andp38Mitogen-ActivatedProteinKinaseinHuman
....E-mailmaria.oconnell@mrc-hnr.cam.ac.ukAbstractObjective—Hemeoxygenase-1(HO-1),therate-limitingenzymeinhemecatabolism,playsaprotectiveroleinthevascularsystem.HO-1inductioninhibitscytokineproductioninmacrophages.AntioxidantsinduceHO-1expressioninvariouscelltypes.-lipoicacid(ALA),athiol-containingdi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第10期ProbingtheExistenceofGProtein-CoupledReceptorDimersbyPositiveandNegativeLigand-DependentCooperativeBinding
...ivecooperativebinding.Becausepositivecooperativebindingcannotbeexplainedwithoutconsideringreceptorasmultivalent,thesebindingdatasupporttheconceptofGPCRdimerizationprocess.Theresults,whichareingoodaccordancewiththepredictionsofpreviousmathematicalmodels,suggestthatbindingexperimentscanbeusedtoprobeth...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期Roleofhemeoxygenase-1inendotoxemicacuterenalfailure
...sCenter,Denver,Colorado2DivisionofCriticalCareNephrology,ChangGuangMemorialHospital,Taipei,TaiwanABSTRACTThepathogenesisofsepticacuterenalfailure(ARF)involvessystemicvasodilationwithcompensatoryupregulationofvasoconstrictors.ThiscanleadtorenalvasoconstrictionandARF.Hemeoxygenase(HO)istherate-limitin...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第12期氯高铁血红素预先给药对感染性休克大鼠心肌损伤的影响
...血一氧化碳血红蛋白(COHb)浓度及心肌血红素氧合酶(HO)-1mRNA、HO-2mRNA及其蛋白的表达。结果与S组比较,H组静脉注射LPS前LVSP和±dp/dtmax差异无统计学意义(P〉0.05);注射LPS后各时点LVSP和±dp/dtmax升高,血浆LDH和CK活性降低,全血COHb...
行业资讯;临床快报;心脑血管相关胆红素在老年冠心病患者诊断中的参考价值
...血清总胆红素(TBL)、直接胆红素(DBIL)、总胆固醇(CHO)、甘油三酯(TG)、高密度脂蛋白(HDL)水平,并进行了对比。结果冠心病组的胆红素水平明显低于健康对照组,P0.05。结论胆红素与老年冠心病呈负相关,而胆红素的...
合作平台;在线期刊;中华中西医杂志;2004年第5卷第1期;其他Hemin-activatedmacrophageshometothepancreasandprotectfromacutepancreatitisviahemeoxygenase-1induction
...entofPediatrics,StanfordUniversity,Stanford,California,USA.4DepartmentofPathology,VAPaloAltoHealthCareSystem,PaloAlto,California,USA.AbstractHeminupregulateshemeoxygenase-1(HO-1),astress-inducedenzymeimplicatedinprotectionfromavarietyofinjurieswhileitsrelatedisoformHO-2isconstitutivelyexpressed.Ther...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第11期血红素氧合酶-1/一氧化碳系统对胰岛素样生长因子-Ⅰ诱导的兔血管平滑肌细胞增殖的抑制作用
...34No.2P.153-15814(贵阳)为了研究血红素氧合酶-1/一氧化碳(HO-1/CO)系统对胰岛素样生长因子-Ⅰ(IGF-Ⅰ)诱导的血管平滑肌细胞(VSMCs)增殖的影响及分子机制。研究者体外培养兔主动脉VSMCs,用IGF-Ⅰ诱导其增殖,用氯化血红素和锌原卟...
行业资讯;临床快报;药理学Hemeoxygenase-1isamodulatorofinflammationandvaso-occlusionintransgenicsicklemice
...ofMinnesota,Minneapolis,Minnesota,USA.2DepartmentofSurgery,HarvardMedicalSchool,BethIsraelDeaconessMedicalCenter,Boston,Massachusetts,USA.AbstractTransgenicsicklemiceexpressing?ShemoglobinhaveactivatedvascularendotheliumthatexhibitsenhancedexpressionofNF-Bandadhesionmoleculesthatpromotevascularstasi...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期