TCellRegulationasaSideEffectofHomeostasisandCompetition
...egulatoryfunctionisalsofoundinthenaivepolyclonalTcellrepertoiredepletedofCD25+Tcells.Tcellscapableofpreventingimmunepathology,likethetransgenicTcells,expresshigherthanaveragelevelsofCD5,anindicatorofavidityforself:MHCpeptidecomplexes.Wethereforeproposethatdysregulatedexpansionofpotentiallypathogenic...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第3期TCellRegulationasaSideEffectofHomeostasisandCompetition
...egulatoryfunctionisalsofoundinthenaivepolyclonalTcellrepertoiredepletedofCD25+Tcells.Tcellscapableofpreventingimmunepathology,likethetransgenicTcells,expresshigherthanaveragelevelsofCD5,anindicatorofavidityforself:MHCpeptidecomplexes.Wethereforeproposethatdysregulatedexpansionofpotentiallypathogenic...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第3期CharacterizationofMycobacteriumcapraeIsolatesfromEuropebyMycobacterialInterspersedRepetitiveUnitGenotyping
...inatedfrom128distinctepidemiologicalsettingsin10countries,spanningaperiodof25years.Wefound78differentMIRUpatterns(53uniquetypesand25clusterswithgroupsizesfrom2to9)butonly17spoligotypes,givingHunter-Gastondiscriminatoryindicesof0.941(MIRUtyping)and0.665(spoligotyping).Forasubsetof103M.capraeisolatesd...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第10期FirstReportedOutbreakofDiarrheaDuetoAdenovirusInfectioninaHematologyUnitforAdults
...lassifiedintosixspecies,AtoF,basedontheirabilitytoagglutinateredbloodcells(25).Mosthumandiseaseisassociatedwithonlyone-thirdoftheknownserotypes.Adenovirusesareassociatedwithvarioussporadictoepidemicinfectionsoftheeyesandrespiratoryandgastrointestinalsystems.Adenovirusescauseinfectionsamongallagegrou...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第6期AbilityofNewAPTIMACTandAPTIMAGCAssaysToDetectChlamydiatrachomatisandNeisseriagonorrhoeaeinMaleUrineandUrethralSwabs
...tedfromenrollmentinthestudyiftheycouldnotconcurrentlyprovideanFCUofthefirst25mlofmicturitionandtwophysician-collectedUSs,iftheyhadurinatedwithin1h,iftheyhadtakenantibioticswithinthelast21days,oriftheycouldnotprovideavalidinformedconsent.PatientswereenrolledfromOctober2002toJanuary2003.Specimencollec...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第1期SusceptibilityofNeisseriameningitidisto16AntimicrobialAgentsandCharacterizationofResistanceMechanismsAffectingSomeAgents
...twodifferentatmospheres.ElevatedpenicillinandampicillinMICs(0.12μg/mland0.25μg/ml,respectively)occurredin14.3%and8.6%ofstrainsandwereassociatedwithpolymorphismsofthepenAgeneencodingamodifiedpenicillin-bindingprotein2.Noneofthe442isolatesproducedbeta-lactamase.Elevatedtetracyclineanddoxycycline(but...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第7期MolecularIdentificationofCapnocytophagaspp.via16SrRNAPCR-RestrictionFragmentLengthPolymorphismAnalysis
...ificationofclinicalbacterialisolates.Amplificationofthe16SrRNAgeneusingPCR(25)allowsgenerationofhighcopynumbersofthisgene,whichmaysubsequentlybeusedforbacterialidentification.CleavageofPCR-generated16SrRNAgeneampliconsbyarestrictionenzyme(s)(RE)resultsindifferentiationbyrestrictionfragmentlengthpoly...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第4期TheinvivopatternofAIDtargetingtoimmunoglobulinswitchregionsdeducedfrommutationspectrainmsh2–/–ung–/–mice
...theycanalsobedetectedingerminalcenterBcellssortedfrommousePeyer‘spatches(25,26).Althoughthemutationloadsinthepreswitchregionareoftenquitelight,aconsiderablyhighermutationloadaccumulatesingerminalcenterBcellsobtainedfrommsh2–/–ung–/–mice(Fig.1A).Theabsenceofbothuracil-DNAglycosylase(UNG)and...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第9期Single-Nucleotide-PolymorphismMappingofthePseudomonasaeruginosaTypeIIISecretionToxinsforDevelopmentofaDiagnosticMultiplexPCRSystem
...gapparatus,andthesecretedtoxins(effectorproteins)andtheircognatechaperones(25).TheeffectorproteinscurrentlydescribedincludetwoADP-ribosylatingenzymes(ExoSandExoT)(13,14,39),anacutecytolyticfactor(ExoU)(11,22),andanadenylatecyclase(ExoY)(40).Thegenesthatencodetheseproteinsarecharacterizedbyvariabletr...
医源资料库;在线期刊;微生物临床杂志;2003年第41卷第8期ImprovementofLymeBorreliosisSerodiagnosisbyaNewlyDevelopedRecombinantImmunoglobulinG(IgG)andIgMLineImmunoblotAssayandAdditionofVlsEandD
...pathogenicEuropeanspecies,B.burgdorferisensustricto,B.afzelii,andB.garinii(25,29-31).Ourpreviousversion(25)incorporatedthefollowing14antigens:p100(B.afzeliistrainPKo),p58(B.gariniistrainPBi),BmpA(B.burgdorferisensustrictostrainB31,PKo,andPBi),VlsE(B.burgdorferisensustrictostrainPKa2),OspC(B31,PKo,PB...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期