NoonanSyndromeMutationQ79RinShp2IncreasesProliferationofValvePrimordiaMesenchymalCellsviaExtracellularSignaleCRegulatedKinase1/2Signaling
theCincinnatiChildren’sHospitalMedicalCenter,DivisionofMolecularCardiovascularBiology,Cincinnati,Ohio.AbstractThemolecularpathwaysregulatingvalvedevelopmentareonlypartiallyunderstood.Recentstudiesindicatethatdysregulationofmitogen-activatedproteinkinase(MAPK)signalingmightplayamajorroleinthepathog...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第10期丹参单体对TNF-α诱导大鼠动脉平滑肌细胞MCP-1和IL-1β的影响
丹参单体对TNF-α诱导大鼠动脉平滑肌细胞MCP-1和IL-1β的影响(pdf)【摘要】目的观察丹酚酸B和丹参酮ⅡA对肿瘤坏死因子(TNF-α)诱导的血管平滑肌细胞(SMC)白细胞介素-1β(IL-1β)和单核细胞趋化蛋白-1(MCP-1)的影响,探讨丹参...
医源资料库;在线期刊;中华现代中医学杂志;2006年第2卷第7期WidespreadDistributionofDisinfectantResistanceGenesamongStaphylococciofBovineandCaprineOrigininNorway
...scohniiandStaphylococcuswarneri,andqacJ(twoisolates)wasfoundinStaphylococcushominisandStaphylococcusdelphinionaplasmid(pNVH01)previouslyfoundinequinestaphylococci.Isolationofindistinguishablepulsed-fieldgelelectrophoresis(PFGE)CoNStypesfromtankmilkandmammaryquartermilksamplesinadairycattleherdsugges...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期水源水中氯苯系化合物卫生检验标准方法
...苯4min53sf.1,2,3,5-四氯苯8min20sg.1,2,4,5-四氯苯9min17sh.1,2,3-三氯苯13min20si.1,2,3,4-四氯苯20min2sj.五氯苯24min1sk.六氯苯45min13s7.结果计算如果用校准曲线定量,按式(1)计算。如果用单个标准定量,按式(2)计算。C=c1×V2/V1×1...
药品天地;专业药学;实验技术;色谱技术;色谱分析实例Identificationofhumanurinarytrefoilfactor1asanovelcalciumoxalatecrystalgrowthinhibitor
...of-flightMSandelectrosprayionization–quadrupole–time-of-flighttandemMSashumantrefoilfactor1(TFF1).Westernblotanalysisconfirmedthemassspectrometricproteinidentification.FunctionalstudiesofurinaryTFF1demonstratedthatitsinhibitorypotencywassimilartothatofnephrocalcin.TheinhibitoryactivityofurinaryT...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第12期DisparaterolesofATRandATMinimmunoglobulinclassswitchrecombinationandsomatichypermutation
...ngland,UK3Dept.ofImmunobiology,King‘sCollegeLondonSchoolofMedicine,Guy‘sHospital,LondonSE19RT,England,UKClassswitchrecombination(CSR)andsomatichypermutation(SHM)aremechanisticallyrelatedprocessesinitiatedbyactivation-inducedcytidinedeaminase.Here,wehavestudiedtheroleofataxiatelangiectasiaandRad3...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期SimpleMethodforDeterminationoftheNumberofHelicobacterpyloriCagAVariable-RegionEPIYATyrosinePhosphorylationMotifsbyPCR
...ableregionoftheprotein.StrainspossessingCagAwithgreaternumbersoftheserepeatshavebeenmorecloselyassociatedwithgastriccarcinogenesis.PhosphorylatedCagAleadstoepithelialcellelongation,whichisdependentonthenumberofvariable-regionEPIYAmotifs.Thus,determinationofthedegreeofCagAphosphorylationandthenumbero...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第2期胺碘酮致尖端扭转性室速1例报告
...置,Q-T0.57s(见图1),查血钾2.8mmol/L,转入CCU病房,给予补钾、扩冠,继续口服胺碘酮0.2g3次/日治疗,转入后第2日(8月15日)患者再发晕厥,心电示波:Q-T间期0.65s~0.76s,继而呈现尖端扭转性室速(Tdp)(见图2),予同步直流...
合作平台;在线期刊;中华现代临床医学杂志;2004年第2卷第6B期Anautosomaldominantmajorgeneconferspredispositiontopulmonarytuberculosisinadults
...umanGeneticsandMedicine,McGillUniversity,MontrealGeneralHospital,Montreal,PQ,H3G1A4Canada3LaboratoryofHumanGeneticsofInfectiousDiseases,InstitutNationaldelaSanteetdelaRechercheMedicaleU550;9UniversityofParisReneDescartes,NeckerMedicalSchool,Paris,75015France4CentreforTuberculosisDiagnosis,HayMohamma...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期DiscoveryofaNovelShp2ProteinTyrosinePhosphataseInhibitor
【关键词】DiscoveryShp2isanonreceptorproteintyrosinephosphatase(PTP)encodedbythePTPN11gene.Itisinvolvedingrowthfactorinducedactivationofmitogen-activatedprotein(MAP)kinasesErk1andErk2(Erk1/2)andhasbeenimplicatedinthepathogenicityoftheoncogenicbacteriumHelicobacterpylori.Moreover,gain-of-functio...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期