非受体蛋白酪氨酸激酶Tec家族的研究进展
...t、Tec、Txk和Bmx,其结构具有高度同源性,均由PH结构域、SH3、SH2及激酶结构域组成,其N端缺乏疏水性跨膜结构,而C端缺乏负性调节区。它们所介导的信号转导主要在免疫细胞的分化、发育、增殖和凋亡过程中起着重要的作用。...
合作平台;医学论文;临床医学与专科论文;检验医学ReactiveOxygenSpeciesandp38Mitogen-ActivatedProteinKinaseActivateBaxtoInduceMitochondrialCytochromecReleaseandApoptosisinResponsetoMalona
...oxintostudyneurodegenerationinHuntington‘sdiseaseandischemicstroke.Wehaveshownpreviouslythatmalonateincreasedreactiveoxygenspecies(ROS)productioninhumanSH-SY5Yneuroblastomacells,leadingtooxidativestress,cytochromecrelease,andapoptoticcelldeath.Expressionofagreenfluorescentprotein-Baxfusionproteini...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期CystamineandcysteamineincreasebrainlevelsofBDNFinHuntingtondiseaseviaHSJ1bandtransglutaminase
...mineisacandidatedrug;however,themechanismsbywhichitoperatesremainunclear.WeshowherethatcystamineincreaseslevelsoftheheatshockDnaJ-containingprotein1b(HSJ1b)thatarelowinHDpatients.HSJ1binhibitspolyQ-huntingtin–induceddeathofstriatalneuronsandneuronaldysfunctioninCaenorhabditiselegans.Thisneuroprote...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期NeuropeptideFF(NPFF)AnalogsFunctionallyAntagonizeOpioidActivitiesinNPFF2Receptor-TransfectedSH-SY5YNeuroblastomaCells
...mofthecellularantiopioidactivityofneuropeptideFF(NPFF),wehavetransfectedtheSH-SY5Yneuroblastomacellline,whichexpressese?and-opioidreceptors,withthehumanNPFF2receptor.Theselectedclone,SH2-D9,expressedhigh-affinityNPFF2receptorsinthesamerangeorderase?and-opioidreceptors(100eC300fmol/mgofprotein).TheNP...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第3期胺碘酮致尖端扭转性室速1例报告
...置,Q-T0.57s(见图1),查血钾2.8mmol/L,转入CCU病房,给予补钾、扩冠,继续口服胺碘酮0.2g3次/日治疗,转入后第2日(8月15日)患者再发晕厥,心电示波:Q-T间期0.65s~0.76s,继而呈现尖端扭转性室速(Tdp)(见图2),予同步直流...
合作平台;在线期刊;中华现代临床医学杂志;2004年第2卷第6B期MolecularIdentificationofMumpsVirusGenotypesfromClinicalSamples:StandardizedMethodofAnalysis
...s,ArgentinaABSTRACTAsensitivenestedreversetranscription-PCRassay,targetingashortfragmentofthegeneencodingthesmallhydrophobicprotein(SHgene),wasdevelopedtoallowrapidcharacterizationofmumpsvirusinclinicalsamples.ThesensitivityandspecificityoftheassaywereestablishedusingrepresentativegenotypesA,B,C,D,E...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第4期MTA1在化疗后骨肉瘤中的表达及其与预后的关系
...eflecttheinvasive,metastaticbiologicalactivitiesoftheresidualtumorcells.ItishelpfultodetectMTA1expressionfortheprognosisofpatientswithosteosarcoma. Keywords:osteosarcoma;neoadjuvantchemotherapy;MTA1;prognosis 肿瘤转移相关基因1(metastasisassociated1,MTA1)是新近发现的一个...
医源资料库;在线期刊;中国矫形外科杂志;2009年第17卷第3期STAT3的作用与肿瘤
...有特异性针对活性IFN-γ回文序列(GAS)元件的序列;(3)SH3结构域:位于第500~600位氨基酸,能与富含Pro的基序(motif)结合;(4)SH2区:参与受体恢复和STAT的二聚体化;(5)C-末端转录激活结构域:在转录激活域内的色氨酸(S727)或...
合作平台;在线期刊;中华实用医药杂志;2004年第4卷第14期;综述第四节 G蛋白和磷脂酶C
...细胞极化(polarization)和抗原的提呈。某些信号蛋白通过SH-3功能区将酪氨酸激酶途径同一些由小G蛋白所控制的途径连接起来,如Rho(与Ras有30%同源性)调节胞浆中微丝上肌动蛋白的聚合或解离,从而影响细胞形态。这一事实解...
医源资料库;医源图书馆;教材类;细胞和分子免疫学FunctionalinfluenceofN-glycosylationinOCT2-mediatedtetraethylammoniumtransport
...nceglycosylationhasonOCT2function,remainsunknown.Toaddresstheseissues,theacquisitionofN-glycosylationwasdisruptedbymutatingtheaminoacidasparagine(N)toglutamine(Q)atthesesitesintherabbitorthologofOCT2,whichwasexpressedinChinesehamsterovarycells.DisruptionofN-glycosylationfollowedbyWesternblottingindi...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期