CDIdentifiesPerivascularMacrophagesinNormalandViralEncephaliticBrainsandPotentialPrecursorstoPerivascularMacrophagesinBlood
...odeficiencyvirus(HIV)encephalitis(SIVEandHIVE).6-13BecausetherelativecontributionofperivascularmacrophagesandparenchymalmicrogliadiffersinnormalCNSphysiologyanddiseaseprogression,phenotypicandfunctionaldifferentiationbetweenthesetwobrainmacrophagesbecomesimportant.Theratmacrophage-associatedantigenE...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第3期SubunitCompositionofNicotinicReceptorsinMonkeyStriatum:EffectofTreatmentswith1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineorL-DOPA
...nctions,immunoprecipitationandligandbindingstudiesweredonetoidentifytheirsubunitcomposition.Asintherodent,2,4,6,2,and3nAChRsubunitimmunoreactivitywasidentifiedinmonkeystriatum.However,distinctfromtherodent,thepresentresultsalsorevealedthenovelpresenceof3nAChRsubunit-immunoreactivityinthissameregion,...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第1期InhibitionofCXCLAttenuatesInflammatoryandProgressivePhasesofAnti-GlomerularBasementMembraneAntibody-AssociatedGlomerulonephritis
...6orpcDNA3GFPplasmidalone.After24hours,cellswerewashedtwotimeswithphosphate-bufferedsalineandthenfixedfor30minutesonicein4%formaldehydeinPEMbuffer(80nmol/LpotassiumPIPES,pH6.8,5mmol/Lethyleneglycolbis(ß-aminoethylether)-N,N,N‘,N‘-tetraaceticacid,pH7.0,and2mmol/LMgCl2).Afterfixation,cellswer...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期CriticalroleofendothelialCXCR2inLPS-inducedneutrophilmigrationintothelung
...solizedbacterialLPSinhalationinducedPMNrecruitmenttothelunginwild-typemice,butnotinlittermateCXCR2–/–mice.Surprisingly,lethallyirradiatedwild-typemicereconstitutedwithCXCR2–/–BMstillshowedabout50%PMNrecruitmentintobronchoalveolarlavagefluidandintolunginterstitium,butCXCR2–/–micereconstit...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期KupfferCell-DependentHepatitisOccursduringInfluenzaInfection
...nfectioninhumanshasbeenassociatedwithincreasedserumaminotransaminaselevels,buttheincidenceofthiseffectandtheetiologyunderlyingtheliverdamagehavenotbeeninvestigated.1-3Immune-mediatedhepatitishasbeenstudiedindifferentmousemodels;however,mostoftheseexperimentalsystemsemploytoxins,hepatotrophicpathogen...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期Theplasminogenactivatorsystemmodulatessympatheticnervefunction
...synaptosomesandculturedneuroblastomacells;thiswasaplasmin-independenteffectbutwaspotentiatedbyafibrinogencleavageproduct.Notably,heartsfromt-PA–nullmicereleasedmuchlessNEuponEFSthantheirwild-type(WT)controls(i.e.,a76.5%decrease;P0.01),whereasheartsfromplasminogenactivatorinhibitor-1(PAI-1)–nullm...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第9期High-ThroughputScreeningforSmall-MoleculeActivatorsofNeutrophils:IdentificationofNovelN-FormylPeptideReceptorAgonists
...anddefinedatleasttwogroupsofactivatorsofROSproductioninmurineneutrophils:t-butylbenzeneandthiophene-2-amide-3-carboxylicesterderivatives.Furtherstudiesoftheactivecompoundsrevealed11compoundsthatactivatedROSproductioninhumanneutrophils,andsixofthesecompoundsalsoactivatedintercellularCa2+mobilizationa...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第4期Caspasesandcalpainareindependentmediatorsofcisplatin-inducedendothelialcellnecrosis
...yandSmac/DIABLOprotein.Calpainactivityincreasedsignificantlywith50µM,butnot10µMcisplatinat24h.With50µMcisplatin,ATPlevelsweresignificantlyreducedstartingat18h,caspase-2-andcaspase-3-likeactivitiesweresignificantlyincreasedstartingat18h,andLDHreleasestartedat8hwithmaximumincreaseat1...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第9期GeneExpressionChangesduringtheDevelopmentofAcuteLungInjuryRoleofTransformingGrowthFactor
...cessesinmultipleorgansystems(3).Oftheseisoforms,TGF-1isgeneratedingreatestabundancesubsequenttotissuedamage(4).TGF-hasbeenwidelystudiedforitsvitalroleinthedevelopmentoffibrosisafterinjurytothelung(5,6).AbroaderfunctionforTGF-issuggestedfromevidencethatelevatedlevelsofTGF-1(aswellasTGF-–induciblege...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第12期Galectin-AssociateswiththePrimaryCiliumandModulatesCystGrowthinCongenitalPolycysticKidneyDisease
...hologicalprocessesinrenalcollectingducts:galectin-3isexpressedintheuretericbud/collectingductlineageduringnephrogenesis,modulatescollectingductgrowth/differentiationinvitro,andisexpressedinhumanautosomalrecessivepolycystickidneydiseaseincystepithelia,almostallofwhicharisefromcollectingducts.Moreover...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期