Capacitativeand1-Oleyl-2-acetyl-sn-glycerol-ActivatedCa2+EntryDistinguishedUsingAdenylylCyclaseType8
...dates.Becausehumanembryonickidney(HEK)293cellsendogenouslyexpresstheseTRPsubunits,thiscelllineissuitableforinvestigatingwhetherDAG-activatedTRPsubunitsformpartoftheputativemultimericassembliesthatmediateCCE.Adenylylcyclasetype8(AC8)isactivatedbyCCEinnonexcitablecellsbutisnotresponsivetootherformsofC...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期TCellRegulationasaSideEffectofHomeostasisandCompetition
...esoleresponsibilityofaspecializedsubsetofTcellsdedicatedtoimmuneregulation,butalsoasideeffectofnormalcompetitionforsharedresourceswithinanintactimmunesystem.Hereweshowthatregulatoryactivityiscorrelatedwithhighhomeostaticexpansionpotential,reflectingtheavidityforself-peptide:MHCcomplexes.Monoclonaltr...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第3期TCellRegulationasaSideEffectofHomeostasisandCompetition
...esoleresponsibilityofaspecializedsubsetofTcellsdedicatedtoimmuneregulation,butalsoasideeffectofnormalcompetitionforsharedresourceswithinanintactimmunesystem.Hereweshowthatregulatoryactivityiscorrelatedwithhighhomeostaticexpansionpotential,reflectingtheavidityforself-peptide:MHCcomplexes.Monoclonaltr...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第3期AninversioninvolvingthemouseShhlocusresultsinbrachydactylythroughdysregulationofShhexpression
...reabletodemonstrateaninversioncomprising11.7Mb.Thedistalbreakpointis13.298kbupstreamofShh,separatingthecodingsequencefromseveralputativeregulatoryelementsidentifiedbyinterspeciescomparison.TheinversionresultsinalmostcompletedownregulationofShhexpressionduringE9.5–E12.5,explainingthehomozygouspheno...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第4期CorticalGlutamatergicNeuronsMediatetheMotorSedativeActionofDiazepam
...knockoutmiceshowgreatermotorsedationwithdiazepam.Toclarifythisparadox,attributedtocompensatoryup-regulationofthe2and3subunits,andtofurtheridentifytheneuronalcircuitssupportingdiazepam-inducedsedation,wegeneratedEmx1-cre-recombinase-mediatedconditionalmutantmice,selectivelylackingthe1subunit(forebrai...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期ApigeninInhibitsImmunostimulatoryFunctionofDendriticCells:ImplicationofImmunotherapeuticAdjuvant
...gen-activatedproteinkinase,thenucleartranslocationofitsnuclearfactor-Bp65subunit,andtheinductionoftheT-helper1responsewereallimpairedinthepresenceofapigenin,whereasthecell-mediatedimmuneresponseremainednormal.Thesefindingsprovidenewinsightintotheimmunopharmacologicalfunctionsofapigeninanditseffectso...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期Amino-PyrrolidineTricarboxylicAcidsGiveNewInsightintoGroupIIIMetabotropicGlutamateReceptorActivationMechanism
...eceptorsubtypes.Accordingtotheirsequencesimilarityandtransductionmechanism,butalsotheirpharmacology,theeightmGlureceptorshavebeenfurtherclassifiedintothreegroups(PinandAcher,2002).GroupIIImGlureceptors(i.e.,mGlu4,-6,-7,and-8subtypes)arecoupledtopertussistoxin-sensitiveGiand/orGoG-proteinsandareactiv...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期ProductionofHerpesBVirusRecombinantGlycoproteinsandEvaluationofTheirDiagnosticPotential
...agnosticpotentialofrecombinantBvirusglycoproteinsforthedetectionofimmunoglobulinG(IgG)antibodiesinmonkeyandhumansera.GlycoproteinsB,C,andEandsecreted(sgG)andmembrane-associated(mgG)segmentsofglycoproteinG(gG)wereexpressedinthebaculovirusexpressionsystem,whilegDwasexpressedinCHOcells.Wedevelopedrecom...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第2期Nutritioninpregnancy:mineralandvitaminsupplements
...nts.Multiplemicronutrientsareoftentakenbypregnantwomenindevelopedcountries,buttheirbenefitsarelimited,exceptforprophylacticfolicacidtakenduringthepericonceptionalperiod.Womenindevelopingcountriesmaybenefitfrommultiple-micronutrientprophylaxisinpregnancy,buttheunderlyingbasisandrationaleforchangingfr...
医源资料库;在线期刊;美国临床营养学杂志;2000年72卷第1期SmallMoleculeDisruptionofGProteinβSubunitSignalingInhibitsNeutrophilChemotaxisandInflammation
【关键词】SmallGproteinβsubunit-dependentsignalingisimportantforchemoattractant-dependentleukocytechemotaxis.Selectivesmallmoleculetargetingofphosphoinositide3-kinase(PI3-kinase)catalyticactivityisatargetofinterestforanti-inflammatorypharmaceuticaldevelopment.Inthisstudy,weexaminedwhethers...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期