SevereSepsisExacerbatesCell-MediatedImmunityintheLungDuetoanAlteredDendriticCellCytokineProfile
...cmiceatdays8and16afterS.mansonieggchallengeexhibiteddefectiveIL-12synthesisbutenhancedIL-10synthesisafterToll-likereceptoragonistchallenge.PulmonarytransfectionwithanIL-12-expressingadenovirusinpostsepticmicereversedtheskewingofthepulmonarycytokineprofileandnormalizedthelunggranulomatousresponse.Our...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第6期色谱固定相研究进展
...为一种反相色谱基质与常规反相色谱基质的选择性不同。Buszewki等比较了烷基胺和烷基键合相基质用于反相分离,发现前者对分离极性化合物效果显著,但其热稳定性不如后者。Wongyai用苯丙醇胺键合到硅胶上产生离子交换—...
医源资料库;在线期刊;中华实用医药杂志;2008年第8卷第10期-wProtectsHippocampusduringExperimentalStatusEpilepticus
...pilepsy.Bcl-2familyproteinsarecriticalregulatorsofmitochondrialdysfunction,buttheirsignificanceinthissettingremainsprimarilyuntested.Presently,weinvestigatedthemitochondrialpathwayandroleofanti-apoptoticBcl-2proteinsusingamousemodelofseizure-inducedneuronaldeath.Statusepilepticuswasevokedinmicebyint...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第10期FocalAdhesionKinaseandProteinKinaseBCooperatetoSuppressDoxorubicin-InducedApoptosisofBreastTumorCells
...9;McFalletal.,2001).Thesesurvivalsignalsmayconferresistancenotonlytoanoikisbutalsotoapoptosisinducedbyanticancerdrugsduetoanoverlapinsignalingpathwaysthatcontrolcelldeath.Indeed,adhesiontoECMproteinsviatheβ1integrinsubunitprotectedsmallcelllungcancercellsagainstdoxorubicin-andetoposide-induceda...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期Relaxin-3/Insulin-LikePeptide5ChimericPeptide,aSelectiveLigandforGProtein-CoupledReceptor(GPCR)135andGPCR142overLeucine-RichRepeat-Containing
...arepredominantlyexpressedinthebrain(Matsumotoetal.,2000;Bathgateetal.,2002;Burazinetal.,2002;Liuetal.,2003b)andarehighlyconservedamongspeciesfromfishtohumans(Bathgateetal.,2002;Hsuetal.,2003;Liuetal.,2003b;Chenetal.,2005),suggestingthatthisligand/receptorpairmayplayanimportantroleinthecentralnervous...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第1期MolecularmechanismsofenhancedrenalcelldivisioninprotectionagainstS-1,2-dichlorovinyl-L-cysteine-inducedacuterenalfailureanddeath
...edchangefrombaselinerenalfunctionmanifestedaselevationsinbloodureanitrogen(BUN)levels,serumcreatinine,andadecreaseinurineoutput(38,39,56,60,63).TheincidenceofARFhasrangedfrom0.15to25%inrecentstudiesanditsincidenceincriticallyillpatientshasrangedfrom4to8%(48,56).Also,withadvancingage,lossofrenalfunct...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第7期MicroparticlesofHumanAtheroscleroticPlaquesEnhancetheSheddingoftheTumorNecrosisFactor-ConvertingEnzyme/ADAMSubstratesTumorNecrosisFactorand
...07TACE/ADAM17+MPs/mgofplaquesisolatedfrom25patientsundergoingendarterectomybutnoneinhealthyhumaninternalmammaryarteries.PlaqueMPsharboredmainlymatureactiveTACE/ADAM17anddosedependentlycleavedapro-TNFmimeticpeptide,whereasapreferentialTACE/ADAM17inhibitor(TMI-2)andrecombinantTIMP-3preventedthiscleava...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第11期Geneticcausesofhumanheartfailure
...reassociatedwithconsiderablesocialandeconomiccosts.In2003heartfailurecontributedtoover280,000deathsandaccountedfor17.8billionhealthcaredollars(1).Heartfailureisacomplexpathophysiologicstateinwhichdeliveryofbloodandnutrientsisinadequatefortissuerequirements.Heartfailurealmostuniversallyarisesinthecon...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第3期PlateletAdhesionReceptorsandTheirLigandsinMouseModelsofThrombosis
...nhasbeenconfirmedandfurtherclarified.Theirabsenceleadstohighlyimpairedthrombusformation,independentofthemodelusedtoinducevascularinjury.Incontrast,therelativecontributionofotherreceptors,suchasglycoproteinVI,orofvariousplateletligandsmayberegulatedbytheseverityofinjury,thetypeofvesselinjured,andthes...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第4期OpioidReceptorHomo-andHeterodimerizationinLivingCellsbyQuantitativeBioluminescenceResonanceEnergyTransfer
...ofPharmacology,SchoolofMedicineandPublicHealth,TheOhioStateUniversity,Columbus,OhioAbstractOpioidreceptorshavebeenshowntodimerizeoroligomerizeamongthemselvesandeachother,affectingtheirfunctionalproperties.Thisstudyusedbioluminescenceresonanceenergytransfer(BRET)betweenthee?,andopioidreceptorstostudy...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第6期