Down-RegulationofDNATopoisomeraseIILeadstoProlongedCellCycleTransitinG2andEarlyMPhasesandIncreasedSurvivaltoMicrotubule-InteractingAgent
...mistry,GdanskUniversityofTechnology,Gdansk,Poland(A.S.,M.S.)AbstractMicrotubulebindersarecellcycle-specificagentswithpreferentialcytotoxicitytowardmitoticcells.Wehavecharacterizedvincristine-selectedhumanleukemiacellstoestablishwhetherdevelopmentofvincristineresistancewasaccompaniedbychangesincellcy...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第3期Dioxin-MediatedUp-RegulationofArylHydrocarbonReceptorTargetGenesIsDependentontheCalcium/Calmodulin/CaMKIPathway
...akentogether,thesedataidentifiedtheCa2+/CaM/CaMKIpathwayasanimportantcontributingfactortoAhR-mediatedgenomicresponse.Thearylhydrocarbonreceptor(AhR)isahelix-loop-helixtranscriptionfactoractivatedbyendogenousligandsandxenobioticssuchastheenvironmentalcontaminant2,3,7,8-tetrachlorodibenzo-p-dioxin(TCD...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide(CPPHA)ActsthroughaNovelSiteasaPositiveAllostericModulator
...V/mGluR5)thatreducesbindingofligandstotheMPEPsiteeliminatestheeffectofVU-29buthasnoeffectontheresponsetoCPPHA.Ontheotherhand,amutation(F585I/mGluRs)thateliminatestheeffectofCPPHAdoesnotaltertheresponsetoVU-29.CPPHAisalsoaPAMatmGluR1.ItisinterestingthatthecorrespondingmutationofF585I/mGluR5inmGluR1(F...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期Long-termtreatmentwithcyclosporinedecreasesaquaporinsandureatransportersintheratkidney
...nurineconcentrationwasobservedinVH-andCsA-treatedrats.ToxiceffectsofCsAontubularcellsinthemedullaaswellasthecortexwereevaluatedwithaldosereductase(AR),Na-K-ATPase-1expression,andbydeterminingthenumberofterminaltransferase-mediateddUTPnickend-labeling(TUNEL)-positivecells.Long-termCsAtreatmentincreas...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第7期BoneMorphogeneticProteinsinVascularCalcification
...pathwaystowardcalcificationmaydifferbetweenthetypesofvascularcalcification,butexaminationofcalcifiedvesselshasrevealedmanysimilaritiesbetweenintimalandtunicamediacalcification.Recently,examinationofcalcifiedvesselsinhumansandanimalsrevealedtheexpressionoftheosteoblasttranscriptionfactorsRunx2/Cbfa1,...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第7期MultilocusSequenceTypingofStreptococcusuberisProvidesSensitiveandEpidemiologicallyRelevantSubtypeInformationandRevealsPositiveSelectioninthe
...emblingS.parauberis;and(iv)horizontalgenetransferandpositiveselectioncontributetoevolutionofcertainS.uberisgenes,suchasthevirulencegenepauA.INTRODUCTIONStreptococcusuberisisamajorcauseofbovinemastitisaroundtheworld(2,29,36,38,56).Udderinfectionscanresultfromthecow-to-cowspreadofthepathogen(38,56)or,...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第5期HumanGuanylateBindingProtein-IsaSecretedGTPasePresentinIncreasedConcentrationsintheCerebrospinalFluidofPatientswithBacterialMeningitis
...ron--inducedfactors.Interestingly,hGBP-1wasonlysecretedfromendothelialcellsbutnotfromanyoftheninedifferentcelltypestested.Clinicallymostimportantwasthedetectionofsignificantly(P<0.001,Mann-WhitneyU-test)increasedhGBP-1concentrationsinthecerebrospinalfluidofpatientswithbacterialmeningitis(n=32)ascomp...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期CD4+CD25+TRCellsSuppressInnateImmunePathologyThroughCytokine-dependentMechanisms
...+regulatoryT(TR)cellscaninhibitavarietyofautoimmuneandinflammatorydiseases,buttheprecisemechanismsbywhichtheysuppressimmuneresponsesinvivoremainunresolved.Here,wehaveusedHelicobacterhepaticusinfectionofTcell–reconstitutedrecombination-activatinggene(RAG)-/-miceasamodeltostudytheabilityofCD4+CD25+T...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第1期Anti-A?42-andanti-A?40-specificmAbsattenuateamyloiddepositioninanAlzheimerdiseasemousemodel
...ivetargetingofA?42orA?40maybeaneffectivestrategytopreventamyloiddeposition,butmayhavelimitedbenefitinatherapeuticsetting.IntroductionItishypothesizedthattheprocesswherebyamyloid?(A?)isaccumulatedasamyloidtriggersthecomplexpathologicalchangesthatultimatelyleadtocognitivedysfunctioninAlzheimerdisease(...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第1期CD4+CD25+TRCellsSuppressInnateImmunePathologyThroughCytokine-dependentMechanisms
...+regulatoryT(TR)cellscaninhibitavarietyofautoimmuneandinflammatorydiseases,buttheprecisemechanismsbywhichtheysuppressimmuneresponsesinvivoremainunresolved.Here,wehaveusedHelicobacterhepaticusinfectionofTcell–reconstitutedrecombination-activatinggene(RAG)-/-miceasamodeltostudytheabilityofCD4+CD25+T...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第1期