Useofphospho-specificantibodiestodeterminethephosphorylationofendogenousNa+/H+exchangerNHE3atPKAconsensussites
...eroneorbothofthesesitesisactuallyphosphorylatedinendogenousNHE3inproximaltubulecellsisunknown.ThepurposeofthisstudywastogeneratephosphospecificantibodiessothatthestateofphosphorylationoftheseserineresiduesinendogenousNHE3couldbeassessedinvitroandinvivo.Tothisend,polyclonalandmonoclonalphosphospecifi...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第9期Physiologicalsignificanceofhypotonicity-inducedregulatoryvolumedecrease:reductioninintracellularCl-concentrationactingasanintracellularsignal
...tracellularCl-couldactasasignalregulatingNa+reabsorptionthroughchangesin-subunitoftheENaC(-ENaC)mRNAexpressioninrenalepithelialA6cellsviaactivationofapathwaydependentonproteintyrosinekinases.Thisresultindicatesthatachangeof[Cl-]iisoneoftheimportantintracellularsignalsforregulationofcellularfunction....
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第5期LossofExpressionofTypeIVCollagenandChainsinColorectalCancerAssociatedwiththeHypermethylationofTheirPromoterRegion
...alcancer,manytypesofgenearesilencedbythehypermethylationoftheirpromoters.21Burbeloandcolleagues22demonstratedthattheexpressionofthe1(IV)/2(IV)chainswasinhibitedbythehypermethylationoftheirpromotersinteratocarcinomacells.However,therearenoreports,toourknowledge,thathaveinvestigatedtheregulatoryrelati...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第3期Completereversalofacid-inducedacutelunginjurybyblockingofplatelet-neutrophilaggregation
...evisedformSeptember19,2006.AbstractAcutelunginjury(ALI)causeshighmortality,butitsmolecularmechanismsarepoorlyunderstood.AcidaspirationisafrequentcauseofALI,leadingtoneutrophilsequestration,increasedpermeability,anddeteriorationofgasexchange.Weinvestigatedtheroleofplatelet-neutrophilinteractionsinamu...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第12期StichodactylahelianthusPeptide,aPharmacologicalToolforStudyingKv3.2Channels
...onChannels,MerckResearchLaboratories,Rahway,NewJersey(L.Y.,J.H.,P.M.D.,R.M.Bu.,R.S.S.,P.B.,R.M.Br.,B.T.P.,G.J.K.,M.L.G.)DepartmentofPhysiologyandNeuroscience,NewYorkUniversitySchoolofMedicine,NewYork,NewYork(E.G.,B.R.)AbstractVoltage-gatedpotassium(Kv)channelsregulatemanyphysiologicalfunctionsandrep...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第5期TheRoleofProteinSynthesisandDegradationinthePost-TranscriptionalRegulationofRatMultidrugResistance-AssociatedProtein2(Mrp2,Abcc2)
...ic-labelingstudieswith[35S]cysteine/methionineor[14C]NaHCO3,polysomaldistributionanalysesandribonucleaseprotectionassays(RPA).Mrp2proteinwassignificantlyincreasedinratstreatedwithPCNfor2daysbutsignificantlydecreasedin19-daypregnantratsrelativetocontrols;nosignificantdifferenceswereobservedinMrp2mRNA...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第3期Cocoapolyphenolsandinflammatorymediators
...sinplasmaweremeasured,anditwasshownthatingestionofthehigh-flavanolcocadrinkbutnotthelow-flavanolcocoadrinksignificantlyincreasedplasmaconcentrationsofnitrosocompoundsandflow-mediateddilationofthebrachialartery.Therefore,ingestedflavonoidsmayreverseendothelialdysfunctionthroughenhancementofNObioactiv...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第1期RoleofApoptosisSignal-RegulatingKinaseinStress-InducedNeuralCellApoptosisinVivo
...njury.ASK1wasexpressedinretinalneurons,includingretinalganglioncells(RGCs),butretinalstructureandextentofcelldeathduringdevelopmentwerenormalinASK1KOmice.Ontheotherhand,thestrainwaslesssusceptibletoischemicinjury,andthenumberofsurvivingretinalneuronswassignificantlyincreasedcomparedwiththatinwild-ty...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第1期OverexpressionduringChronicInjuryandInductionofProinflammatoryActionsinHepaticStellateCells
...ibrosisduringchronicliverdisease.Resistinantagonizesinsulinactioninrodents,butitsroleinhumansisstillcontroversial.Theaimsofthisstudyweretoinvestigateresistinexpressioninhumanliverandtoevaluatewhetherresistinmayaffectthebiologyofactivatedhumanhepaticstellatecells(HSCs),keymodulatorsofhepaticfibrogene...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期AntidiabetesandAntiobesityEffectofCryptotanshinoneviaActivationofAMP-ActivatedProteinKinase
...ers.Thus,theidentificationofacompoundthatactivatestheAMPKpathwaywouldcontributesignificantlytothetreatmentandmanagementofsuchsyndromes.Inserviceofthisgoal,wehavescreenedavarietyofnaturallyoccurringcompoundsandhaveidentifiedonecompound,cryptotanshinone,asanovelAMPKpathwayactivator.Cryptotanshinonewas...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第7期