Lowerplasma-carboxyethyl-hydroxychromanafterdeuterium-labeled-tocopherolsupplementationsuggestsdecreasedvitaminEmetabolisminsmokers
...eUniversity,Corvallis,OR(RSB,SWL,TMB,andMGT),andRoswellParkCancerInstitute,Buffalo,NY(JL)2SupportedbyagranttoMGT(NIHDK59576)andbytheEnvironmentalHealthSciencesCenteratOregonStateUniversity(NIEHSP30ES00210).TheNaturalSourceVitaminEAssociationprovidedthedeuterium-labeled-tocopherolsusedinthisinvestiga...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第5期InVivoActivationofHumanPregnaneXReceptorTightenstheBlood-BrainBarriertoMethadonethroughP-GlycoproteinUp-Regulation
...exposedtocertainP-glycoproteinsubstrates(Frommetal.,1997;Lotschetal.,2002),butthemechanismunderlyingtheincreaseintransporteractivityhasnotbeenidentified.Werecentlydetectedexpressionoftheligand-activated,pregnaneXreceptor(PXR)inisolatedratbraincapillaries(Baueretal.,2004).Previousstudiesinliverandgut...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期Cardiacmastcell-derivedreninpromoteslocalangiotensinformation,norepinephrinerelease,andarrhythmiasinischemia/reperfusion
...formingenzyme,e.g.,cathepsinD,aproteasethatcanconvertangiotensinogentoAngI,butatarate105timesslowerthanrenin(22),andthatis200timeslesssensitivethanrenintoBILA2157(21).Toverifythemastcell–degranulatingactionofcompound48/80,wealsoassayedhistamineoverflowintheguineapighearts.AsshowninFigure1A,coronar...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第4期AnapicalK+-dependentHCO3-transportpathwayopposestransepithelialHCO3-absorptioninratmedullarythickascendinglimb
...hange,Na+-dependentCl-/HCO3-exchange,orNa+-HCO3-cotransport.Incontrast,intubulesstudiedinNa+-andCl--freesolutionscontaining25mMHCO3-,5%CO2and120mMK+,removalofluminalK+inducedarapidandpronounceddecreaseinpHi(pHi=0.56±0.06pHU).pHirecoveredfollowinglumenK+readdition.Theinitialrateofnetbaseefflux...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第7期PemphigusIgGCausesSkinSplittinginthePresenceofBothDesmogleinandDesmoglein
...allossofDsg1.Weprovideevidencethatbothpemphigusfoliaceus-IgGcontainingDsg1-butnotDsg3-specificantibodiesandpemphigusvulgaris-IgGwithantibodiestoDsg1andDsg3wereequallyeffectiveincausingepidermalsplittinginhumanskinandkeratinocytedissociationinvitro.Theseeffectswerepresentwherekeratinocytesexpressedbo...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第9期DifferentialSensitivityofMouseEpithelialTissuestothePolyomavirusMiddleTOncogene
...ctedintoFVB/Nstrainmousezygotesasdescribedpreviously13,14byDr.LingWangoftheBurnhamInstituteMouseGeneticsLaboratorySharedResource.TransgenicmicewereidentifiedbyPCRoftaillysateDNA.MMTV-Cre7mice15wereprovidedbyDr.WilliamMuller(McGillUniversity,Montreal,Canada).PB-Cre4mice16wereprovidedbyDr.Roy-Burmanth...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第1期SustainedrenalinterstitialmacrophageinfiltrationfollowingchronicangiotensinIIinfusions
....WhenANGIIinfusionisdiscontinued,arterialpressuredecreasesbacktowardnormal,buttheratsdevelopasaltsensitivity,suchthathypertensionisreestablishedinresponsetoahigh-saltdiet(13,18,31,44).ThissaltsensitivityindicatesthatsomeofthechangesthatoccurduringthechronicANGIIinfusionperiodaresustainedandcontribut...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期XBP-1specificallypromotesIgMsynthesisandsecretion,butisdispensablefordegradationofglycoproteinsinprimaryBcells
...esX-boxbindingprotein–1(XBP-1).IntheabsenceofXBP-1,Bcellsdevelopnormally,butverylittleimmunoglobulinissecreted.XBP-1controlstheexpressionofalargesetofgeneswhoseproductsparticipateinexpansionoftheendoplasmicreticulum(ER)andinproteintrafficking.WedefineanewroleforXBP-1inexertingselectivetranslationa...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第4期DistinctiveExpressionofChemokinesandTransformingGrowthFactor-ßSignalinginHumanArterialEndotheliumduringAtherosclerosis
...de,inbredmousemodelsofacceleratedatherosclerosishavealsosignificantlycontributedtothelargebodyofpathophysiologicalknowledgeonthedevelopmentofatherosclerosis.12Inadditiontothesemousestudiesandsingle-geneapproaches,anumberofrecentstudieshaveassessedtheroleoftranscriptomechangesinthedevelopmentofhumana...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第7期Sazetidine-A,ANovelLigandThatDesensitizes4β2NicotinicAcetylcholineReceptorswithoutActivatingThem
...tandingofthesereceptors(Brejcetal.,2001;Unwin,2005).Theyarecomposedoffivesubunitsassembledaroundacentralionchannel.Alargeextracellulardomain,composedofN-terminalportionsofallfivesubunits,containstwotofiveligandbindingsitesformedbetweenansubunitandanadjacentsubunit.Eachsubunithasfourtransmembrane-hel...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期