Endomucin,aCD34-likesialomucin,markshematopoieticstemcellsthroughoutdevelopment
...c-Kit+Sca-1+Lin–(CD34–KSL)HSCs.Oneoftheidentifiedmolecules,Endomucin,isanendothelialsialomucincloselyrelatedtoCD34.High-levelexpressionofEndomucinwasconfinedtotheBMKSLHSCsandprogenitorcells,and,importantly,long-termrepopulating(LTR)–HSCswereexclusivelypresentintheEndomucin+CD34–KSLpopulation...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第11期Aroleforfungal-glucansandtheirreceptorDectin-1intheinductionofautoimmunearthritisingeneticallysusceptiblemice
...ycleancondition,despiteactivethymicproductionofarthritogenicautoimmuneTcellsandtheirpersistenceintheperiphery.However,inthecleanenvironment,asingleintraperitonealinjectionofzymosan,acrudefungal-glucan,orpurified-glucanssuchascurdlanandlaminarincantriggerseverechronicarthritisinSKGmice,butonlytransie...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第6期RGS2IsaMediatorofNitricOxideActiononBloodPressureandVasoconstrictorSignaling
...teinforGqthatiscriticalforbloodpressurehomeostasis,hasbeensuggestedtoserveasaneffectoroftheNO-cGMPpathwaythatpromotesvascularrelaxationbasedonstudiesofaorticringsinvitro.Totestthishypothesisanditsrelevancetobloodpressurecontrol,wedeterminedwhetherRGS2functionsasanNOeffectorinsmoothmuscleoftheresista...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第3期ComparativeSequencingoftheSerine-AspartateRepeat-EncodingRegionoftheClumpingFactorBGene(clfB)forResolutionwithinClonalGroupsofStaphylococc
...arrayanalyses.Thislimitationhindersstraininterrogationfornewlyemergingclonesandoutbreakinvestigationsinhospitalorcommunitysettingswhererobustclonesareendemic.Toovercomethisconstraint,wedevelopedatypingsystemusingDNAsequenceanalysisoftheserine-aspartate(SD)repeat-encodingregionwithinthegeneencodingth...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期SystematicMolecularCharacterizationofMultidrug-ResistantMycobacteriumtuberculosisComplexIsolatesfromSpain
...thestudyperiodwasextendedto3years(13).Multidrug-resistant(MDR)TBisemergingasanincreasinglymajorcauseofmorbidityandmortality(22).MDRTBoutbreakshavebeendescribedworldwide(1,2,20,24,27).HighlyresistantstrainsofTBhavecausednumerousinstitutionaloutbreaks(hospitals,prisons,andshelters),withhighcase-fatali...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第3期Antioxidantsprotectfromatherosclerosisbyahemeoxygenase-1pathwaythatisindependentoffreeradicalscavenging
...es.Astrikingexceptionisprobucol,whichretardsatherosclerosisincarotidarteriesandrestenosisofcoronaryarteriesafterangioplasty.Becauseprobucolhasinvitrocellular-protectiveeffectsindependentofinhibitinglipidoxidation,weinvestigatedthemodeofactionofprobucolinvivo.Weusedthreemodelsofvasculardisease:apolip...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期ModulatingtheFoldingofP-GlycoproteinandCysticFibrosisTransmembraneConductanceRegulatorTruncationMutantswithPharmacologicalChaperones
...ngoftruncationmutantslackingoneorbothNBDs.Sensitivitytoglycosidaseswasusedasanindirectindicatoroffolding.ItwasfoundthatVRT-325couldpromotematurationoftruncationmutantslackingNBD2.TruncationmutantsofCFTRorP-gplackingbothNBDsshoweddeficienciesincore-glycosylationthatcouldbepartiallyreversedbycarryingo...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期MicroRNAsinTumorigenesis
...tmiRNAresearchwillprovidebreakthroughsintheunderstandingofcancerpathogenesisanddevelopmentofnewvaluableprognosticmarkers,pathologistsshouldbeadequatelyinformedofthisrapidlyprogressingfield.Here,weofferareviewonthebasicsofmiRNAbiologyandtheemergingroleofmiRNAincancerpathogenesis,classification,andpro...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第9期ANovelMultivalentLigandThatBridgestheAllostericandOrthostericBindingSitesoftheM2MuscarinicReceptor
...nonM2receptorstowhichthetypicalallostericmodulatorsgallamineandW84bind(EllisandSeidenberg,1992;TrankleandMohr,1997).BaseduponcomparisonwiththeX-raycrystalstructureofbovinerhodopsin,theAChbindingpocketofthemuscarinicM2receptorisbelievedtobelocatedinanarrowcavityformedbythesevenmembrane-spanningregion...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第8期PolyunsaturatedFattyAcidsInduce-Synuclein-RelatedPathogenicChangesinNeuronalCells
...dtobeprotective.WeconcludethatalterationsinPUFAlevelscanleadtoaggregationofSandsubsequentdepositionintopotentiallycyto-toxicoligomersthatprecedeinclusionsindopa-minergiccells.---------------------------------------------------------------------------------Synuclein(S)isapresynapticproteinimplicatedi...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第12期