葡萄球菌肠毒素C的纯化与标准参考品的制备研究
...养方式培养36~40h,可使除菌滤液中SEC达到较高量(33840ng/ml);用POST-FLO-Ⅱ型流动循环超滤泵,以10000dalton超滤膜超滤截留浓缩。使SEC原液浓缩约10倍(336800ng/ml);再通过DEAE-纤维素柱层析使SEC纯度达到46.1%。最后通过SephadexG-75...
医源资料库;在线期刊;中华医药杂志;2007年第7卷第5期ThechemokineKCregulatesHGF-stimulatedepithelialcellmorphogenesis
...要】Hepatocytegrowthfactor(HGF)inducesmigration,proliferation,andbranchinginrenalepithelialcellsfromtheinnermedullarycollectingduct(mIMCD-3cells).MicroarrayanalysisafterHGFstimulationofthesecellsrevealedupregulationofthechemokineKC.WefoundthatboththemessageandproteinlevelsofKCareincreasedafterHGFt...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第3期人血浆中奥美拉唑高效液相色谱测定法及其药代动力学研究
...收率为87.02%~98.07%,血浆中奥美拉唑的最低检出浓度为3ng.mL-1,线性范围为5~1800ng.mL-1。用本法测定了12名志愿者随机交叉口服单剂量40mg洛赛克胶囊和奥美拉唑肠溶片后血浆中奥美拉唑的浓度经时变化过程,并对其药动学参数进...
药品天地;专业药学;实验技术;色谱技术;色谱论文M1与7TD1细胞中IL-6激活核因子的比较
...活是一过性的;而IL-6在7TD1细胞中激活NF-IL6所需的剂量(0.1ng/ml)远低于在M1细胞中所需的剂量(100.0ng/ml),不过活化的NF-IL6在两种细胞中持续的时间均超过60min。结论:JAK-STATs通路与P21ras/MAPK/NF-IL6通路可能分别代表生长抑制信号与生...
合作平台;医学论文;临床医学与专科论文;检验医学TGF-impairsrenalautoregulationviagenerationofROS
...ularcapillarypressureandprogressiveglomerulardamage;however,thefactorslinkingchronicglomerulardisorderstoimpairedautoregulationhavenotbeenidentified.Wetestedthehypothesisthatthecytokinemostcloselyassociatedwithprogressiveglomerulardisease,transforminggrowthfactor(TGF)-,mayalsoattenuateautoregulation...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第5期皮质激素水平和全身性皮质激素在稳定期慢性阻塞性肺疾病中的应用
...但治疗组未发现有明显的改善,由于公认的激素副作用,因而指南不推荐在稳定期病人长期应用激素。但是在临床实践中我们注意到,部分稳定期病人主动口服激素或者含激素药物,表明激素的客观疗效确切,只是在激素应用的...
医源资料库;在线期刊;中华现代内科学杂志;2007年第4卷第5期肝硬化伴自发性细菌性腹膜炎患者血清和腹水IL-6及TNF-a的临床意义
...腹水病人血清及腹水IL-6和TNF-α检测结果组别例数TNF-α(ng/L)IL-6(ng/L)血腹水血腹水SBP组23377.63±81.54535.47±111.23△228.59±78.411499.32±462.11△无SBP组21144.67±18.81*130.39±30.45*123.56±32.71*593.57±32.45*△ *两组比较,t值分别为2.63和3.23,...
合作平台;医学论文;临床医学与专科论文;检验医学RaisedPlasmaSolubleP-SelectininPeripheralArterialOcclusiveDiseaseEnhancesLeukocyteAdhesion
...clear.InthisstudywehaveexaminedapotentialroleforplasmasP-selectininregulatingneutrophiladhesioninpatientswithperipheralarterialocclusivedisease(PAOD).PatientswithPAODhadsignificantlyhigherlevelsofsP-selectin(mean±SD:73.3±13.0versus16.7±6.4ng/mL)andenhancedwholebloodleukocyteadhesiontoplateletsund...
医源资料库;在线期刊;循环研究杂志;2006年第96卷第1期TGF-1-inducedEMTcanoccurindependentlyofitsproapoptoticeffectsandisaidedbyEGFreceptoractivation
...ccurinstressedtubularepithelialcellsandcontributetorenalfibrosis.Transforminggrowthfactor(TGF)-1promotestheseresponsesandweexaminedwhethertheprocesseswereinterdependentinvitro.Direct(caspaseinhibition)andindirect[epidermalgrowthfactor(EGF)receptorstimulation]strategieswereusedtoblockapoptosisduringT...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期pNeurotrophinReceptor-MediatedSignalingPromotesHumanHairFollicleRegression(Catagen)
【摘要】Nervegrowthfactor(NGF)anditsapoptosis-promotinglow-affinityreceptor(p75NTR)regulatemurinehaircycling.However,itisunknownwhetherhumanhairgrowthisalsocontrolledthroughp75NTR,itshigh-affinityligandpro-NGF,and/orthegrowth-promotinghigh-affinityNGFreceptortyrosinekinaseA(TrkA).Inmicrodissecte...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第1期