PAR1,butNotPAR4,ActivatesHumanPlateletsthroughaGi/o/Phosphoinositide-3KinaseSignalingAxis
...wthatPAR1couplestoGi/oinhumanplateletsandactivatesphosphoinositide-3kinase(PI3K).PI3KactivationregulatesplateletintegrinIIb3activationandplateletaggregationandpotentiatesthePAR1-mediatedincreaseinintraplateletcalciumconcentration.PI3KinhibitorseliminatedtheseeffectsdownstreamofPAR1,buttheyhadnoeffec...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第5期PredictorsofHIVDrug-ResistanceMutationsinaLargeAntiretroviral-NaiveCohortInitiatingTripleAntiretroviralTherapy
...ishColumbia,Canada.Methods.Allplasmasampleswithplasmavirusloads(pVLs)1000copies/mLcollectedduringthefirst30monthsoffollow-upweregenotypedfordrugresistance.Theprimaryoutcomemeasurewastimetothefirstdetectionofmajordrug-resistancemutation(s).Coxproportionalhazardregressionwasusedtoidentifyfactorssignif...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第3期蛋白质组鉴定技术
...Phospho或Fluoroimagers,对图象进行数字化.并成为以象素(pixels)为基础的空间和网格.其次,在图象灰度水平上过滤和变形,进行图象加工,以进行斑点检测.利用Laplacian,Gaussian,DOG(differenceofGaussians)opreator使有意义的区域与背景分...
行业资讯;临床快报;细胞分子与蛋白质组蛋白质组鉴定技术
...Phospho或Fluoroimagers,对图象进行数字化.并成为以象素(pixels)为基础的空间和网格.其次,在图象灰度水平上过滤和变形,进行图象加工,以进行斑点检测.利用Laplacian,Gaussian,DOG(differenceofGaussians)opreator使有意义的区域与背景分...
医药经济;生物技术;实验技术;生化与分子技术蛋白质组鉴定技术
...Phospho或Fluoroimagers,对图象进行数字化.并成为以象素(pixels)为基础的空间和网格.其次,在图象灰度水平上过滤和变形,进行图象加工,以进行斑点检测.利用Laplacian,Gaussian,DOG(differenceofGaussians)opreator使有意义的区域与背景分...
药品天地;专业药学;实验技术;色谱技术;色谱入门Acidosisimpairsinsulinreceptorsubstrate-1-associatedphosphoinositide3-kinasesignalinginmusclecells:consequencesonproteolysis
...atesproteolysisbyinhibitinginsulinsignalingthroughphosphoinositide3-kinase(PI3K).InculturedL6myotubes,acidified(pH7.1)mediadidnotacceleratethebasalproteindegradationrate,butitinhibitedinsulinsabilitytosuppressproteolysis.Insulinreceptorsubstrate-1(IRS-1)-associatedPI3Kactivitywasnotalteredincellsaci...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第10期CilostazolProtectsAgainstBrainWhiteMatterDamageandCognitiveImpairmentinaRatModelofChronicCerebralHypoperfusion
...dimmunohistochemistryfor4-hydroxy-2-nonenal(HNE),glutathione-S-transferase-pi(GST-pi),ionizedcalcium-bindingadaptormolecule1,phosphorylatedCREB(p-CREB),Bcl-2,andcyclooxygenase-2(COX-2)wereanalyzedatbaselineandat3,7,14,21,and28daysafterhypoperfusion.Result—Cilostazolsignificantlyimprovedspatiallear...
医源资料库;在线期刊;中风学杂志;2006年第37卷第6期CorrelationbetweenhyperphosphatemiaandtypeIINa-Picotransporteractivityinklothomice
...phatehomeostasis.ThegoalofthepresentstudywastoinvestigatetheregulationofNa-Picotransportersinklothomutant(kl/kl)mice.Thekl/klmicedisplayedhyperphosphatemia,highplasma1,25(OH)2D3levels,increasedactivityoftherenalandintestinalsodium-dependentPicotransporters,andincreasedlevelsofthetypeIIa,typeIIb,andt...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期Caveolin-1FacilitatesMechanosensitiveProteinKinaseB(Akt)SignalingInVitroandInVivo
...iously,wedemonstratedamechanosensitiveactivationofphosphoinositide3-kinase(PI3-K)/proteinkinaseB(Akt)resultinginp27Kip1transcriptionaldownregulationandcellcycleentryofvascularsmoothmusclecells(VSMC).Inthisstudy,wefurtherelucidatedthesignalingfromoutside-intowardPI3-K/Aktinvitroandinaninvivomodelofel...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第4期HIV-1ProteaseandReverse-TranscriptaseMutations:CorrelationswithAntiretroviralTherapyinSubtypeBIsolatesandImplicationsforDrug-ResistanceSurvei
...1sequencesfrompersonswithandwithoutprevioustreatmentwithproteaseinhibitors(PIs),nucleosideRTinhibitors(NRTIs),andnonnucleosideRTinhibitors(NNRTIs).Treatment-associatedmutationsinproteaseisolatesfrom5867personsandRTisolatesfrom6247personswerecategorizedbywhethertheywerepolymorphic(prevalence,0.5%)inu...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第15期