AnessentialroleforSKAP-55inLFA-1clusteringonTcellsthatcannotbesubstitutedbySKAP-55R
...vebeenimplicatedinLFA-1clustering(12–18).TransgenicmiceoverexpressingRap1showenhancedLFA-1binding(19),whereasadominantnegativeformofRapLinhibitsclusteringandconjugation(20).Furthermore,theretroviralexpressionofSKAP-55enhancesLFA-1clusteringandadhesion(17),whereasadap–/–TcellsshowdefectsinLFA-1...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第11期高效液相色谱法测定调肝灵片中大黄素和大黄酚的含量
【摘要】目的建立以高效液相色谱法测定调肝灵片中大黄素、大黄酚含量的方法。方法色谱柱:以十八烷基硅烷键合硅胶为填充剂,流动相:甲醇-0.1%磷酸溶液(85:15)为流动相;流速:1.0ml/min;检测波长:254nm;柱温:30℃,进...
药品天地;专业药学;实验技术;色谱技术;色谱论文马俊凤,李红兵,王友兰:高效液相色谱法测定保肾合剂中大黄素含量
...市药品检验所,山东青岛266071)保肾合剂由黄芪、党参、大黄、白术、甘草、丹参等16味中药组成,具有补肾益气、活血化瘀、祛毒保肾等作用,主要用于化疗期间保护肾脏功能,提高机体免疫力。该合剂为青岛肿瘤医院自制制剂...
药品天地;专业药学;药学研究NeuropeptideFF(NPFF)AnalogsFunctionallyAntagonizeOpioidActivitiesinNPFF2Receptor-TransfectedSH-SY5YNeuroblastomaCells
...mofthecellularantiopioidactivityofneuropeptideFF(NPFF),wehavetransfectedtheSH-SY5Yneuroblastomacellline,whichexpressese?and-opioidreceptors,withthehumanNPFF2receptor.Theselectedclone,SH2-D9,expressedhigh-affinityNPFF2receptorsinthesamerangeorderase?and-opioidreceptors(100eC300fmol/mgofprotein).TheNP...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第3期Interferon-InducesFasTraffickingandSensitizationtoApoptosisinVascularSmoothMuscleCellsviaaPIK-andAkt-DependentMechanism
...tosiscancontributetoruptureofmouseplaquesinassociationwithotherstimulisuchashemodynamicstress.6Multipletriggersofapoptosisexistinthecomplexmicroenvironmentoftheplaque,andtheinductionofapoptosisreflectsthebalancebetweendiversepro-andanti-apoptoticsignaling.7However,increasingevidenceimplicatesthetumo...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第6期Dlgh1coordinatesactinpolymerization,synapticTcellreceptorandlipidraftaggregation,andeffectorfunctioninTcells
...e-associatedguanylatekinase(MAGUK)familymolecularscaffoldsfunctioninestablishingcellpolarityandorganizingsignaltransducerswithinepithelialcelljunctionsandneuronalsynapses.Here,weelucidatearolefortheMAGUKprotein,Dlgh1,inpolarizedTcellsynapseassemblyandTcellfunction.WefindthatDlgh1translocatestotheimm...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期PlasmavitaminB-6formsandtheirrelationtotranssulfurationmetabolitesinalarge,population-basedstudy
ØivindMidttun,SteinarHustad,JørnSchneede,SteinEVollsetandPerMUeland1FromBevitalA/S,ArmauerHansensHus,Bergen,Norway(ØMandPMU);LOCUSforHomocysteineandRelatedVitamins,UniversityofBergen,Bergen,Norway(ØM,SH,JS,SEV,andPMU);theHormoneLaboratory,HaukelandUniversityHospital,Berge...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第1期正交试验法优选妇舒片的提取工艺
...片的最佳提取工艺。方法采用正交试验法,以浸膏得率、大黄素和大黄酚含量为考察指标,对影响提取工艺的因素进行了研究。结果最佳提取工艺:药材提取2次,加12倍量的水,提取时间2h。结论该提取工艺方法可行、工艺稳定...
医源资料库;在线期刊;中华现代中医学杂志;2005年第1卷第1期PilotStudyToEvaluateMicroarrayHybridizationasaToolforSalmonellaentericaSerovarTyphimuriumStrainDifferentiation
...imple83-probeDNAmicroarray.ThedatapresentedheredemonstratethatDNAmicroarraysharboringsmallnumbersofselectedprobesarepromisingtoolsforserovarTyphimuriumstraintyping.INTRODUCTIONSalmonellaspp.arepathogenicenterobacteriawhichcancausefood-bornediseasesrangingfromamildgastroenteritistosystemicinfections(...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期EvidenceforicaADBC-IndependentBiofilmDevelopmentMechanisminMethicillin-ResistantStaphylococcusaureusClinicalIsolates
...firmthepresenceoftheica::tetalleleonthechromosomeofcandidatemutants(datanotshown).Interestingly,ananalysisofBH1CCandanisogenicica::tetmutantgrowninBHI,BHI-NaCl,andBHI-glucoserevealednosubstantialdifferencesinbiofilm-formingcapacity(Fig.2A).Thesedataareconsistentwithourearlierfindingsthaticaoperonexp...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第4期