Cyclooxygenases,microsomalprostaglandinEsynthase-1,andcardiovascularfunction
...P0.001)inWTmice.However,deletionofmPGES-1depressedPGEMinbothsexes.Interestingly,asimilarsexdifferenceinTXM(335.7±43.4ng/mgcreatinineinmalesversus706.3±86.7ng/mgcreatinineinfemales,n=12–20pergroup;P0.05),butnotinPGIM(6.2±1.0ng/mgcreatinineinmalesversus5.5±1.1ng/mgcreatinineinfemales,n=8–12per...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期RepressionofHumanGSTA1byInterleukin-1IsMediatedbyVariantHepaticNuclearFactor-1C
...luciferaseplasmid),andincreasingconcentrationsofthepHNF-1weretransfectedusingLipofectamine(Invitrogen)accordingtothemanufacturer‘srecommendations.After24h,mediumcontaining10ng/mlIL-1wasadded.Twenty-fourhourslater,cellswereharvestedandwashedtwicewithphosphate-bufferedsaline,cellextractswereprepared...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期Adhesivemechanismsgoverninginterferon-producingcellrecruitmentintolymphnodes
...hmentofTcells.Typically,this2-integrinexistsinaninactivatedstateoncirculatinglymphocytes.ItsabilitytointeractwithICAMsreliesonGi-linkedintracellularsignalingeventsthatresultfromtheengagementofchemokinereceptorssuchasCCR7(19)withitscognateligandsCCL21(20,21)and,possibly,CCL19(22,23).Thisresultsinalte...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第5期ExpressionofP2XandP2Yreceptorsintheintramuralparasympatheticgangliaofthecaturinarybladder
...onofP2XandP2Yreceptorsubtypeswereinvestigatedonintactorculturedintramuralgangliaofthecaturinarybladderbyimmunocytochemistryandcalcium-imagingtechniques,respectively.NeuronswerelabeledbyallsevenP2XreceptorsubtypeantibodiesandantibodiesforP2Y2,P2Y4,P2Y6,andP2Y12receptorsubtypeswithastainingintensityof...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期新型阿片类药物在病人自控镇痛中应用研究的进展
...lebranddisease.RevEspAnesthesiolReanim.2003,50(5):242-244.4.Dill-RussellPC,NgL,RavaliaA.Useofaremifentanilforapatientwithmultipleribfractures.CanJAnaesth.2002,49(7):757.5.林传尧,岳云,柳娟.舒芬太尼病人自控静脉镇痛的观察.临床麻醉学杂志,2004,20(1):51-52.6.许立新,佘守...
合作平台;医学论文;外科论文;麻醉学新型阿片类药物在病人自控镇痛中应用研究的进展
...lebranddisease.RevEspAnesthesiolReanim.2003,50(5):242-244.4.Dill-RussellPC,NgL,RavaliaA.Useofaremifentanilforapatientwithmultipleribfractures.CanJAnaesth.2002,49(7):757.5.林传尧,岳云,柳娟.舒芬太尼病人自控静脉镇痛的观察.临床麻醉学杂志,2004,20(1):51-52.6.许立新,佘守...
合作平台;医学论文;外科论文;麻醉学Insulinresistanceandatherosclerosis
...fcellularhomeostasiscausedbytheexcessdeliveryoffuel.Insulinresistanceisstronglyassociatedwithatherosclerosisandfrequentlycoexistswithcommonproatherogenicdisorders;thisrelationshipisnotnew.Untilthe1700s,diseasewasthoughttobecausedby“humors,“aconceptdatingfromthetimeofHippocrates.Theyear1761wasnot...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第7期Deiodinases:implicationsofthelocalcontrolofthyroidhormoneaction
...yroidhormone,andtheirimportanceinthyroidhormonehomeostasishasbecomeincreasinglyclearwiththeavailabilityofdeiodinase-deficientanimals.Atthesametime,heightenedinterestinthefieldhasbeengeneratedfollowingthediscoverythatthetype2deiodinasecanbeanimportantcomponentinboththeHedgehogsignalingpathwayandtheGp...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期IsoprenoidsdetermineTh1/Th2fateinpathogenicTcells,providingamechanismofmodulationofautoimmunitybyatorvastatin
...strationofsimvastatin(Zocor)reducedtheexpectednumberofnewgadolinium-enhancinglesionsinrelapsing-remittingmultiplesclerosis(MS)patientsby44%inasmall6-moopen-labeltrial(1).Therelateddrugatorvastatin(AT)(Lipitor)hasalsoshownpromisingresultsinloweringdiseasescoresandvascularriskfactorsinpatientswithrheu...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第2期Mechanismsofprogressionandregressionofrenallesionsofchronicnephropathiesanddiabetes
...chadaptivechangeslimitGFRdeclineandstructuraldamage(14).Apossiblelinkbetweenglomerularhypertensionandproteinuriawasnotestablishedformallyatthattime;nevertheless,Cameronhadalreadyfoundthatpatientswithnephroticsyndromedidprogressmorerapidlythanthosewhohadneverbeennephrotic(15,16).Thiswasinharmonywithp...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第2期