Q-T间期延长的观察与治疗
...时,被认为Q-T间期延长,长Q-T间期的患者易发生晕厥或阿-斯综合征,发生猝死的报道亦非常罕见,所以加强对Q-T间期延长患者的观察对治疗至关重要。1Q-T间期的计算Q-T间期代表心室肌除极、复极两过程的总时间,任何影响除极和复极...
医源资料库;在线期刊;中华现代临床医学杂志;2006年第4卷第23期牛磺酸对大鼠庆大霉素中毒性急性肾损伤的保护作用
...随机分为3组,牛磺酸组(n=12):腹腔注射庆大霉素100mg/kg,每天1次,共7d,于每次注射前6h腹腔注射100g/L牛磺酸7.5mL/kg;庆大霉素组(n=12):同法注射庆大霉素,腹腔注射生理盐水代替牛磺酸;对照组(n=12):用等量生理盐水...
医源资料库;在线期刊;齐鲁医学杂志;2007年第22卷第5期RoscovitineTriggersExcitotoxicityinCulturedGranuleNeuronsbyEnhancingGlutamateRelease
DepartmentofNeuroscienceandPhysiology,StateUniversityofNewYork,UpstateMedicalUniversity,Syracuse,NewYorkAbstractCerebellargranuleneuronsarehighlysusceptibletoinjuryinvivoandinvitro,andprimaryculturesarewidelyusedtocharacterizerelevantreceptorsandsignalingpathways.However,thereareproblemsassociatedwi...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期cIAP2isaubiquitinproteinligaseforBCL10andisdysregulatedinmucosa-associatedlymphoidtissuelymphomas
1AbramsonFamilyCancerResearchInstituteandDepartmentofCancerBiology,UniversityofPennsylvaniaSchoolofMedicine,Philadelphia,Pennsylvania,USA.2DepartmentofPathology,DivisionofMolecularHistopathology,UniversityofCambridge,Cambridge,UnitedKingdom.3DepartmentofBiologyandProteinNetworkResearchCenter,YonseiU...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第1期Whole-grainconsumptionisassociatedwithareducedriskofnoncardiovascular,noncancerdeathattributedtoinflammatorydiseasesintheIowaWomen‘sHealth
...ciences,UniversityofOslo,Oslo,Norway(DRJ,LFA,andRB);theDivisionofEpidemiologyandCommunityHealth,SchoolofPublicHealth,UniversityofMinnesota,Minneapolis,MN(DRJ)2Thecontentsofthismanuscriptaresolelytheresponsibilitiesoftheauthorsanddonotnecessarilyrepresenttheofficialviewofthefundingbodies.3RBwassuppor...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第6期GeneticPathwaystoPrimaryandSecondaryGlioblastoma
【摘要】90%)areprimaryglioblastomasthatdeveloprapidlydenovo,withoutclinicalorhistologicalevidenceofalessmalignantprecursorlesion.Theyaffectmainlytheelderlyandaregeneticallycharacterizedbylossofheterozygosity10q(70%ofcases),EGFRamplification(36%),p16INK4adeletion(31%),andPTENmutations(25%).Second...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期FunctionalValidationoftheGeneticPolymorphismsofHumanATP-BindingCassette(ABC)TransporterABCG2:IdentificationofAllelesThatAreDefectiveinPorp
【关键词】FunctionalValidationTheATP-bindingcassette(ABC)transporterABCG2hasbeenimplicatedtoplayasignificantroleintheresponseofpatientstomedicationand/ortheriskofdiseases.ToclarifythepossiblephysiologicalorpathologicalrelevanceofABCG2polymorphisms,wehavefunctionallyvalidatedsinglenucleotidepoly...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期MolecularEvolutionofHumanInfluenzaA/H3N2VirusinAsiaandEuropefrom2001to2003
AppliedImmunologyandMicrobiologyDivision,WyethVaccinesResearch,PearlRiver,NewYork10965ABSTRACTHemagglutininsequencesof146humaninfluenzaA/H3N2strainsidentifiedinrespiratoryspecimensfromAsiaandEuropeduringthe2001-2003influenzaseasonswereanalyzedbyDNAsequencing.Ourresultssuggestthatfouraminoacidsubstit...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期Tyr702IsanImportantDeterminantofAgonistBindingandDomainClosureoftheLigand-BindingCoreofGluR2
...tructuralResearch,DepartmentofMedicinalChemistry(A.F.,B.V.,C.K.,B.B.N.,J.R.G.,M.G.,J.S.K.)andDepartmentofPharmacology(D.S.P.,A.S.),DanishUniversityofPharmaceuticalSciences,Copenhagen,DenmarkDipartimentoFarmacoChimicoTecnologicoandEuropeanResearchCentreforDrugDiscoveryandDevelopment,SienaUniversity,S...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第3期GlycosylationoftheosmoresponsivetransientreceptorpotentialchannelTRPV4onAsn-651influencesmembranetrafficking
【摘要】WeidentifiedaconsensusN-linkedglycosylationmotifwithinthepore-formingloopbetweenthefifthandsixthtransmembranesegmentsoftheosmoresponsivetransientreceptorpotential(TRP)channelTRPV4.MutationofthisresiduefromAsntoGln(i.e.,TRPV4N651Q)resultedinlossofaslowermigratingbandonanti-TRPV4immunoblot...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期