MastocytosisinmiceexpressinghumanKitreceptorwiththeactivatingAsp816Valmutation
...lear.Inaddition,theclinicalheterogeneitypresentedbymastocytosispatientscarryingthesamemutationisunexplained.WereportthatadiseasewithstrikingsimilaritiestohumanmastocytosisdevelopsspontaneouslyintransgenicmiceexpressingthehumanAsp816ValmutantKitprotooncogenespecificallyinMCs.Thisdiseaseischaracterize...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第12期早期护理干预对早产儿生长发育的影响
...时B组和C组婴儿奶量摄入、体重显著高于A组(P<0.05),睡眠时间增长,睡眠质量提高(P<0.05),且C组的增加幅度更大(P<0.01)。结论抚触护理有利于早产儿的生长发育,联合鸟巢式护理使早产儿生长激素的分泌达到最佳水平...
医源资料库;在线期刊;中华现代护理学杂志;2008年第5卷第9期Phosphorylation-dependenttranslocationofsphingosinekinasetotheplasmamembranedrivesitsoncogenicsignalling
...arsignal–regulatedkinase1/2–mediatedphosphorylationatSer225,whichnotonlyincreasescatalyticactivity,butisalsonecessaryforagonist-inducedtranslocationofhSK1totheplasmamembrane.Inthisstudy,wereportthattheoncogeniceffectsofoverexpressedhSK1areblockedbymutationofthephosphorylationsitedespitethephosph...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第1期食欲素与全身麻醉机制的关系
...举了食欲素的主要作用,包括调控摄食、饮水行为,参与睡眠觉醒周期、能量代谢,以及对自主神经系统的调节等,并根据目前关于食欲素与全身麻醉机制的相关研究结果,进行了深入讨论。【关键词】食欲素;食欲素受体;全...
医源资料库;在线期刊;中华现代外科学杂志;2009年第6卷第5期在高等数学教学中融入数学建模思想
...ofMathematicsModelingThoughtintheHigherMathematicsTeachingZHANGMing1,HUWen-yi2,WANGXia1(1.DepartmentofBasicsofComputerScience,ChengduMedicalCollege,Chengdu610083,China;2.ChengduUniversityofTechnology,Chengdu610059,China)Abstract:Thepurposeofstudyinghighermathematicsistosolvepracticalpr...
医源资料库;在线期刊;成都医学院学报;2007年第2卷第3期ADV治疗LAM-R慢性乙肝疗效观察
...当疗程≥1年后再次复阳并伴ALT≥2U/L;耐药基因检测证实YIDD和/或YVDD。1.2观察设计入选慢性乙肝患者90例,按照1:1:1比例,将患者分为A、B、C3组,分别为ADV+LAM、ADV与LAM治疗组,疗程1年,各组不服任何降酶护肝药。A组于1年后分为3...
医源资料库;在线期刊;中华中西医杂志;2006年第7卷第7期PlasmaB-TypeNatriureticPeptideLevelsAreAssociatedWithEarlyCardiacDysfunctionAfterSubarachnoidHemorrhage
...0ofSAHbycomputedtomographyorlumbarpuncture.Patientswereincludedinthesubstudyiftheyconsentedforstorageofplasmasamplesandexcludediftheyhadhistory(obtainedfromthepatient,family,ormedicalrecords)ofmyocardialinfarctionorcongestiveheartfailure.ThestudyprotocolwasapprovedbytheUCSFCommitteeonHumanResearchan...
医源资料库;在线期刊;中风学杂志;2005年第36卷第7期KnockyourSOCSoff!
...gicalprocessesbyactivatingcellsurfacereceptorcomplexes,aprocessthatinitiallyinvolvesoligomerizationandactivationoftheJAKfamilyoftyrosinekinases.Inturn,JAKsphosphorylatethecellsurfacereceptor,andsignalingproteinssuchasSTATsarerecruitedtothesephosphotyrosinesitesonthereceptor;theproximityoftheSTATsall...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第2期Enhancementofclonogenicityofhumanmultiplemyelomabydendriticcells
...dinteractions.Together,thesedatasuggestthattumor–DCinteractionsmaydirectlyimpactthebiologyofhumantumors,particularlymultiplemyeloma,andmaybeatargetfortherapeuticintervention.DCshavebeenstudiedextensivelyinthecontextofimmunitytotumors(forreviewsseereferences1,2).Severalstudieshavedocumentedtheincre...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期ComparativeEvaluationofThreeCommercialSystemsforNucleicAcidExtractionfromUrineSpecimens
...ingagoodsolutiontotheneedforsporadicbutemergentspecimendetection.TheminiMAGyieldedthehighestquantityofnucleicacids,suggestingthatthissystemwouldbethebestforspecimenscontainingalownumberofmicroorganismsofinterest.TEXTNucleicacidamplificationtechniquesarebeingincorporatedmoreandmoreintoclinicallaborat...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期