Neutrophilsfromp40phox–/–miceexhibitseveredefectsinNADPHoxidaseregulationandoxidant-dependentbacterialkilling
...oreofthisoxidaseconsistsofacomplexbetweengp91phox,p22phox,p47phox,p67phox,p40phox,andrac-2.Mutationsineachofthephoxcomponents,exceptp40phox,havebeendescribedincasesofchronicgranulomatousdisease(CGD),definingtheiressentialroleinoxidasefunction.Wesoughttoestablishtheroleofp40phoxbyinvestigatingtheNADP...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期CD4memoryTcellssurviveandproliferatebutfailtodifferentiateintheabsenceofCD40
...izationformorethan200days,althoughdecaywasapparent.MemorycellsgeneratedinCD40knockoutmicebyimmunizationwithpeptide-pulsedwild-typedendriticcellssurvivedintheabsenceofCD40andproliferatedwhenboostedwithpeptide(plusadjuvant)inaCD40-independentfashion.However,differentiationofthememorycellsintocytokine-...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期PreventionofArthritisbyInterleukin10–producingBCells
...shownthatactivationofarthritogenicsplenocyteswithantigenandagonisticanti-CD40givesraisetoaBcellpopulationthatproducehighlevelsofinterleukin(IL)-10andlowlevelsofinterferon(IFN)-.TransferoftheseBcellsintoDBA/1-TcR-ß-Tgmice,immunizedwithbovinecollagen(CII)emulsifiedincompleteFreund‘sadjuvantinh...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第3期PreventionofArthritisbyInterleukin10–producingBCells
...shownthatactivationofarthritogenicsplenocyteswithantigenandagonisticanti-CD40givesraisetoaBcellpopulationthatproducehighlevelsofinterleukin(IL)-10andlowlevelsofinterferon(IFN)-.TransferoftheseBcellsintoDBA/1-TcR-ß-Tgmice,immunizedwithbovinecollagen(CII)emulsifiedincompleteFreund‘sadjuvantinh...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第3期SwappingConnexinGenesHowBigIstheGap
...niversity,Syracuse,NY.: KeyWords:gapjunctionsconductionvelocityconnexin40connexin45atriaManipulationoftheexpressionofspecificgenesintransgenicorknockout(KO)micehasbecomeanimportantstrategytostudythebiologicalandphysiologicalrolesofindividualcardiacproteins.1–3Severallaboratoriesusingtransgenic...
医源资料库;在线期刊;循环研究杂志;2004年第94卷第1期FunctionalcaveolaeareaprerequisiteforCD40signalinginhumanrenalproximaltubulecells
【摘要】TheroleofcaveolaeinCD40/CD154activationofproinflammatorychemokinesandtheirpotentialroleinrenalinflammatorydiseasewereexploredinprimaryculturesofhumanrenalproximaltubuleepithelialcells.Withtheuseofacellfractionationassay,caveolin-1(Cav-1),thedefiningstructuralproteinofcaveolae,wasdetected...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第4期OV系列色谱柱资料(1)
...m×0.10μm1435.20OV-225通用型毛细管色谱柱25m×0.10mm×0.10μm2318.40OV-225通用型毛细管色谱柱15m×0.20mm×0.25μm1117.80OV-225通用型毛细管色谱柱25m×0.20mm×0.25μm1559.40OV-225通用型毛细管色谱柱15m×0.25mm×0.25μm1117.80OV-225通用型毛细管色谱柱25m×0.25m...
药品天地;专业药学;实验技术;色谱技术;仪器介绍与操作Bodymassindexhistoryandriskoftype2diabetes:resultsfromtheEuropeanProspectiveInvestigationintoCancerandNutrition(EPIC)PotsdamStudy
...yagrantfromtheDeutscheKrebshilfe(70-2488-HAI)andbytheEuropeanUnion(SOC95201408OSF02).RecruitmentwassupportedbyagrantfromtheFederalMinistryofResearchandTechnology(01EA9401).3Reprintsnotavailable.AddresscorrespondencetoASchienkiewitz,GermanInstituteofHumanNutrition,DepartmentofEpidemiology,Arthur-Sche...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第2期OV系列色谱柱资料(2)
...m×0.10μm1435.20OV-105通用型毛细管色谱柱25m×0.10mm×0.10μm2318.40OV-105通用型毛细管色谱柱15m×0.20mm×0.25μm1117.80OV-105通用型毛细管色谱柱15m×0.20mm×0.33μm1117.80OV-105通用型毛细管色谱柱15m×0.20mm×0.50μm1435.20OV-105通用型毛细管色谱柱25m×0.20m...
药品天地;专业药学;实验技术;色谱技术;仪器介绍与操作人IL-12的克隆、表达及生物活性的鉴定
...图书分类号 R392.11 摘 要 目的:克隆中国人IL-12p40基因,构建IL-12的真核基因表达载体。方法:采用RT-PCR从北京地区人脐血树突状细胞(DC)中克隆IL-12p40cDNA基因,并进行序列分析。利用pcDNA3.1和pLXPXSN构建IL-12表达载体,转染...
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