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LymphocyterecruitmentintotheaorticwallbeforeandduringdevelopmentofatherosclerosisispartiallyL-selectindependent
...ralLN;Rag-1–/–mice,recombinationactivatinggene1–deficientmice;RBC,redbloodcell;vDC,vascularDC;WD,WesternDiet.Atherosclerosisisaninflammatorydiseaseoflargeandmedium-sizedarteriesthatleadstocharacteristicplaqueformation,rupture,andischemicinjuryofthedependentvascularbed(1,2).Thepossibleinvolveme...
医源资料库；在线期刊；实验医学杂志；2006年第203卷第5期 -
杂交群和封闭群动物的特点及应用
...群动物（Hybridstrain）或杂交一代动物，简称F1动物。如C57BL/6J和DBA/2小鼠交配后培育的第一代动物即为BDF1或B6D2F1；C57L/J和A/He交配后的第一代动物为LAF1等。 2．概念：F1是Firstfilialgeneration的简称，即“杂交一代”或“子一代”，...
医药经济；生物技术；实验技术；动物学技术 -
SustainedNitricOxideSynthesisContributestoImmunopathologyinOngoingMyocarditisAttributabletoInterleukin-0Disorders
...inCVB3-inducedpathogenesisofmyocarditis,wedeterminedtherelationshipofinduciblenitric-oxidesynthase(iNOS)mRNAexpressionwithIFN-andIL-10secretionduringCVB3infectionindifferentmousestrains.WefoundinsusceptibleA.BY/SnJmicethatdevelopongoingmyocarditis,alowanddelayedIFN-secretionandhighlydiminishedIL-10p...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第12期 -
SerialdeterminationofglomerularfiltrationrateinconsciousmiceusingFITC-inulinclearance
...Rwas236.69±16.55and140.20±22.27µl/mininmaleandfemaleC57BL/6Jmice,respectively.Totalornephrectomyreducedinulinclearanceto0or32.80±9.32µl/min,respectively.Conversely,diabetesmellitusinducedbystreptozotocinwasassociatedwithincreasedGFR.Theotherapproachmeasuredurinaryinu...
医源资料库；在线期刊；美国生理学杂志；2004年第287卷第3期 -
RegulationofChemokineExpressionbyNaClOccursIndependentlyofCysticFibrosisTransmembraneConductanceRegulatorinMacrophages
...agestoNaClandLPS.Theresponsesofmacrophagesfrombothstrainswereindistinguishable.Inaddition,CFTRmRNAwasnotexpressedinmacrophages.Takentogether,thesefindingssuggestthatNaClstimulatesMIP-2productionbymacrophagesthroughamechanismthatispartiallydependentonTNF-butindependentofmacrophageCFTRexpression.-----...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第7期 -
IncreasedMelanomaGrowthandMetastasisSpreadinginMiceOverexpressingPlacentaGrowthFactor
...ypelittermates.TransgenicmiceandcontrolswereinoculatedintradermallywithB16-BL6melanomacells.Thetumorgrowthratewasfivefoldincreasedintransgenicanimalscomparedtowild-typemice,inthepresenceofasimilarpercentageoftumornecrotictissue.Tumorvesselareawasincreasedintransgenicmiceascomparedtocontrols.Augmente...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第8期 -
BileAcidsDecreaseHepaticParaoxonase1ExpressionandPlasmaHigh-DensityLipoproteinLevelsViaFXR-MediatedSignalingofFGFR
...bileacidsrepresshepaticexpressionofparaoxonase1(PON1).MethodsandResults-C57BL/6miceandC3H/HeJmice,havingdifferentsusceptibilitiestoatherosclerosis,werefedachowdietandanatherogenicdietcontainingtaurocholate.Comparedwiththemoreatherosclerosis-susceptibleC57BL/6mice,C3H/HeJmicedisplayresistancetodietar...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第2期 -
HypoxicAdipocytesPatternEarlyHeterotopicBoneFormation
...twhiteadipocytesconvertintofat-oxidizingcellswhenbrownadipocytesareunavailable,providingacompensatorymechanismforgenerationofahypoxicmicroenvironment.Manipulationofthetranscriptionalcontrolofadipocytefateinlocalsoft-tissueenvironmentsmayofferameanstopreventortreatdevelopmentofboneinextraskeletalsite...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第2期 -
高渗氯化钠溶液对急性失血性休克家兔血乳酸的影响
...定休克前、休克30min及输液后30min、60min、90min时血乳酸（BL）变化水平。结果高渗氯化钠溶液组在输液后1h内均显著降低血乳酸(P0.05)。结论高渗氯化钠溶液组较0.9%氯化钠溶液组更能显著降低血乳酸，提示急性失血性休克给予高渗...
医源资料库；在线期刊；中华医学实践杂志；2006年第5卷第11期 -
MastCell-DerivedTumorNecrosisFactorCanPromoteNerveFiberElongationintheSkinduringContactHypersensitivityinMice
...ccurbetweenmastcellsandcutaneousnervesduringavarietyofskindisorders.Remarkably,however,relativelyfewstudieshaveassessedtowhatextentsuchpotentialmastcell-nerveinteractionsactuallyareimportantininfluencingspecificfeaturesofindividualcutaneousresponsesordefinedmechanismsthatmightaccountforsignificantin...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第11期