著名华人科学家Cell子刊RNA剪接研究新成果
...个新的激酶家族而为众人瞩目。在国际学术期刊发表论文100多篇,其中10多篇论文发表在Nature、Science、Cell三大顶级期刊上。近年来广泛的基因组测序揭示,在不同的基因组中蛋白质编码基因数量相似且相对有限,从而促使研究...
医药经济;生物技术;技术要闻ScavengerReceptorClassBTypeIMediatestheSelectiveUptakeofHigh-DensityLipoprotein–AssociatedCholesterylEsterbytheLiverinMice
...ely,ie,independentfromparticleinternalization.ClassBtypeIscavengerreceptor(SR-BI)mediatesthisuptakeinvitro.TheroleofSR-BIinHDLmetabolismwasexploredinmice.MethodsandResults—MicewithamutationintheSR-BIgene(SR-BIKO)andwild-type(WT)littermateswereused.MutantshadincreasedHDLcholesterol.HDLwaslabeledwit...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第1期Apoa5Q139Xtruncationpredisposestolate-onsethyperchylomicronemiaduetolipoproteinlipaseimpairment
...teins,whereasinnormalplasma,Apoa5associatedwithVLDLandHDL/LDLfractions.APOB100kineticstudiesin3severelydyslipidemicpatientswithQ139XrevealedamajorimpairmentofVLDLcatabolism.Lipoproteinlipaseactivityandmassweredramaticallyreducedindyslipidemiccarriers,leadingtoseverelipolysisdefect.Ourobservationsstr...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期BaselineCorrelationandComparativeKineticsofCerebrospinalFluidColony-FormingUnitCountsandAntigenTitersinCryptococcalMeningitis
...eatedwithamphotericinB(0.70.8mg/kg/day)aloneorincombinationwithflucytosine(100mg/kg/day),fluconazole(400mg/day),orboth.After2weeks,therapywasswitchedtofluconazole(400mg/dayfor8weeksand200mg/daythereafter).Weperformedfollow-uplumbarpuncturesondays3,7,and14.Anadditional8patients,whoweretreatedatLosAng...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第16期CXCL16/SR-PSOXIsanInterferon-–RegulatedChemokineandScavengerReceptorExpressedinAtheroscleroticLesions
...reremovedbyscraping,washedinPBS0.5%bovineserumalbumin(BSA),andincubatedwith100μg/mLanti-CXCL16antibodiesin100μLPBS/0.5%BSAat4°Cfor20minutesandwashedtwicewithPBS.StainingwasdetectedwithFITC-labeledgoatanti-rabbitantibodies(1:20)(Dakopatts,Clostrup,Denmark).Foranalysisofox-LDLuptake,THP-1cells(0.2x...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第4期高效液相色谱指纹图谱在中药知母上的应用
...计算公式为:Sr=(待测峰i的相对面积/标准样品的总面积)×100。其中,知母8号样品的液相色谱指纹图谱如图1所示。基于8号样品色谱峰总面积较大,峰数较多且具有代表性,将其指定为标准,以求出待测峰i的相对面积。将样品中各组分的...
药品天地;专业药学;中药大全;中药指纹图谱咪达普利治疗高血压
...atmentofmild-to-moderatehypertensionintheelderly.JIntMedRes,2001,29(2):100-107. 5HuangPJ,ChienKL,ChenMF,etal.Efficacyandsafetyofimidaprilinpatientswithessentialhypertension:adouble-blindcomparisonwithcaptopril.Cardiology,2001,95(3):146-150. 6VanderDoesR,EulerR.Arandomized...
资料库;在线期刊;中华现代内科学杂志;2005年第2卷第6期微量元素锶与人体健康
...11例已确诊为晚期恶性肿瘤多发骨转移,并接受氯化锶(89Sr)治疗的患者做了研究,其中前列腺癌1例,乳腺癌2例,肺癌6例,肠癌2例。男6例,女5例。从本组病例治疗后反应的情况来看,治疗后骨痛消失或缓解9例,有效率为90.9%,...
医源资料库;在线期刊;中华医学研究杂志;2012年第12卷第5期Rimonabant:JustanAntiobesityDrug?CurrentEvidenceonItsPleiotropicEffects
...cusscurrentdataonrimonabantactionasamodulatorofreproductivesystemfunctions.1000nM)fortheCB2receptor(Rinaldi-Carmonaetal.,1994).Moreover,itdisplaysaweakaffinitytoGalanin2,MC5,opioid,andpA2receptors(Comptonetal.,1996;Shireetal.,1996).Fig.1.Chemicalstructureofrimonabant.Functionalstudiesconfirmeditspot...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期HepaticexpressionofscavengerreceptorclassBtypeI(SR-BI)isapositiveregulatorofmacrophagereversecholesteroltransportinvivo
...ennsylvania,USA.AbstractHepaticexpressionofthescavengerreceptorclassBtypeI(SR-BI)promotesselectiveuptakeofHDLcholesterolbytheliverandisbelievedtoplayaroleintheprocessofreversecholesteroltransport(RCT).WehypothesizedthathepaticSR-BIexpressionisaregulatoroftherateofintegratedmacrophage-to-fecesRCTandu...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期