AcriticalroleforenhancedTGF-andEGFRexpressionintheinitiationofparathyroidhyperplasiainexperimentalkidneydisease
...renalfailureINCHRONICKIDNEYDISEASE,elevatedserumlevelsofparathyroidhormone(PTH)causeosteitisfibrosa,boneloss,andcardiovascularcomplications,allofwhichcontributesignificantlytoincreasedmorbidityandmortality(8,13,14).Hypocalcemia,hyperphosphatemia,and1,25-dihydroxyvitaminD(calcitriol)deficiencyarethem...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第11期骨髓间充质干细胞研究进展及在软骨组织工程中的应用
...受体、甲状旁腺激素相关蛋白(parathyroidhormone-relatedprotein,PTHrP)及PTH/PTHrP受体、IHH(indianhedgehog)。其中PTHrP与IHH构成负反馈调节机制,IHH主要在肥大软骨前体细胞中表达,可激活PTHrP表达;PTHrP抑制软骨细胞向肥大软骨前体细胞分化。PTHrP/...
医源资料库;在线期刊;中国煤炭工业医学杂志;2007年第10卷第1期生物钟基因的一些非生物钟效应研究进展
...T即zeitgebertime,授时因子时间)。体外观察发现,甲状旁腺素(PTH)能够迅速提高成骨细胞MC3T3E1和软骨细胞ATDC5中Per1mRNA和Per2mRNA水平,但对Per3mRNA无影响。PTH通过蛋白激酶ACRE凝结蛋白信号通路直接mPer的表达[24]。 成骨细胞的活...
医源资料库;在线期刊;成都医学院学报;2010年第5卷第2期EfficacyandsafetyofvitaminD3intakeexceedingthelowestobservedadverseeffectlevel
...ldocumentedaninverserelationbetweenserum25(OH)Dandparathyroidhormone(PTH)concentrations(79).25(OH)Dconcentrations4050nmol/Lareconsideredtobeinsufficient(1012).BecausethesuppressionofPTHisseenasbeneficialforbone,manynowregardserum25(OH)Dconcentrations75100nmol/Lasdesirab...
医源资料库;在线期刊;美国临床营养学杂志;2001年73卷第2期EffectsofahydrogenatedformofvitaminKonboneformationandresorption
...n,proteininducedbyvitaminKabsenceorantagonism(PIVKA-II),parathyroidhormone(PTH),bone-specificalkalinephosphatase(BAP),25-hydroxyvitaminD,and1,25-dihydroxyvitaminD]wereassessedondays1,6(control),21(depletion),and31(repletion)ofeachresidencyperiod.Twenty-fourhoururinecollectionsweremadedailythro...
医源资料库;在线期刊;美国临床营养学杂志;2001年74卷第6期EnhancedresponsetoAVPintheinterlobulararteryfromthespontaneouslyhypertensiverat
...atwassimilartothedistalandcentralpartofAA,whenusingthesameconcentrationofAVPthatwasusedinthepresentstudy(107M).Similartoourdata,Touyzetal.(36)foundanincreasedcontractileresponsetoAVPinthird-orderbranchesofarteriesfromthemesentericbedin17-wk-oldSHRcomparedwithWKYandWistarrats.Incontrasttobaselinecalc...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第5期Associationoflow25-hydroxyvitaminDconcentrationswithelevatedparathyroidhormoneconcentrationsandlowcorticalbonedensityinearlypubertalandpre
...yu.fi.ABSTRACTBackground:Veryfewstudieshaveevaluatedbothparathyroidhormone(PTH)and25-hydroxyvitaminD[25(OH)D]andtheireffectsonbonemassinchildren.Objective:Westudiedtheassociationsofserum25(OH)DandintactPTH(iPTH)withbonemineralcontent(BMC)andbonemineraldensity(BMD)atdifferentbonesitesandtherelationbe...
医源资料库;在线期刊;美国临床营养学杂志;2003年78卷第3期MiceWithaDeletionintheFirstIntronoftheCol1a1GeneDevelopAge-DependentAorticDissectionandRupture
...er.1996;1:9–16.AlvarezM,ThunyakitpisalP,MorrisonP,OnyiaJ,HockJ,BidwellJP.PTH-responsiveosteoblastnuclearmatrixarchitecturaltranscriptionfactorbindstotherattypeIcollagenpromoter.JCellBiochem.1998;69:336–352.HormuzdiSG,PenttinenR,JaenischR,andBornsteinP.Agenetargetingapproachidentifiesafunctionfor...
医源资料库;在线期刊;循环研究杂志;2004年第94卷第1期第二节 常见肾脏疾病的病理生物化学
....9-2.6mmol/L。由于高磷血症,肾生成1,25-(OH)2D3及骨骼对PTH的钙动员作用减弱,因而低钙血症也较常见。中度的高镁血症在ATN病人中也较常见。 ⒎尿毒症症状ATN病人,由于体内氮代谢产物迅速积累,少尿期数日后即可出现尿...
医源资料库;医源图书馆;教材类;临床生物化学VitaminDreceptor-independentFGF23actionsinregulatingphosphateandvitaminDmetabolism
...edusingP-testWakoandCa-testWako,respectively(Wako).Serumparathyroidhormone(PTH)and1,25(OH)2DlevelsweredeterminedusingaRatIntactPTHRIAKit(Immutopics)andanRIAKit(TFB),respectively.TheserumFGF23levelwasmeasuredbysandwichELISA(KainosLaboratory),whichcanquantifytheintactformofFGF23usinghumanrecombinantFG...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第11期