RoleofNedd4-2andpolyubiquitinationinepithelialsodiumchanneldegradationinuntransfectedrenalA6cellsexpressingendogenousENaCsubunits
...epithelialNa+transportinthekidney,lung,andcolon.Thechannelconsistsofthreesubunits(,,and).InMadin-Darbycaninekidney(MDCK)cellsandXenopuslaevisoocytestransfectedwithallthreeENaCsubunits,neuralprecursorcell-expresseddevelopmentallydownregulatedprotein(Nedd4-2)promotesubiquitinconjugationofENaC.Fornativ...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第7期Functionalrolesofcationicaminoacidresiduesinthesodium-dicarboxylatecotransporter3(NaDC-3)fromwinterflounder
...ns232and235werereplacedbyisoleucine(KK232/235II),thetransporterwasexpressedbutshowedsmalltransportratesandsuccinate-inducedcurrents.K114I,locatedwithintransmembranehelix4,showed[14C]succinateuptakesimilartoWTbutrelativelysmallinwardcurrents.WhenK114wasreplacedbyarginine,glutamicacid(E),orglutamine(Q...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第12期ApolipoproteinEInterruptsInterleukin-1ßSignalinginVascularSmoothMuscleCells
【摘要】Objectives-ApolipoproteinE(apoE)exertsantiatherogeniceffectsbutprecisemechanismsremainunclear.WehereinvestigatedtheeffectofapoEonintracellularsignalingbyinterleukin-1ß(IL-1ß),aproinflammatorycytokinepresentinatheroscleroticlesions.MethodsandResults-IL-1ß-inducedexpressi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第7期CooperationofSRC-1andp300WithNF-BandCREBinAngiotensinII-InducedIL-6ExpressioninVascularSmoothMuscleCells
...)playsacrucialroleinvascularinflammationandatherosclerosis.Thishasbeenattributednotonlytoitspressorresponsesbutalsotoitsgrowthpromotingandproinflammatoryactions.1-4AngIIcanprovokeinflammatoryresponsesinthevesselwallasexemplifiedbytheinductionofoxidantstress,5proinflammatorycytokinesandchemokinessuch...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第7期NegativeRegulationofVEGF-InducedVascularLeakagebyBlockadeofAngiotensinIIType1Receptor
...rleakagethroughVEGFreceptor,VEGFR2/Flk-1,mayleadtoedemaandswellingandcontributetomanydiseaseprocessesincludingbraintumors,diabeticretinopathy,ischemicstrokes,sepsis,andalsoinflammatoryconditionssuchasrheumatoidarthritisandasthma.1IthasbeenreportedthatthevascularleakageinducedbyVEGFcouldbeblockedbyac...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第12期UncouplingofEndothelialNitricOxidaseSynthasebyHypochlorousAcid
...othO2·-andONOO-andeNOSdimeroxidationinisolatedmouseaortasfromC57BL/6butlessinthoseofgp91phoxknock-outmice.Finally,inhumancarotidatheroscleroticarteries,eNOSpredominantlyexistedasmonomersinparallelwithincreasedstainingofbothMPOand3-nitrotyrosine.Conclusions-WeconcludethatHOCluncoupleseNOSbyONO...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第12期C-ReactiveProteinInhibitsEndothelium-DependentNO-MediatedDilationinCoronaryArteriolesbyActivatingp38KinaseandNAD(P)HOxidase
...apocynin,orp38kinase(anupstreamactivatorofNAD(P)Hoxidase)inhibitorSB203850,butnotxanthineoxidaseinhibitorallopurinolorJNKinhibitorSP600125,thedetrimentaleffectofCRPonserotonin-induceddilationwasprevented.DihydroethidiumstainingshowedthatCRPproducedSB203850-andTEMPOL-sensitivesuperoxideproductioninth...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第5期Sca-1+ProgenitorsDerivedFromEmbryonicStemCellsDifferentiateIntoEndothelialCellsCapableofVascularRepairAfterArterialInjury
...usly.14ES-D3cellswereculturedontypeIVmousecollagen-coated(Trevigen,Gaithersburg,Md)flasksinbasicdifferentiationmedium(DM)(-minimalessentialmedium;Gibco),supplementedwith10%fetalcalfserum(Gibco)and0.05mmol/L2-mercaptoethanol(Sigma)for3to4days.Asdescribedinpreviousstudies,133to10x105ofstemcellantigen-...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第10期TumorNecrosisFactor-andInterleukin-ßRegulateInterleukin-ExpressioninThirdTrimesterDecidualCells
...ddecidualIL-8expression.Deciduafromchorioamnionitis-complicatedpregnancies,butnottermcontrols,displayedmarkedIL-8immunohistochemicalstainingandadenseneutrophilinfiltrate.Reversetranscriptase-polymerasechainreactionofmicrodissecteddecidualcellsidentifiedIL-8mRNA,confirmingdecidualsynthesisofIL-8.Conf...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第10期ActivatedForkheadTranscriptionFactorInhibitsNeointimalHyperplasiaAfterAngioplastyThroughInductionofp27
...dwithtrypsin,fixedincold90%ethanolfor20minutes,andthenresuspendedinstainingbufferconsistingof1mg/mLRNaseA,20μg/mLpropidiumiodide,and0.01%NP40.DNAcontentwasanalyzedbyflowcytometryonFL-2channelandgatingwassettoexcludedebrisandcellularaggregates.Foreachanalysis,10000eventswerecounted.FKHRL1andCell-Cyc...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第4期