ExpressionoftheKeratinocyteLipidTransporterABCAinDevelopingandReconstitutedHumanEpidermis
...ransporterABCA12areknowntoresultinadeficientskinlipidbarrier,leadingtoharlequinichthyosis(HI).HIisthemostsevereinheritedkeratinizingdisorderandisfrequentlyfatalintheperinatalperiod.ToclarifytheroleofABCA12,ABCA12expressionwasstudiedindevelopinghumanskinandHIlesionsartificiallyreconstitutedinimmunode...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第7期小儿异常Q波30例的临床意义探讨
【摘要】目的探讨小儿异常Q波的临床意义。方法对30例小儿均行常规12导联心电图检查。小儿异常Q波诊断标准为QⅠ2.5mV、QV5、V60.45mV;Q/R比值:Ⅰ、Ⅱ0.25、V5、V60.20;Q0.03s;右胸前导联出现Q波,呈qR、QR或QS形。结果30例由各种疾病所致...
合作平台;在线期刊;中华现代临床医学杂志;2004年第2卷第12A期MultilocusSequenceTypingofKlebsiellapneumoniaeNosocomialIsolates
...rsityMedicalCenterUtrecht,3508GAUtrecht,TheNetherlandsABSTRACTAmultilocussequencetyping(MLST)schemewasdevelopedforKlebsiellapneumoniae.Sequencesofsevenhousekeepinggeneswereobtainedfor67K.pneumoniaestrains,including19ceftazidime-andciprofloxacin-resistantisolates.Fortydistinctallelicprofileswereident...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期Reemergenceofemm1andaChangedSuperantigenProfileforGroupAStreptococciCausingInvasiveInfections:ResultsfromaNationwideStudy
...ococcal(GAS)isolatesfromclinicalmicrobiologicaldepartmentsinDenmarkandsubsequently487(98%)questionnairesfromtheclinicianstreatingthepatientswerereceivedaspartofanationalsurveillance.emmtypesandstreptococcalsuperantigen(SAg)genesweredetermined.TheincidenceofinvasiveGASinfectionswasonaverage2.3per100,...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第4期ThesurvivalkinasesAktandPimaspotentialpharmacologicaltargets
...ases?Manydrugdiscoveryprogramshavebeguntodevelopleadcompoundstoaddressthesequestions.ThisReviewwillexplorethepotentialrisksandbenefitsoftargetingsurvivalkinasesbyoutlining(a)AktandPimkinaseactioninmalignancy,immunity,andvasculardisease,(b)thecommonsubstratesthatsurvivalkinasesshare,(c)recentadvances...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期BlockofC/EBPfunctionbyphosphorylationinacutemyeloidleukemiawithFLT3activatingmutations
...sistanttotheFLT3inhibitortherapies.H.S.RadomskaandD.S.Bassèrescontributedequallytothiswork.Abbreviationsused:AML,acutemyelogenousleukemia;C/EBP,CCAAT/enhancerbindingprotein;ER,estrogenreceptor;ERK,extracellularsignal–regulatedkinase;ITD,internaltandemduplication;MAP,mitogen-activatedprotein;NBT,N...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第2期Mitochondrialenergymetabolisminheartfailure:aquestionofbalance
...roductioninthenormalandfailingheartoccuratthelevelofgeneexpression.Theconsequenceofspecificmetabolicgeneregulatoryeventsasadaptiveversusmaladaptiveinthecontextofmyocardialdiseaseisanareaofintenseinvestigation.Thepurposesofthisreviewaretoprovideabriefoverviewofcardiacenergymetabolicpathwayswithemphas...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第3期SimultaneousDetectionofHepatitisCVirus(HCV)CoreAntigenandAnti-HCVAntibodiesImprovestheEarlyDetectionofHCVInfection
...-HCVAb(seroconversion)duringthefollow-up.Fromthese23individuals,83samplessequentiallycollectedpriortoseroconversionand108samplescollectedafterseroconversionweretested.Sixof12blooddonationswerepositivebytheHCVAg/Abassay.Inthehemodialysiscohort,the24HCVRNA-negativesampleswerenegativebytheHCVAg/Abassay...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期Toll-likereceptor9controlsanti-DNAautoantibodyproductioninmurinelupus
...ntofclinicalautoimmunediseaseornephritis.TheseresultsdemonstrateaspecificrequirementforTLR9inautoantibodyformationinvivoandindicateacriticalroleforinnateimmuneactivationinautoimmunity.Abbreviationsused:ANA,antinuclearantibody;BCR,Bcellreceptor;ds,double-stranded;PAS,periodicacidSchiff;SLE,systemiclu...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第2期TransferandEvaluationofanAutomated,Low-CostReal-TimeReverseTranscription-PCRTestforDiagnosisandMonitoringofHumanImmunodeficiencyVirusType1
...viralload(VL)monitoringtechnologiesinresource-limitedsettings.AnautomatedTaqManreal-timereversetranscription-PCR(RT-PCR)assaywastransferredtothelaboratoryoftheCentredeDiagnosticetdeRecherchessurleSIDA,Abidjan,Cted‘Ivoire,andassessedforHIV-1RNAVLtestingin806plasmasamplescollectedwithinfourANRSresea...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第6期