GeneticEtiologyofIsolatedLowHDLSyndrome
...Objective-Wehaveusedamultitieredapproachtoidentifygeneticandcellularcontributorstohigh-densitylipoprotein(HDL)deficiencyin124humansubjects.MethodsandResults-Weresequenced4candidategenesforHDLregulationandidentifiedseveralfunctionalnonsynonymousmutationsincluding2inapolipoproteinA-I(APOA1),4inlecithi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第5期MitochondrialreactiveoxygenspeciescontributetohighNaCl-inducedactivationofthetranscriptionfactorTonEBP/OREBP
...ousstudiesshowedthathighNaClincreasesreactiveoxygenspecies(ROS),whichcontributetoactivationofTonEBP/OREBP.MitochondriaareamajorsourceofROS.ThepurposeofthepresentstudywastoexaminewhethermitochondriaproducetheROSthatcontributetoactivationofTonEBP/OREBP.WeinhibitedmitochondrialROSproductioninHEK293cell...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期TetrahydrobiopterinandCardiovascularDisease
...oleofBH4inNOSactivityisparticularlyrelevant.ReducedBH4wasfirstshowntocontributetovascularpathophysiologyandhypertension,whereasmorerecentstudieshavefoundimportantrolesincardiachypertrophyandremodeling,andischemia/reperfusionphysiology.DevelopmentofgeneticmousemodelsthatmodulateBH4synthesishavegreatl...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第11期CorrelationbetweenhyperphosphatemiaandtypeIINa-Picotransporteractivityinklothomice
...typemice.Interestingly,transcriptlevelsofthetypeIIa/typeIIctransportermRNAabundance,butnottranscriptslevelsoftypeIIbtransportermRNA,weremarkedlydecreasedinkl/klmicecomparedwithwild-typemice.Furthermore,plasmafibroblastgrowthfactor23(FGF23)levelswere150-foldhigherinkl/klmicethaninwild-typemice.Feedin...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期Collectingduct-specificknockoutofendothelin-1altersvasopressinregulationofurineosmolality
...maNaconcentration,urinevolume,andrenalaquaporin-2(AQP2)levelswereunchanged,butplasmaAVPconcentrationwasreducedinCDET-1KOanimals.CDET-1KOmicehadimpairedabilitytoexcreteanacute,butnotachronic,waterload,andthiswasassociatedwithincreasedCDET-1mRNAincontrol,butnotCDET-1KO,mice.Inresponsetocontinuousinfus...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第5期LowNaintakesuppressesexpressionofCYP2C23andarachidonicacid-inducedinhibitionofENaC
...ressedintheTamm-Horsfallprotein(THP)-positiveandaquaporin2(AQP2)-positivetubules.ThissuggeststhatCYP2C23isexpressedinthethickascendinglimb(TAL)andcollectingduct(CD).NarestrictionsignificantlysuppressedtheexpressionofCYP2C23intheTALandCD.WesternblotalsodemonstratedthattheexpressionofCYP2C23inrenalcor...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第12期Renalvascularendothelialgrowthfactorinneonatalobstructivenephropathy.I.EndogenousVEGF
...lureteralobstruction(UUO)impairsmaturationofthedevelopingkidneyandleadstotubularapoptosisandinterstitialinflammation.Vascularendothelialgrowthfactor(VEGF)isinvolvedinrecoveryfromvariousformsofrenalinjury.WequestionedwhethertherenalexpressionofendogenousVEGFanditsreceptor(VEGFR2/Flk-1)ismodifiedbyUUO...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期VascularEndothelialeCCadherinTyrosinePhosphorylationinAngiogenicandQuiescentAdultTissues
...dulttissues.PhosphorylatedVE-cadherinwasdetectedinmouselung,uterus,andovarybutnotinothertissuesunlessmicewereinjectedwithperoxovanadatetoblockproteinphosphatases.Remarkably,VE-cadherintyrosinephosphorylationwasdramaticallyincreasedinuterusandovary,andnotinotherorgans,duringPMSG/hCG-inducedangiogenes...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第2期SelectiveAgonistsofEstrogenReceptorIsoforms
...stedbytheobservationsthatwomenhaveareducedrelativeCVDriskascomparedwithmen,butthisbenefitislostaftermenopause,whencirculatingestrogenlevelsdecreasedramatically.2Sincethecloningofestrogenreceptors(ERs)andgenerationofERknockoutanimals,severalmediatorsandmechanismshavebeenidentifiedattestingabeneficial...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第10期MyocardinEnhancesSmad3-MediatedTransformingGrowthFactor-1SignalinginaCArGBox-IndependentManner
....AmultimerizedSBEpromoterresponsivetoTGF-1signalingishighlyactivatedbySmad3butnotbythecloselyrelatedSmad2.Intriguingly,myocardin(Myocd),aknownCArGbox-dependentserumresponsefactorcoactivator,participatesinSmad3-mediatedTGF-1signalingandsynergisticallystimulatesSmad3-inducedSBEpromoteractivityindepend...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第11期