LimitedRedundancyinPhosphorylationofRetinoblastomaTumorSuppressorProteinbyCyclin-DependentKinasesinAcuteLymphoblasticLeukemia
...lprogram,andentryofcellsintoSphase.RBunphosphorylatedatserine608hasgrowthsuppressiveactivity.Phosphorylationofserines608/612inhibitsbindingofE2F-1toRB.InNalm-6acutelymphoblasticleukemiaextracts,serine608isphosphorylatedbyCDK4/6complexesbutnotbyCDK2.Wereasonedthatphosphorylationofserines608/612byredu...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期MammalianSkeletalMuscleVoltage-GatedSodiumChannelsAreAffectedbyScorpionDepressant“Insect-Selective“ToxinswhenPreconditioned
...LhqIT2andLqh-dprIT3areeffectiveonrNav1.4whenthechannelisexcitedbeforetoxinapplicationbyeitheralongdepolarizingprepulseorbymodulationwithan-toxin.TheseresultssuggestthatthereportedselectivityofdepressanttoxinstoinsectNavsrestsonthewaytheyweretestedandthatdepressanttoxinsmayhaveatoxicimpactonmammalsin...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期SrcFamilyKinaseActivityIsRequiredforMurineEmbryonicStemCellGrowthandDifferentiation
...einhibitor-1induceddifferentiationofEScellsinthepresenceofLIF.Incontrast,suppressionofallSFKactivitywithhigherconcentrationsoftheseinhibitors,orwiththemorepotentcompoundA-419259(BioorgMedChemLett12:1683-1686,2002)blockeddifferentiationinresponsetoLIFwithdrawal.Itissurprisingthattheseinhibitor-treate...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期他汀类药物临床新应用研究进展
...照研究结果来证实。 7免疫抑制作用 随着移植手术的开展,免疫抑制剂和降血脂药大量的应用,发现Statins具有一定的免疫抑制作用,能够降低移植排斥的发生率并且减缓排斥反应的强度。Statins有可能成为治疗自身免疫性...
医源资料库;在线期刊;中国热带医学杂志;2008年第8卷第9期PulmonaryBloodFlowHeterogeneityduringHypoxiaandHigh-AltitudePulmonaryEdema
...8,000ft).Typically,radiographsinHAPEdemonstrateapatchydistributionofedema,appearingfirstintheperihilarregionsofthelung(2).Thereportedincidenceis2to15%ofexposedindividualsdependingonrateofascentandaltitudereached(3eC5).Riskfactorsincluderapidascent,strenuousexercise,andaprevioushistoryofHAPE.Increase...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第1期InhibitionoftheSrcandJakKinasesProtectsagainstLipopolysaccharide-inducedAcuteLungInjury
...rtthatsystemicinhibitionofthesekinasesusingspecificsmallmoleculeinhibitors(PP2,SU6656,tyrphostinA1)significantlyattenuatedLPS-inducedlunginjury,asdeterminedbyhistologicandcapillarypermeabilityassays.TheseinhibitorsblockedLPS-dependentcytokineandchemokineproductioninthelungandintheserum.Incontrast,lu...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第4期RegulationofMouseHepatic-Amino-β-Carboxymuconate--SemialdehydeDecarboxylase,aKeyEnzymeintheTryptophan-NicotinamideAdenineDinucleotidePathway,by
...hhepatocytenuclearfactor4(HNF4)andperoxisomeproliferator-activatedreceptor(PPAR).ConstitutiveexpressionofACMSDmRNAlevelsweregovernedbyHNF4anddownregulatedbyactivationofPPARbytheligandWy-14,643([4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]aceticacid]),asrevealedbystudieswithhepaticHNF4-nullmiceandPPA...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期椎体成形术的进展
【关键词】椎体成形术椎体成形术经过数十年的临床研究与实践,已从传统手术发展到当今的微创手术,特别是经皮椎体成形术及经皮后凸成形术,已取得了很好的临床疗效,并成为治疗疼痛性椎体损害的一种常用方法。其手术...
医源资料库;在线期刊;中国矫形外科杂志;2009年第17卷第6期抗幽门螺杆菌治疗研究进展
...要二种:①铋盐+抗后素物药物联合;②质子泵抑制剂(PPI)+抗生素联合。具体可有以下多种组合方式(包括中药疗法): 3.1 铋盐+抗微生物药物联合 胶态次枸橼酸铋(CBS),即三钾二枸橼酸铋,已成为治疗Hp感染...
医源资料库;医源图书馆;教材类;中国幽门螺杆菌研究胰腺发育学研究进展
...粉)的β细胞、分泌生长抑素的δ细胞以及分泌胰多肽的PP细胞。内分泌细胞在胰腺细胞总数中占一个较小的比例,在成年鼠中大约只有4%[1]。 胰腺的血供十分丰富,进入胰腺的动脉血穿过各小叶后到达胰岛,然后到达邻近...
医源资料库;在线期刊;局解手术学杂志;2005年第14卷第5期