TyrosinephosphataseMEG2modulatesmurinedevelopmentandplateletandlymphocyteactivationthroughsecretoryvesiclefunction
...spital,Toronto,OntarioM5B1W8,CanadaMEG2,aproteintyrosinephosphatasewithauniqueNH2-terminallipid-bindingdomain,bindstoandismodulatedbythepolyphosphoinositidesPI(4,5)P2andPI(3,4,5)P3.RecentdataimplicateMEG2invesiclefusioneventsinleukocytes.ThroughthegenesisofMeg2-deficientmice,wedemonstratethatMeg2–...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第11期低分子量肝素对重症急性胰腺炎大鼠微循环的影响
...larweightheparinonpancreaticmicrocirculationinsevereacutepancreatitisinratsQiuFu,LvXinsheng,FanQinqiao,etal.DepartmentofGeneralSurgery,XiangyaHospital,CentralSouthUniversity,Changsha410008.【Abstract】ObjectiveToinvestigatetheeffectsoflowmolecularweightheparin(LMWH)onpancreaticmiˉ...
合作平台;在线期刊;中华中西医杂志;2004年第5卷第2期;论著胶南市1992、1997及2002年急性心肌梗死住院病例回顾性调查
...平均年龄由(58.1±10.3)岁上升到(66.4±10.1)岁(F=4.86,q=5.34,P0.05)。1992、1997、2002年住院天数分别为(27.8±34.1)、(19.2±11.7)、(13.7±11.7)d,逐年缩短(F=6.72,q=4.23~5.52,P0.01);发病至入院时间由(29.0±24.7)h缩短为(11.3...
医源资料库;在线期刊;齐鲁医学杂志;2006年第21卷第6期High-Molecular-WeightKininogenFragmentsStimulatetheSecretionofCytokinesandChemokinesThroughuPAR,Mac-1,andgC1qRinMonocytes
...ase(GST)fusionproteinsofkininogendomain3(D3),afragmentofdomain3,E7P(aaG255-Q292),HKdomain5(D5),theD5recombinantpeptidesHG(aaK420-D474)andHGK(aaH475-S626)stimulatedsecretionofIL-1ßfrommononuclearcells.Monoclonalantibodies(MAbs)specificforD5orspecificforD3blockedreleaseofIL-1ßbyHKa,support...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第10期DetectionofAspergillusfumigatusandaMutationThatConfersReducedSusceptibilitytoItraconazoleandPosaconazolebyReal-TimePCRandPyrosequencing
...gnosticLaboratories,L.L.C.,Hamilton,NewJerseyABSTRACTAreal-timePCRandpyrosequencingmethodwasdevelopedtodetectAspergillusfumigatusinwholebloodbyamplifyingthecyp51Ageneandsequencingthecodonforglycine54.Mutationsinthiscodoncanresultinaminoacidsubstitutionsthatconferreducedsusceptibilitytoitraconazolean...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第2期AcyanobacterialLPSantagonistpreventsendotoxinshockandblockssustainedTLR4stimulationrequiredforcytokineexpression
...catethatCyPisapotentcompetitiveinhibitorofLPSinvitroandinvivoandrevealtherequirementofsustainedTLR4stimulationforinductionofcytokinegenesinhumanDCs.Abbreviationsused:CyP,cyanobacterialproduct;PGN,peptidoglican;TLR,Toll-likereceptor.DCscontroltheadaptiveimmuneresponsebyprovidingaquantitativeandqualit...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第6期Thymicstromallymphopoietin:masterswitchforallergicinflammation
...ctivatedDCsinducedrobustproliferationofnaiveallogeneicCD4+Tcells,whichsubsequentlydifferentiatedintoTh2cellsthatproducedtheallergy-promotingcytokinesIL-4,IL-5,IL-13,andTNF,butdidnotproduceIL-10orinterferon-(9).Invivo,TSLPwasshowntobehighlyexpressedbykeratinocytesinatopicdermatitislesionsanditsexpres...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第2期ComparisonofResultsofVoriconazoleDiskDiffusionTestingforCandidaSpecieswithResultsfromaCentralReferenceLaboratoryintheARTEMISGlobalAntifu
...didaspp.thatwerecharacterizedasresistant(MICof4μg/ml)byMICtesting.ExternalqualityassurancedataobtainedbysurveillanceprogramssuchastheARTEMISGlobalAntifungalSurveillanceProgramensurethegenerationofusefulsurveillancedataandresultinthecontinuedimprovementofantifungalsusceptibilitytestingpractices.INTR...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第10期Identifyingprotein–proteininteractionsinsomatichypermutation
...ofMedicine,Bronx,NY10461.Somatichypermutation(SHM)inimmunoglobulingenesisrequiredforhighaffinityantibody–antigenbinding.Culturedcellsystems,mousemodelsystems,andhumangeneticdeficiencieshavebeenthekeyplayersinidentifyinglikelySHMpathways,whereas“pure“biochemicalapproacheshavebeenfarlessprominen...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第4期AntigenrecognitionstrengthregulatesthechoicebetweenextrafollicularplasmacellandgerminalcenterBcelldifferentiation
...BC,sheepredbloodcells;TI-2,T-independenttype2.D.PausandT.G.Phancontributedequallytothispaper.T.G.Phan‘spresentaddressisDept.ofMicrobiologyandImmunology,UniversityofCalifornia,SanFrancisco,SanFrancisco,CA94143.T.D.Chan‘s,S.Gardam‘s,andR.Brink‘spresentaddressisGarvanInstituteofMedicalResearch,...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期