MolecularbasisforthemodulationofnativeT-typeCa2+channelsinvivobyCa2+/calmodulin-dependentproteinkinaseII
...I)toadjustsignaltransmissionbyinducingagatingchangethatischaracterizedbyfrequentchannelopenings(16).CaMKIIexpressionisincreasedinstructuralheartdisease(17),andinhibitionofitsactivityreducesCa2+currentandamelioratesdysfunction(18).IntheZGcell,CaMKIIinducesagatingshiftof1HT-typeCa2+channelsthatenables...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第9期Keyroleofpoly--dl-glutamicacidinimmuneevasionandvirulenceofStaphylococcusepidermidis
...leadingspeciesStaphylococcusepidermidis,arethepredominantcauseofhospital-acquiredinfections.Treatmentisespeciallydifficultowingtobiofilmformationandfrequentantibioticresistance.However,virulencemechanismsoftheseimportantopportunisticpathogenshaveremainedpoorlycharacterized.HerewedemonstratethatS.epi...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第3期栝蒌薤白半夏汤对心肌缺血大鼠内源性血管活性因子及心肌病理形态学影响
【摘要】目的探讨栝蒌薤白半夏汤(GXBD)对心肌缺血大鼠内源性血管活性因子及心肌病理形态学的影响。方法通过结扎大鼠冠状动脉左前降支造成急性心肌缺血模型,用不同剂量的GXBD处理,造模后1h采血测血浆内皮素(ET)和血...
合作平台;在线期刊;中华现代中西医杂志;2005年第3卷第3期;论著兔脑缺血再灌注后细胞凋亡与TIMP-1表达的特点
...凋亡数逐渐增多,缺血12h达高峰,以后逐渐减少(F=14.48,q=4.79~9.39,P<0.01)。缺血1h时脑组织TIMP-1阳性细胞数逐渐增多,48h达高峰(F=52.05,q=4.98~19.43,P<0.01)。动物缺血1h再灌注后,各时间点凋亡细胞数和TIMP-1表达都低于永久性缺血组...
医源资料库;在线期刊;齐鲁医学杂志;2010年第25卷第6期AirwayColonizationbyAcrophialophorafusisporainPatientswithCysticFibrosis
...ns,causedatfirstbyStaphylococcusaureusandthenbyPseudomonasaeruginosa,thatrequiredseveraladmissionstothehospitalforantibioticandrespiratorytherapy.AspergillusfumigatuswasfirstisolatedfrombronchialsecretionsinApril2001,butitwasnotrecoveredinthenextsputumsample1monthlater.Atthistime,culturesyieldedanot...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第3期HistonedeacetylaseactivityisessentialfortheexpressionofHoxA9andforendothelialcommitmentofprogenitorcells
...chostatinA;vWF,vonWillebrandfactor.L.Rssig,C.Urbich,andT.Brühlcontributedequallytothiswork.Endothelialprogenitorcells(EPCs)canoriginatefrombonemarrow–derivedprogenitorcells,circulatewiththebloodonmobilizationfromthebonemarrow,andhometositesofactivevesselgrowth,aprocesstermed“adultvasculogenesis...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第11期TheImpactofHistoryofHypertensionandType2DiabetesatBaselineontheIncidenceofStrokeandStrokeMortality
theDepartmentofEpidemiologyandHealthPromotion(G.H.,C.S.,P.J.,M.P.,Q.Q.,J.T.),NationalPublicHealthInstitute,HelsinkiDepartmentofPublicHealth(G.H.,C.S.,P.J.,M.P.,Q.Q.,J.T.),UniversityofHelsinki,HelsinkiOuluCityHospitalandDepartmentofInternalMedicine(R.A.),OuluUniversity,OuluSouthOstrobothniaCentralHos...
医源资料库;在线期刊;中风学杂志;2005年第36卷第12期TheCablesGeneonChromosomeqIsSilencedbyPromoterHypermethylationandAllelicLossinHumanColorectalCancer
...Cablesisacyclin-dependentkinase-bindingnuclearproteinthatmapstochromosome18q11-12.Here,weassessedCablesexpressionin160colorectalcancers(CRCs),itsroleincoloncancercellgrowth,andthepotentialmechanismsofCablesinactivation.Expressionlevels,promotermethylation,andmutationalstatusofCableswereinvestigatedi...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第11期BreakthroughDisseminatedAspergillusustusInfectioninAllogeneicHematopoieticStemCellTransplantRecipientsReceivingVoriconazoleorCaspofunginProphy
...ePneumologie,HpitalSaint-LouisCentreNationaldeReferenceMycologieetAntifongiques,UnitedeMycologieMoleculaire,CNRSFRE2849,InstitutPasteur,Paris,FranceABSTRACTAspergillusustusisanuncommonclinicalspecieswhichispoorlysusceptibletoantifungals.WereporttwocasesofA.ustusinfectionsthatoccurredinallogeneicstem...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期HIV-1抗体阳性血浆中HIV-1病毒基因分型研究
...plasmaderivedfromalocalhigh-riskpopulationwereinvestigatedbyRT-PCRandcDNAsequencing.TheresultsindicatedthatHIV-1prevalentinalocalhigh-riskpopulationbelongedtoHIV-1subtypeB.ThesequencesofnucleicacidsandaminoacidsinV3loopof6cDNAwerecompletelysimilartothatofThailandHIV-1subtypeBstrains.Besides,theseque...
合作平台;医学论文;临床医学与专科论文;检验医学