HLA-CandKillerCellImmunoglobulin-likeReceptorGenesinIdiopathicBronchiectasis
...quentNKcelldysfunction.Objective:BecausetheHLA-Clocusandkillercellimmunoglobulin-likereceptors(KIRs)areofkeyimportanceforNKcellrecognition,weanalyzedHLA-C/KIRcombinationsbygenotypingpatientswithidiopathicbronchiectasis.Methods:GenomicDNAfrom96individualswithidiopathicbronchiectasisand101controlsubje...
医源资料库;在线期刊;美国呼吸和危急护理医学;2006年第173卷第3期Proteinuriaasadeterminantofrenalexpressionofhemeoxygenase-1:studiesinmodelsofglomerularandtubularproteinuriaintherat
...BSTRACTHemeoxygenase-1(HO-1),acytoprotectivegene,iscommonlyinducedinrenaltubulesinthediseasedkidney.Becauseproteinuriaisahallmarkforkidneydisease,weexaminedtherelationshipbetweenproteinuriaandtubularinductionofHO-1,specificallyquestioningwhetherincreasedtraffickingofproteinacrosstherenaltubularepith...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第1期RoleofLeukotrieneB4ReceptorsintheDevelopmentofAtherosclerosis:PotentialMechanisms
...ia,SchoolofDentalMedicine,Philadelphia,PA.CorrespondencetoDrBodduluriHaribabu,DeliaBaxterBldg,UniversityofLouisville,580SouthPrestonStreet,#119B,Louisville,KY40202.E-mailH0bodd01@gwise.louisville.eduAbstractObjective—LeukotrieneB4(LTB4),apotentleukocytechemoattractant,isknowntopromoteseveralinflam...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第2期Rosuvastatin,butnotSimvastatin,ProvidesEnd-OrganProtectioninStroke-ProneRatsbyAntiinflammatoryEffects
...hbrainabnormalities.Becausedifferencesinhydrophilicity/hydrophobicitycontributetothedifferencesinstatinpharmacology,wealsoevaluatedtheeffectsofsimvastatin,alipophilicmoleculeMethodsandResults—SHRSP,fedahigh-saltdiet,weretreatedlong-termwithvehicleorrosuvastatin(1and10mg/kgperday).Brainabnormalitie...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第3期OxidizedPhospholipids,Lipoprotein(a),Lipoprotein-AssociatedPhospholipaseA2Activity,and10-YearCardiovascularOutcomes
...amRiskScore(FRS).TheeffectsofOxPL/apoBandLp(a)werenotindependentofeachotherbuttheywereindependentofallothermeasuredriskfactors.Conclusions-ThisstudydemonstratesthatOxPL/apoBlevelspredict10-yearCVDeventratesindependentlyoftraditionalriskfactors,hsCRP,andFRS.IncreasingLp-PLA2activityfurtheramplifiesth...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第8期CytolyticTLymphocytes(CTLs)fromHIV-1SubtypeCInfectedIndianPatientsRecognizeCTLEpitopesfromaConservedImmunodominantRegionofHIV-1GagandNef
...owedatrendofinversecorrelationbetweenthemagnitudeoftheresponseandvirusload,butthecorrelationwasnotstatisticallysignificant.Nosignificantassociationwasfoundbetweenvirusloadandbreadthofresponse(P.05).TheCD4+TcellcountalsodidnotshowanysignificantassociationwithHIV-specificTcellresponse.Thestudysubjects...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第17期InvolvementofApoptosisSignal-RegulatingKinase-1onAngiotensinII-InducedMonocyteChemoattractantProtein-1Expression
....ac.jpAbstractObjective—Monocytechemoattractantprotein1(MCP-1)couldcontributetoenhancedleukocyterecruitmentandactivationresultinginchronictissuedamage.However,littleisknownaboutthemolecularmechanismsofcardiacMCP-1expression.Toelucidatethesemolecularmechanisms,angiotensinII-inducedexpressionofMCP-1...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第2期MacrophageABCG1DeletionDisruptsLipidHomeostasisinAlveolarMacrophagesandModeratelyInfluencesAtheroscleroticLesionDevelopmentinLDLReceptor-Defi
...olandphospholipideffluxfrommacrophagestomaturehigh-densitylipoprotein(HDL),butnottolipid-freeapolipoproteins.11,16ABCG1playsacriticalroleinpreventingcellularlipidaccumulationwithinmultipletissuesafteradministrationofahigh-fat,high-cholesteroldiet16andABCG1isexpressedbymacrophage-derivedfoamcellsinth...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第10期Renal20-HETEinhibitionattenuateschangesinrenalhemodynamicsinducedbyL-NAMEtreatmentinpregnantrats
...andL-NAMEsignificantlyattenuatedtheincreasesinMAPandRVRandthedecreaseinGFR,butnotthereductioninRBFinducedbyL-NAMEtreatment.L-NAMEandL-NAMEplusDDMShadnosignificantimpactonrenalhemodynamicsinvirginrats.Inaddition,chronictreatmentwithDDMSselectivelyinhibitedcortical20-HETEproductionwithoutasignificante...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第11期HistoneDeacetylaseInhibitorReducesMonocyteAdhesiontoEndotheliumThroughtheSuppressionofVascularCellAdhesionMolecule-1Expression
...(TNF)-initiatesnumerouschangesinendothelialcell(EC)geneexpressionthatcontributestothepathologyofvariousdiseasesincludinginflammation.WehypothesizedthatTNF--mediatedgeneinductioninvolvesmultiplesignalingpathways,andthatinhibitionofoneormoreofthesepathwaysmayselectivelytargetsubsetsofTNF--responsivege...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第12期