Glucocorticoidssuppressboneformationviatheosteoclast
...ainsinvivo.Hence,wetreatedWTandGRoc–/–micewithparathyroidhormone1–34(PTH1–34),which,consistentwithourinvitroobservations,increasedosteoclastnumberequallyinbothgenotypes,independentofDEX(Figure7A).Ontheotherhand,theinvivoappearanceofPTH1–34–inducedosteoclastsexposedtothesteroidwasstriking...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第8期AnassociationofserumvitaminDconcentrations40nmol/LwithacuterespiratorytractinfectioninyoungFinnishmen
...bemeasured(4).VitaminDinsufficiencyisusuallydeterminedbyparathyroidhormone(PTH)secretion,whichincreaseswhenserum25(OH)Dconcentrationsfallbelow78–100nmol/L(5,6).ThereisagrowingscientificconsensusthatvitaminDinsufficiencyisreachedatserum25(OH)Dconcentrations80nmol/L(7,8).Innorthernclimates,dieti...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第3期骨软化症的99mTc-MDP影像特征
...mol/L),碱性磷酸酶(AKP)1067u/L(25~90u/L),甲状旁腺素(PTH)680pg/ml(8.3~68.0pg/ml)。骨密度检查示股骨及腰椎骨密度降低;颈部B超示双侧甲状腺未见异常,未见增大的甲状旁腺。骨科门诊以全身多发疼痛性质待查申请核医学影...
医源资料库;在线期刊;中华现代影像学杂志;2006年第3卷第1期ResurrectionofvitaminDdeficiencyandrickets
...tinginanincreaseintheexpression,synthesis,andsecretionofparathyroidhormone(PTH)(1,20,22,27).PTHconservescalciumbyincreasingtubularreabsorptionofcalciuminboththeproximalanddistalconvolutedtubules.PTH,like1,25(OH)2D,enhancestheexpressionofRANKLonosteoblaststoincreasetheproductionofmatureosteoclaststom...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第8期氟伐他汀对急性心肌梗死后左室重构的实验研究
...区的截面,放入10%中性甲醛内,24h后石蜡包埋,以做HE和PTH染色。用BHEC显微镜-微机图像分析系统测定左室截面瘢痕弧长,心内膜和心外膜周长,梗死面积=瘢痕弧长/[(外周长+内周长)/2]×100%。1.3统计学方法采用SPSS11.0软件。所...
医源资料库;在线期刊;中华现代内科学杂志;2007年第4卷第2期Effectsofdietarycalciumintakeonbodyweightandprevalenceofosteoporosisinearlypostmenopausalwomen
...lciumconcentrationsinhumanadipocytesafterstimulationwithparathyroidhormone(PTH)and1,25-dihydroxyvitaminD[1,25(OH)2D]isabletoswitchlipidmetabolismfromlipolysistolipogenesis,whichresultsinanincreaseintriacylglycerolstorage.Consistently,1,25(OH)2D,andPTHhavebeenfoundtobepositivelyassociatedwithbodymass...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第3期Characterizationofamurinerenaldistalconvolutedtubulecelllineforthestudyoftranscellularcalciumtransport
...00nM,1,10,and100µM;Fluka,St.Louis,MO),100nMbovineparathyroidhormone(bPTH)(1-34)(Sigma),or10nM1-deamino-8-D-argininevasopressin(dDAVP).Alldrugswereaddedtotheapicalsideaswellastothebasolateralsideofthemonolayer,exceptforRR,whichwasaddedtotheapicalsideonly.Cellswereincubatedat37°Cfor60min.Sub...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第3期益骨散对慢性肾功能不全失代偿期合并肾性骨病患者骨密度的影响
...会随之下降。钙、磷的这种变化导致继发性甲状旁腺素(PTH)分泌亢进,引起骨质疏松、肾性骨病[1,2]。随着血液净化技术的发展,CRF患者生存期逐渐延长,肾性骨病发病率越来越高,是目前影响维持透析患者生存质量的突出问题...
医源资料库;在线期刊;中华现代临床医学杂志;2011年第9卷第1期血管活性肠肽在神经领域的研究进展
...放激素(GHRH)、促肾上腺皮质素释放激素(CRH)、甲状旁腺素(PTH)、胃抑制多肽(GIP)等。VIP与垂体腺苷酸环化酶激肽(PACAP)结构很相似,N末端约68%同源,许多情况下,这2种肽呈现出相似的药理学特性一。VIP在许多代谢活跃的器官表达...
合作平台;医学论文;临床医学与专科论文;药学Identifyinggenesthatregulateboneremodelingaspotentialtherapeutictargets
...6).Therearealsosuggestionsthatsomeoftheanaboliceffectsofparathyroidhormone(PTH)areexertedthroughsuppressionofDickkopf1expression(17).Leptin,acirculatingfactor,whichbindsreceptorsinthehypothalmus,isanotherimportantinhibitorofboneformation.Inastartlingseriesofstudies,ithasbeendemonstratedthatleptinhas...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第6期