RosiglitazoneReducesGlucose-InducedOxidativeStressMediatedbyNAD(P)HOxidaseviaAMPK-DependentMechanism
...ndthatthiseffectwascompletelyabolishedbyRSG.Interestingly,inhibitionofAMPK,butnotPPAR,preventedthiseffectofRSG.AMPKphosphorylationbyRSGwasnecessaryforitsabilitytohamperNAD(P)Hoxidaseactivation,whichwasindispensableforglucose-inducedoxidativestress.DownstreamofAMPKactivation,RSGexertsantioxidativeeff...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第12期CanineCranialReconstructionUsingAutologousBoneMarrowStromalCells
...ntroltransplantsconsistedofHA/TCPparticlesthatweremoistenedwithgrowthmediumbutreceivednocells.TheBMSC-freetransplantswereincubatedwiththesamegrowthmedium(including20%fetalbovineserum)andforthesamelengthoftime(90minutes)asthatusedfortheBMSCtransplants.Themixtureswereincubatedfor90minutesat37??Conaslo...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第2期TheNeurosteroidsDehydroepiandrosteroneSulfateandPregnenoloneSulfateInhibittheUNC-49GABAReceptorthroughaCommonSetofResidues
...ueswererecentlyidentifiedinthefirsttransmembranedomain(M1)ofGABAAreceptorsubunitsthatareimportantforneurosteroidmodulation.WearestudyingtheinhibitionofGABAAreceptorsbysulfatedneurosteroids.Oneoftheseneurosteroid,pregnenolonesulfate(PS),dependsonsixidentifiedM1residuestoinhibittheUNC-49GABAreceptor,a...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期UseofVariable-NumberTandemRepeatsToExamineGeneticDiversityofNeisseriameningitidis
...edisolatesrelatedtotheHajjoutbreakof2000andisolatesrecoveredfromoutbreaksinBurkinaFasoin2001and2002.AllisolateshadbeencharacterizedpreviouslybyMLSTormultilocusenzymeelectrophoresis(MLEE).VNTRanalysisshowedthatmeningococcalisolateswithsimilarMLSTorMLEEtypesrecoveredfromepidemiologicallylinkedcasesina...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第4期Folicacid:influenceontheoutcomeofpregnancy
...uchasaconceptionculminatinginspontaneousabortionorstillbirth,isanunwelcome,butnotanunusual,pregnancyoutcome.Pooroutcomescanalsooccurinpregnanciesthatgiverisetolive-borninfantsandincludepretermdelivery(37wkgestation)andintrauterinegrowthrestriction(10thpercentile),bothofwhichencompassinfantlowbirthwe...
医源资料库;在线期刊;美国临床营养学杂志;2000年71卷第5期HydrogenPeroxide–ScavengingPropertiesofNormalHumanAirwaySecretions
...cretions.Fourfolddilutedsecretionsshowedonlynonenzymaticscavengingactivity,buttheadditionofthiocyanatetothesesamples(0.4mM;substrateforlactoperoxidase)restoredtheirabilitytoscavengeH2O2.Theadditionofreducedglutathione(8µM)onlyenhancednonenzymaticscavengingactivity.Thesedataprovideevidencethatm...
医源资料库;在线期刊;美国呼吸和危急护理医学;2003年第167卷第3期SpreadsupplementedwithmoderatedosesofvitaminEandcarotenoidsreduceslipidperoxidationinhealthy,nonsmokingadults
JaneEUpritchard,CaroelienRWCSchuurman,AnthonyWiersma,LilianBMTijburg,StefanAJCoolen,PhilipJRijkenandSheilaAWiseman1FromtheUnileverHealthInstitute,UnileverResearchandDevelopmentVlaardingen,Vlaardingen,Netherlands2SupportedbyUnileverResearchandDevelopmentVlaardingen.3AddressreprintrequeststoJEUpritcha...
医源资料库;在线期刊;美国临床营养学杂志;2003年78卷第5期RhoBRegulatesPDGFR-βTraffickingandSignalinginVascularSmoothMuscleCells
...r-β(PDGFR-β).BothPDGFR-andPDGFR-βareexpressedinvascularSMCs,butPDGFR-βexpressionishigherandPDGFR-βhasbeenimplicatedinvascularremodeling.1,2PDGFR-βtriggerscellularproliferation,migration,andsurvival3butalsocontributestoatherosclerosis4,5andmalignantneoplasia.6Ligand-indu...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第12期EndothelialOutgrowthCellsAreNotDerivedFromCD133+CellsorCD45+HematopoieticPrecursors
...andphenotypeoftheprecursor(s)thatgiverisetobothcelltypesinvitroandmaycontributetoaconsensusontheirflowcytometricenumeration.MethodsandResults-Usingcellsortingofhumancordblood(UCB)andbonemarrow(BM)cells,wedemonstratethatEOCgeneratingprecursorsareconfinedtoasmallCD34+CD45-cellfraction,butnottotheCD34+...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第7期DecreasedMacrophageParaoxonase2ExpressioninPatientsWithHypercholesterolemiaIstheResultofTheirIncreasedCellularCholesterolContent:EffectofA
...xidativestressandcholesterolcontent,andupregulatedPON2expression,thuscontributingtoattenuationoffoamcellsformation.KeyWords:paraoxonase?oxidativestress?macrophages?cholesterol?atorvastatinIntroductionTheearlyatheroscleroticlesionischaracterizedbyaccumulationofmonocyte-derivedmacrophagesloadedwithcho...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第1期