WhyandhowshouldwemeasureoxidativeDNAdamageinnutritionalstudies?Howfarhavewecome?
...edinvivoandcauseoxidativedamagetoDNAataratethatisprobablyasignificantcontributortotheage-relateddevelopmentofcancer.AgentsthatdecreaseoxidativeDNAdamageshouldthusdecreasetheriskofcancerdevelopment.Thatis,oxidativeDNAdamageisa“biomarker“foridentifyingpersonsatrisk(fordietaryorgeneticreasons,orbot...
医源资料库;在线期刊;美国临床营养学杂志;2000年72卷第5期VascularHemeOxygenase-1InductionSuppressesMicrovascularThrombusFormationInVivo
...heDepartmentofClinical-ExperimentalSurgery(M.D.M.),UniversityofSaarland,Homburg/Saar,Germany.CorrespondencetoDrBrigitteVollmar,DepartmentofExperimentalSurgery,UniversityofRostock,Schillingallee70,18055Rostock,Germany.E-mailbrigitte.vollmar@med.uni-rostock.deAbstractObjective—Byhemedegradation,heme...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第3期MolecularChangesEvokedbyTriethylenetetramineTreatmentintheExtracellularMatrixoftheHeartandAortainDiabeticRats
...HS).Eight-weeksofTETAtreatmentsignificantlyimprovedcardiacdiastolicfunctionbutnot[glucose]plasmaindiabeticanimals.LVandaorticmRNAscorrespondingtoTGF-1,Smad4,collagentypesI,III,andIV,andfibronectin-1,andplasminogenactivatorinhibitor-1,wereelevatedinuntreateddiabeticanimalsandnormalizedafterTETAtreatm...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第12期TPreceptorsregulaterenalhemodynamicsduringangiotensinIIslowpressorresponse
...P-/-hadnormalbasalmeanarterialbloodpressure(MAP)andglomerularfiltrationratebutreducedrenalbloodflowandincreasedfiltrationfraction(FF)andrenalvascularresistance(RVR)andmarkersofROS(thiobarbituricacid-reactivesubstancesand8-isoprostanePGF2)andnitricoxide(NOx).InfusionofANGIIintoTP+/+increasedROSandthr...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第10期Placentaldeliveryofarachidonicanddocosahexaenoicacids:implicationsforthelipidnutritionofpreterminfants
...trition.Deficitsofthekindexperiencedbypreterminfantswouldbeexpectedtocontributetothepathogenesisofthedisordersassociatedwiththecomplicationsofprematurity.NEURODEVELOPMENTALDISORDERSTheriskofdevelopingcentralnervoussystemdefectsrisessharplyasbirthweightfallsbelow1.5kg(1).A4.5-yfollow-upstudyininfants...
医源资料库;在线期刊;美国临床营养学杂志;2000年71卷第1期Polyphenolsinfoodsaremorecomplexthanoftenthought
...dtannins(proanthocyanidins)areparticularlyimportantbecauseoftheirwidedistributioninplantsandtheircontributionstomajorfoodqualities.Allphenoliccompoundsarehighlyunstableandrapidlytransformedintovariousreactionproductswhentheplantcellsaredamaged(forinstance,duringfoodprocessing),thusaddingtothecomplex...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第1期REDD2GeneIsUpregulatedbyModifiedLDLorHypoxiaandMediatesHumanMacrophageCellDeath
...alstudieshaveindicatedthatadiversityofeffectsonmacrophagefunctioncanbeattributedtomodifiedLDL.Theseincludegrowthstimulation,4–6proinflammatoryeffectssuchasexpressionofinflammatorycytokines,7increaseincytotoxicity8andinexpressionofmetalloproteinases,inhibitionofexpressionofinduciblenitricoxidesynth...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第10期PPARGeneTransferSustainsApoptosis,InhibitsVascularSmoothMuscleCellProliferation,andReducesNeointimaFormationAfterBalloonInjuryinRats
...versustheR-group.TheWTsubgroupshowedlessneointimalformationthantheBGcontrolbuttheDNsubgroupshowedmoreneointimalformation(FigureIIA,availableonlineathttp://atvb.ahajournals.org).ImmunofluorescencestainingwasdonetolocalizeGFP(exogenousPPARgeneexpression)bytheuseofanti-GFPantibody(SantaCruz)andfluoresc...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第4期InvolvementofRhoKinaseinEndothelialBarrierMaintenance
...echanismviainactivationofMyosinPhosphatase(MP).Here,weinvestigatedthecontributionofbasalRhokinaseactivitytotheregulationofendothelialbarrierintegrity.MethodsandResults—Usingaphospho-specificantibodyagainstthemyosinphosphatasetargetingsubunit(Thr696–MYPT1)asamarkerforRhokinaseactivity,bas...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第11期RegulationofEndothelialCellandEndothelialProgenitorCellSurvivalandVasculogenesisbyIntegrin-LinkedKinase
...ated.3Thereisaccumulatingevidencethatendothelialprogenitorcells(EPCs)contributetovesselgrowthinischemicandinflamedtissueinadults.4–6Despiteitspromisingapplicationfortissueregeneration,thelimitedendogenouspoolandthepossiblefunctionalimpairmentassociatedwithavarietyofphysiologicalandpathologicalcond...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第6期