Ficollanddextranvs.globularproteinsasprobesfortestingglomerularpermselectivity:effectsofmolecularsize,shape,charge,anddeformability
...eledusingsimpleporemodels(37,45,5153,56),eventhough,recently,anumberofseeminglymoresophisticatedmodelshavebeenpresented(16,26,44).Usingtheso-called“two-poremodel“ofglomerularpermeability,theselectivityoftheGCWischaracterizedbyaverylargenumberofalbumin-restrictive“equivalent“smallpores[radius...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第4期Gestationaldiabetesmellitus
...uatetomeettissuedemandsfornormalbloodglucoseregulation.Studiesconductedduringlatepregnancy,when,asdiscussedbelow,insulinrequirementsarehighanddifferonlyslightlybetweennormalandgestationaldiabeticwomen,consistentlyrevealreducedinsulinresponsestonutrientsinwomenwithGDM(17-23).Studiesconductedbeforeora...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第3期Antigentargetingtodendriticcellselicitslong-livedTcellhelpforantibodyresponses
...estoahapten,(4-hydroxy-3-nitrophenyl)acetyl(NP),afterboostingwithOVA-NP.AsingleDC-targetedimmunizationelicitedlong-livedTcellhelperresponsestothecarrierprotein,leadingtolargenumbersofantibody-secretingcellsandhightitersofhigh-affinityantihaptenimmunoglobulinGs.SmalldosesofDC-targetedOVAinducedhigher...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期Structure-BasedIdentificationofNovelHuman-GlutamylcysteineSynthetaseInhibitors
...thandFriedman,1991).Inparticular,relativeelevationsofGSHand-GCShavebeenstronglyassociatedwithdrugresistanceinovariantumorcells(Lewandowiczetal.,2002).DepletionofGSHbyL-buthionine-(R,S)-sulfoximine(L-BSO)(1,Fig.1),apotentinhibitorof-GCS,canreversedrugresistanceinthesesamecells.Morerecently,GSHandcell...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第4期Consumptionoffermentedandnonfermenteddairyproducts:effectsoncholesterolconcentrationsandmetabolism
...{at}agradm.lan.mcgill.ca.ABSTRACTTheobjectiveofthisarticlewastoreviewexistingliteratureconcerningtheeffectsandmechanismsofactionoffermenteddairyproductsonserumcholesterolconcentrations.Althoughnotwithoutexception,existingevidencefromanimalandhumanstudiessuggestsamoderatecholesterol-loweringactionoff...
医源资料库;在线期刊;美国临床营养学杂志;2000年71卷第3期Carbonmonoxidereversesestablishedpulmonaryhypertension
...lammation,PAH,andvesselwallhypertrophyinresponsetohypoxia(12).ThesedatastronglysuggestthatasolublemediatorgeneratedbyHO-1mediatedtheprotectionaffordedinthepulmonaryvasculature.Thegaseousmoleculecarbonmonoxide(CO),whicharisesendogenouslyfromallcellsviathecatabolismofhemebythehemeoxygenaseenzymes,poss...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第9期AberrantTcelldifferentiationintheabsenceofDicer
...iRNA,precursormicroRNA;RNAi,RNAinterference;siRNA,shortinterferingRNA;SP,singlepositive;YFP,yellowfluorescentprotein.S.A.Muljo,K.M.Ansel,andC.Kanellopouloucontributedequallytothiswork.RNAinterference(RNAi)isanevolutionarilyconservedpathway,centraltoabroadspectrumofbiologicalphenomena,includingdevelo...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第2期TheReducedFolateCarrierGeneIsaNovelSelectableMarkerforRecombinantProteinOverexpression
...m(FergusonandFlintoff,1999).ThehRFCwithacoremolecularmassof65kDacontainsasingleN-linkedglycosylationsiteinthefirstextracellularloopbutundergoesanextensiveN-linkedglycosylation,renderingitabroadlymigratingtransmembraneproteinwithanaveragemolecularmassof85kDa(Freisheimetal.,1992;Wongetal.,1998;Droriet...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第3期Corticotrophin-releasingfactorreceptorswithintheventromedialhypothalamusregulatehypoglycemia-inducedhormonalcounterregulation
...ose-sensingneuronsinwhole-cellcurrentclamprecordingsinbrainslices.Interestingly,thesuppressiveeffectofUCNI–mediatedCRFR2activationpersistedforatleast24hoursafterinvivoVMHmicroinjection.OurdatasuggestthatregulationoftheCRRislargelydeterminedbytheinteractionbetweenCRFR2-mediatedsuppressionandCRFR1-m...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期Osteoblast-derivedPTHrPisapotentendogenousboneanabolicagentthatmodifiesthetherapeuticefficacyofadministeredPTH1–34
...ureofthisosteopenicphenotypeanddelineatethemechanismthatleadstoit,byexamininglongbonesfromthesemiceandWTlittermatesusingquantitativemicro-CT(μCT)anddynamichistomorphometry.At3monthsofage,3DstructureoftrabecularbonewassignificantlyalteredinthePthrp+/–micecomparedwithPthrp+/+littermatesandwasassoci...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第9期