AdenovirusVectorE4GeneRegulatesConnexin40and43ExpressioninEndothelialCellsviaPKAandPI3KSignalPathways
...time-anddose-dependentinductionofjunctionalCx40expressionandsuppressionofCx43proteinandmRNAexpression.TreatmentofECswithPKAinhibitorH89orPI3KinhibitorLY294002preventedtheAdE4+-mediatedregulationofCx40andCx43thatwasassociatedwithdiminishedAdE4+-mediatedsurvivalofECs.Moreover,bothPKAactivityandcAMP-re...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第5期DetectionofCirculatinggp43AntigeninSerumCerebrospinalFluid,andBronchoalveolarLavageFluidofPatientswithParacoccidioidomycosis
...lse-negativeresults.Incontrast,thedetectionofParacoccidioidesbrasiliensisgp43circulatingantigenmayrepresentamorepracticalapproachtotherapiddiagnosisofthedisease.Accordingly,aninhibitionenzyme-linkedimmunosorbentassay(inh-ELISA)wasdevelopedforthedetectionofa43-kDaP.brasiliensis-specificepitopeincorpo...
医源资料库;在线期刊;微生物临床杂志;2003年第41卷第8期DistinctPathwaysRegulateExpressionofCardiacElectricalandMechanicalJunctionProteinsinResponsetoStretch
...retch.Previously,weshowedthatexpressionofthegapjunctionprotein,connexin(Cx)43,isincreasedby2-foldafter1hourofstretch,andthisresponseismediatedbystretch-inducedsecretionofvascularendothelialgrowthfactor(VEGF).Here,wereportthatthemechanicaljunctionproteinsplakoglobin,desmoplakin,andN-cadherinarealsoup...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第8期DevelopmentofOne-Step,Real-Time,QuantitativeReverseTranscriptasePCRAssaysforAbsoluteQuantitationofHumanCoronavirusesOC43and229E
...CR(qRT-PCR)fortherapiddetectionandquantitationofhumancoronaviruses(HCoVs)OC43and229E.Absoluteviralloadmeasurementinclinicalsampleswasachievedthroughtheconstructionofin-houseHCoVOC43and229EcRNAstandardsforthegenerationofastandardcurve.TheHCoVOC43assayallowsquantitationoverarangefrom20to2x108RNAcopies...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第11期关于施行《进口药材管理办法(试行)》有关事宜的通知
...种目录(第一批)序号名称适用标准产地1儿茶《儿茶等43种进口药材质量标准》印度尼西亚、马来西亚、缅甸2西洋参《儿茶等43种进口药材质量标准》加拿大、美国3高丽红参《儿茶等43种进口药材质量标准》韩国4西红花《儿茶...
医源资料库;医药卫生法规大全;药政类(药品、食品、器械);药品法规Cardiac-SpecificLossofN-CadherinLeadstoAlterationinConnexinsWithConductionSlowingandArrhythmogenesis
...plinginthemyocardium.Asignificantdecreaseinthegapjunctionproteins,connexin-43andconnexin-40,wasobservedinN-cadherineCdepletedmyocytes.Perturbationofconnexinfunctionresultedindecreasedventricularconductionvelocity,asdeterminedbyopticalmapping.OurdatasuggestthatperturbationoftheN-cadherin/catenincompl...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第9期AssessmentoftheRolesofSerines5.43(239)and5.46(242)forBindingandPotencyofAgonistLigandsattheHumanSerotonin5-HT2AReceptor
...opoftransmembranehelix5ofthehuman5-HT2Areceptor,comparingthewildtypewithS5.43(239)AorS5.46(242)Amutations.Usingtheergolinelysergicaciddiethylamide(LSD),andaseriesofsubstitutedtryptamineandphenethylamine5-HT2Areceptoragonists,wefoundthatSer5.43(239)ismorecriticalforagonistbindingandfunctionthanSer5.4...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期MolecularModelforStudyingtheUncultivatedFungalPathogenLacazialoboi
...tudyofotherproteins.Wehavedevelopedastrategyforstudyingthegeneencodingthegp43homologousproteinofP.brasiliensisinL.loboi.Thegp43proteinwasselectedbecauseithasbeenfoundthatthisP.brasiliensisantigenstronglyreactswhenitisusedtotestserafrompatientswithlacaziosis.Theprinciplebehindthisideawastoobtainthegp...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期AtypicalSerologicalResponseMarkedbyaLackofDetectableAnti-gp43AntibodiesinaPatientwithDisseminatedParacoccidioidomycosis
...icaltestsarefrequentlyusedtodiagnosisparacoccidioidomycosis.Aglycoproteinof43kDaisconsideredtobethemaindiagnosticantigen,beingrecognizedbyvirtuallyallpatients‘sera.Acaseofatypicalserologicalresponse,consistingofalackofdetectableanti-gp43antibodies,inapatientwithdisseminatedparacoccidioidomycosisis...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第6期研究找到渐冻症相关蛋白致病新证据
上图中,变异的人类TDP-43蛋白为绿色,正常的则为红色。(图片来源:EdwardLee)近日,美国宾夕法尼亚大学医学院神经退行性疾病研究中心的科学家通过研究,首次找到解释TDP-43蛋白发生变异时是如何导致神经细胞死亡的直接证...
行业资讯;临床快报;神经科