RemovalofFkbp12/12.6FromEndothelialRyanodineReceptorsLeadstoanIntracellularCalciumLeakandEndothelialDysfunction
【摘要】Objectives-FK506BindingProtein12anditsrelatedisoform12.6(FKBP12/12.6)stabilizeaclosedstateofintracellularCa2+releasechannels(ryanodinereceptors),andinmyocytesremovalofFKBP12/12.6fromRyRsaltersintracellularCa2+levels.TheimmunosuppressivedrugsrapamycinandFK506bindanddisplaceFKBP12/12.6from...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第7期Transcobalamin776CGpolymorphismnegativelyaffectsvitaminB-12metabolism
...C)776CG]mayaffectthefunctionoftranscobalamin,theproteinrequiredforvitaminB-12cellularuptakeandmetabolism.Remethylationofhomocysteineisdependentontheproductionof5-methyltetrahydrofolateandadequatevitaminB-12forthemethioninesynthasereaction.Objectives:TheobjectivesweretoassesstheinfluenceoftheTC776CGp...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第6期5.11维生素B12
5.11维生素B12 5.11.1结构与性质 维生素B12(VB12)为钴胺素(Cobalamin)类化合物,他的分子中有4个还原性吡咯环联结在一起,这种构叫做咕啉,他与核苷酸(二甲基苯异咪唑)及核糖相联,另一方面与D-1-氨基-2-丙醇相...
医源资料库;医源图书馆;教材类;临床营养学Holo-transcobalaminisanindicatorofvitaminB-12absorptioninhealthyadultswithadequatevitaminB-12status
...eenhypothesizedthattheresponseofholo-transcobalamin(holo-TC)tooralvitaminB-12maybeusedtoassessabsorption.Todevelopareliableclinicalabsorptiontestthatusesholo-TC,itisnecessarytodeterminetheoptimaltimelineforvitaminB-12administrationandpostdoseassessment.Objective:Theobjectiveofthisstudywastoassessthe...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第4期FolateandvitaminB-12statusinrelationtoanemia,macrocytosis,andcognitiveimpairmentinolderAmericansintheageoffolicacidfortification
...olicacidfortificationdelaysthediagnosisoforexacerbatestheeffectsofvitaminB-12deficiency,whichaffectsmanyseniors.Thisideaiscontroversial,however,becauseobservationaldataarefewandinconclusive.Furthermore,experimentalinvestigationisunethical.Objective:WeexaminedtherelationsbetweenserumfolateandvitaminB...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第1期中心性渗出性脉络膜视网膜病变2例治验
...证属湿浊上泛;治以和营健脾,活血利水化痰。处方:生地12g,当归12g,玄参12g,银花12g,蒲公英30g,白术9g,陈皮9g,制半夏9g,白僵蚕12g,猪茯苓各12g,车前子14g,丹参12g,赤芍12g,鸡血藤15g,仙灵脾12g,藁本12g。2004年3月1日复...
合作平台;在线期刊;中华现代临床医学杂志;2004年第2卷第11A期IL-12与急性白血病的相关研究
...有细胞因子网络失衡,机体的免疫状态改变。白细胞介素12(IL-12)是在免疫反应早期的调控因子,它由直接接触抗原的细胞产生,参与机体的免疫状态、促进细胞毒性T淋巴细胞(CTL)和淋巴因子激活的杀伤细胞(LAK)生成、高效诱生IFN-...
医源资料库;在线期刊;中华医学实践杂志;2009年第8卷第2期VitaminB-12status,particularlyholotranscobalaminIIandmethylmalonicacidconcentrations,andhyperhomocysteinemiainvegetarians
...ngeditorialonpage3ABSTRACTBackground:VegetarianshavealowerintakeofvitaminB-12thandoomnivores.EarlyandreliablediagnosisofvitaminB-12deficiencyisveryimportant.Objective:TheobjectivewastoinvestigatevitaminB-12statusinvegetariansandnonvegetarians.Design:Thestudycohortincluded66lactovegetariansorlactoovo...
医源资料库;在线期刊;美国临床营养学杂志;2003年78卷第1期中药治“红眼病”
...则:疏风解表,兼以清热。 方药:羌活胜风汤。柴胡12克,荆芥6克(后下),防风12克,前胡12克,羌活12克,独活12克,薄荷6克(后下),川芎12克,白芷12克,白术12克,甘草6克,枳壳12克,黄芩12克,桔梗12克。水煎服,...
中医中药;中医临床;临床讨论LowvitaminB-12concentrationsinpatientswithoutanemia:theeffectoffolicacidfortificationofgrain
...E-mail:jamesmills{at}nih.gov.ABSTRACTBackground:InsomepatientswithvitaminB-12deficiencymistakenlytreatedwithfolicacid,anemiaresolvedbutneurologiccomplicationsbecameworse(masking).Fortificationofenrichedcerealgrainswithfolicacidhasraisedconcernsthatpeoplewhoconsumelargequantitiesofcerealgrains,partic...
医源资料库;在线期刊;美国临床营养学杂志;2003年77卷第6期