Thephosphoinositide-bindingproteinp40phoxactivatestheNADPHoxidaseduringFcIIAreceptor–inducedphagocytosis

...phate;NBT,nitrobluetetrazolium;PB1,phagocyteoxidaseandBem1p;PEM,peritonealexudatemacrophage;PI3,phosphoinositide3;PI(3)P,phosphatidylinositol-3-phosphate;PRR,proline-richregion.Phagocyticleukocytesareessentialforintactinnateimmunitytobacterialandfungalpathogens.Uponactivationbyeithersolublestimulior...

CriticalRoleoftheCarboxylTerminusofProline-richTyrosineKinase(Pyk2)intheActivationofHumanNeutrophilsbyTumorNecrosisFactor

...edearlyeventsinsmoothmusclecells.Am.J.Physiol.260:C721–C730.Yaffe,M.B.,J.Xu,P.A.Burke,R.A.Forse,andG.E.Brown.1999.Primingoftheneutrophilrespiratoryburstisspecies-dependentandinvolvesMAPkinaseactivation.Surgery.126:248–254.Downey,G.P.,J.R.Butler,H.Tapper,L.Fialkow,A.R.Saltiel,B.B.Rubin,andS.Grins...

YersiniavirulencefactorYopJactsasadeubiquitinasetoinhibitNF-Bactivation

...stablishmentofasystemicinfectionofmice.J.Exp.Med.188:2127–2137.Orth,K.,Z.Xu,M.B.Mudgett,Z.Q.Bao,L.E.Palmer,J.B.Bliska,W.F.Mangel,B.Staskawicz,andJ.E.Dixon.2000.DisruptionofsignalingbyYersiniaeffectorYopJ,aubiquitin-likeproteinprotease.Science.290:1594–1597.Dixit,V.,andT.W.Mak.2002.NF-kappaBsigna...

CriticalRoleoftheCarboxylTerminusofProline-richTyrosineKinase(Pyk2)intheActivationofHumanNeutrophilsbyTumorNecrosisFactorSeparationofSig

...edearlyeventsinsmoothmusclecells.Am.J.Physiol.260:C721–C730.Yaffe,M.B.,J.Xu,P.A.Burke,R.A.Forse,andG.E.Brown.1999.Primingoftheneutrophilrespiratoryburstisspecies-dependentandinvolvesMAPkinaseactivation.Surgery.126:248–254.Downey,G.P.,J.R.Butler,H.Tapper,L.Fialkow,A.R.Saltiel,B.B.Rubin,andS.Grins...

TransmissionofHigh-RiskHumanPapillomavirus(HPV)betweenParentsandInfant:aProspectiveStudyofHPVinFamiliesinFinland

...pillomavirus(HPV)inchildren,butthetransmissionmodesarestillpartlyunknown.Sexualabusehasbeenclaimedtobethesourceofgenitalinfectionsinsomecases(21),butnonsexualmodesofHPVtransmissionalsohavetobeconsidered.Theseincludeverticaltransmissionfromparentstoinfants,horizontaltransmissionfromotherfamilymembers...

PCRDetectionofBacteriaonCardiacValvesofPatientswithTreatedBacterialEndocarditis

...diagnosisofleptospirosis.J.Infect.Dis.172:281-285.Millar,B.M.J.,P.Mallon,J.Xu,M.Crowe,R.McClurg,D.Raoult,J.Earle,R.Hone,andP.Murphy.2001.Moleculardiagnosisofinfectiveendocarditis—anewDuke‘scriterion.Scand.J.Infect.Dis.33:673-680.Morris,A.J.,D.Drinkovic,S.Pottumarthy,M.G.Strickett,D.MacCulloch,N....

RegulationofLysophosphatidicAcidReceptorExpressionandFunctioninHumanSynoviocytes:ImplicationsforRheumatoidArthritis?

...,andJGW-8(C20H39NaBrO6P)weresynthesizedatTheUniversityofUtahbyJ.Gajewiak,Y.Xu,andG.Jiang.Allofthecompoundsaboveweredissolvedinphosphate-bufferedsalinecontaining0.1%fattyacid-freebovineserumalbuminfromSigma,andthealiquotswerestoredat-20°C.ThespecificLPA2agonist,dodecylphosphate,andLPA3agonist,L-s...

Anautosomaldominantmajorgeneconferspredispositiontopulmonarytuberculosisinadults

...N.Miller,G.F.Black,C.S.Peacock,H.J.Cordell,J.M.Howson,M.A.Shaw,D.Burgner,W.Xu,Z.Lins-Lainson,etal.2004.Evidenceforaclusterofgenesonchromosome17q11-q21controllingsusceptibilitytotuberculosisandleprosyinBrazilians.GenesImmun.5:46–57.Bucheton,B.,L.Abel,S.El-Safi,M.M.Kheir,S.Pavek,A.Lemainque,andA.J.D...

Interleukin(IL)-4inhibitsIL-10topromoteIL-12productionbydendriticcells

...ateautoimmunitybyprovisionofIL-10.Nat.Immunol.3:944–950.Yee,C.S.,Y.Yao,Q.Xu,B.McCarthy,D.Sun-Lin,M.Tone,H.Waldmann,andC.-H.Chang.2005.EnhancedproductionofIL-10bydendriticcellsdeficientinCIITA.J.Immunol.174:1222–1229.Gourley,T.S.,S.Roys,N.W.Lukacs,S.L.Kunkel,R.A.Flavell,andC.-H.Chang.1999.Anovelr...

乳腺癌干细胞与乳腺癌关系的研究进展

...选出具有特殊表面标志的细胞注入免疫缺陷小鼠的体内，结果发现所有接种ESA+、CD44+、CD24-/low、Lin-细胞的小鼠在12周内均出现明显的肿瘤，而接种CD44-/CD24+细胞的小鼠则少有肿瘤生长。同时，在将接种免疫缺陷小鼠后生成的肿瘤...