Identificationofaninterleukin(IL)-25–dependentcellpopulationthatprovidesIL-4,IL-5,andIL-13attheonsetofhelminthexpulsion
...logy,CambridgeCB22QH,England,UKType2immunity,whichinvolvescoordinatedregulationofinnateandadaptiveimmuneresponses,canprotectagainsthelminthparasiteinfection,butmayleadtoallergyandasthmaafterinappropriateactivation.Wedemonstratethatil25–/–micedisplayinefficientNippostrongylusbrasiliensisexpulsion...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期ReactiveAldehydeModificationofThioredoxin-ActivatesEarlyStepsofInflammationandCellAdhesion
...tedwithdevelopmentofatherosclerosis.Acroleinand4-hydroxynonenal(HNE)arereactivealdehydesgeneratedduringactiveinflammationasaconsequenceoflipidperoxidation;bothreactwithproteinthiols,includingthioredoxin-1(Trx1),aproteinrecentlyfoundtoregulateantioxidantfunctioninendothelialcells.Thepresentstudyexami...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第11期RegulationoftheExpressionofHumanOrganicAnionTransporter3byHepatocyteNuclearFactor1/andDNAMethylation
【关键词】RegulationHumanorganicaniontransporter3(hOAT3/SLC22A8)ispredominantlyexpressedintheproximaltubulesofthekidneyandplaysamajorroleintheurinaryexcretionofavarietyoforganicanions.ThepromoterregionofhOAT3wascharacterizedtoelucidatethemechanismunderlyingthetissue-specificexpressionofhOAT3.Th...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期Humanskincellssupportthymus-independentTcelldevelopment
...archCenterandDepartmentofDermatology,BrighamandWomen’sHospital,HarvardInstitutesofMedicine,Boston,Massachusetts,USA.AbstractThymictissuehaspreviouslybeenconsideredarequirementforthegenerationofafunctionalanddiversepopulationofhumanTcells.Wereportthatfibroblastsandkeratinocytesfromhumanskinarrayedo...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第11期Ornithinemetabolisminmaleandfemaleratkidney:mitochondrialexpressionofornithineaminotransferaseandarginaseII
...picstudies.Ornithineaminotransferase(OAT)andAIIwerelocalizedusingspecificantibodies.OrnithineoxidationwasdeterminedbyincubatingmicrodissectedtubuleswithL-[1-14C]orL-[U-14C]ornithineinthepresenceorabsenceofenergy-providingsubstrates.Ornithinedecarboxylase(ODC)mRNAswerelocalizedbyinsituhybridization.T...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第4期AframeshiftpolymorphisminP2X5elicitsanallogeneiccytotoxicTlymphocyteresponseassociatedwithremissionofchronicmyeloidleukemia
...versityNijmegenMedicalCentre,Nijmegen,TheNetherlands.2DepartmentofHumanGenetics,UniversityofUtah,SaltLakeCity,Utah,USA.3DepartmentofHematology,LeidenUniversityMedicalCenter,Leiden,TheNetherlands.4DepartmentofHematology,NijmegenCentreforMolecularLifeSciences,RadboudUniversityNijmegenMedicalCentre,Nij...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第12期阻断乙型肝炎病毒母婴宫内传播对血清病毒DNA和转录体影响的研究
...别扩增HBV-DNA和RNA,琼脂糖凝胶电泳显示产物,Southern-blotting验证反应的特异性,取代表性产物克隆、测序,检测血清HBV-DNA及全长型(fRNA)和顿挫性转录体。结果治疗组和对照组新生儿外周血中HBsAg、HBV-DNA、fRNA和trRNA的阳性率分...
合作平台;在线期刊;中华现代临床医学杂志;2005年第3卷第9期Cholesterol-LikeEffectsofSelectiveCyclooxygenaseInhibitorsandFibratesonCellularMembranesandAmyloid-Production
【关键词】Cholesterol-LikeStrongevidencesuggestsamechanisticlinkbetweencholesterolmetabolismandtheformationofamyloid-peptides,theprincipalconstituentsofsenileplaquesfoundinthebrainsofpatientswithAlzheimer‘sdisease.Here,weshowthatseveralfibratesanddiarylheterocyclecyclooxygenaseinhibitors,amon...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第7期Inductionandblockageofoligodendrogenesisbydifferentlyactivatedmicrogliainananimalmodelofmultiplesclerosis
1DepartmentofNeurobiology,WeizmannInstituteofScience,Rehovot,Israel.2KaplanMedicalCenter,Rehovot,Israel.3ProneuronBiotechnologies,NessZiona,Israel.4DepartmentofImmunology,WeizmannInstituteofScience,Rehovot,Israel.AbstractTheroleofactivatedmicroglia(MG)indemyelinatingneurodegenerativediseasessuchasmu...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第4期Lightchaineditinggeneratespolyreactiveantibodiesinchronicgraft-versus-hostreaction
...ologyResearch,UniversityofChicago,Chicago,IL606372LaboratoryofMolecularGeneticsandImmunology,TheRockefellerUniversity,NewYork,NY10021Thechronicgraft-versus-host(cGvH)reactionisamodelofinducedlupuscausedbyalloreactiveCD4+TcellsfromaBm-12mouseinaC57BL/6recipient.WeusedthiscGvHreactioninC57BL/6anti-DNA...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期