LossofSOCS3inThelpercellsresultedinreducedimmuneresponsesandhyperproductionofinterleukin10andtransforminggrowthfactor–1
1DivisionofMolecularandCellularImmunology,MedicalInstituteofBioregulation,2ResearchInstituteforDiseasesoftheChest,GraduateSchoolofMedicalSciences,3DepartmentofParasitology,FacultyofMedicalSciences,KyushuUniversity,Higashi-ku,Fukuoka812-8582,JapanSuppressorofcytokinesignaling(SOCS)3isamajornegativefe...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期CD40inducesmacrophageanti–Toxoplasmagondiiactivitybytriggeringautophagy-dependentfusionofpathogen-containingvacuolesandlysosomes
1DivisionofInfectiousDiseases,DepartmentofInternalMedicine,UniversityofCincinnatiCollegeofMedicine,Cincinnati,Ohio,USA.2CenterforTropicalandEmergingGlobalDiseases,UniversityofGeorgia,Athens,Georgia,USA.AbstractManyintracellularpathogens,includingToxoplasmagondii,survivewithinmacrophagesbyresidinginv...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第9期Anti-CD3andnasalproinsulincombinationtherapyenhancesremissionfromrecent-onsetautoimmunediabetesbyinducingTregs
1DepartmentofDevelopmentalImmunology-3,LaJollaInstituteforAllergyandImmunology,SanDiego,California,USA.2NaomiBerrieDiabetesCenter,DivisionofEndocrinologyandDepartmentofMedicine,CollegeofPhysiciansandSurgeons,ColumbiaUniversity,NewYork,NewYork,USA.3DiabetesCenter,DepartmentofMedicine,UCSF,SanFrancisc...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期RapGAPInhibitsTumorGrowthinOropharyngealSquamousCellCarcinoma
【摘要】Rap1,agrowthregulatoryproteinthatisstronglyexpressedinhumansquamouscellcarcinoma(SCC),isinactivatedbyrap1GAP.Recentevidenceinnormalratcellssuggeststhatrap1GAPregulatesproliferation.Theobjectiveofthecurrentstudywastoin-vestigatewhetherrap1GAPfunctionsasatumorsuppressorinSCC.Usingapull-dow...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第2期AdjuvantIL-7orIL-15overcomesimmunodominanceandimprovessurvivaloftheCD8+memorycellpool
1PediatricOncologyBranch,CenterforCancerResearch,NationalCancerInstitute,Bethesda,Maryland,USA.2DepartmentofPediatricHematology-Oncology,S.OrsolaHospital,UniversityofBologna,Bologna,Italy.3MetabolismBranch,CenterforCancerResearch,NationalCancerInstitute,Bethesda,Maryland,USA.AbstractCurrentmodelsofT...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第5期Phosphatidylinositol3,4,5-trisphosphate:anearlymediatorofinsulin-stimulatedsodiumtransportinA6cells
【摘要】InsulinstimulatessodiumtransportacrossA6epithelialcellmonolayers.Activationofphosphatidylinositol3-kinase(PI3-kinase)wassuggestedasanearlystepintheinsulin-stimulatedsodiumreabsorption(Ref.35).ToestablishthatthestimulationofthePI3-kinasesignalingcascadeiscausingstimulationofapicalepitheli...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第8期Alterationsinregulationofenergyhomeostasisincyclicnucleotidephosphodiesterase3B–nullmice
1Pulmonary-CriticalCareMedicineBranch(PCCMB),NationalHeart,Lung,andBloodInstitute(NHLBI),NIH,Bethesda,Maryland,USA.2DepartmentofExperimentalMedicalScience,LundUniversity,Lund,Sweden.3DiabetesBranch,NIDDK,NIH,Bethesda,Maryland,USA.Addresscorrespondenceto:YoungHunChoi,PCCMB,NHLBI,NIH,9000RockvillePike...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第12期Indoleamine2,3-dioxygenase–expressingdendriticcellsformsuppurativegranulomasfollowingListeriamonocytogenesinfection
...MolecularTumorBiologyandTumorImmunologyattheClinicIforInternalMedicine,2InstituteforMedicalMicrobiology,ImmunologyandHygiene,3InstituteforPathology,4InstituteforNeurophysiology,5InstituteforBiochemistryII,and6CenterforMolecularMedicine,UniversityofCologne,Cologne,Germany.7InstituteofMedicalMicrobiol...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第12期CompleteFcRndependenceforintravenousIgtherapyinautoimmuneskinblisteringdiseases
...choolofMedicine,ChapelHill,NorthCarolina,USA.AbstractNumerousmechanismsofactionhavebeenproposedforintravenousIg(IVIG).Inthisstudy,weusedIgGpassivetransfermurinemodelsofbullouspemphigoid(BP),pemphigusfoliaceus(PF),andpemphigusvulgaris(PV)totestthehypothesisthattheeffectofIVIGinautoantibody-mediatedcu...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第12期StaphylococcusaureusPanton-ValentineleukocidindirectlytargetsmitochondriaandinducesBax-independentapoptosisofhumanneutrophils
1CentreNationaldeRéférencedesStaphylocoques,INSERME0230,Lyon,France.2INSERMU503,BiosciencesLyonGerland,Lyon,France.3LaboratoiredePhysiopathologieetd’AntibiologiedesInfectionsBactériennesEmergentesetNosocomiales–EA3432,InstitutdeBactériologiedelaFacultédeMédecine–H?pitauxUniversitairesdeS...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第11期