Oxygen,oxidativestress,hypoxia,andheartfailure
...herbeneficialorcontributetocardiacdysfunctionanddeath.Asoxygenisamajordeterminantofcardiacgeneexpression,andacriticalparticipantintheformationofROSandnumerousothercellularprocesses,considerationofitsroleintheheartisessentialinunderstandingthepathogenesisofcardiacdysfunction.Themammalianheartisanobli...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第3期TissueFactor–FactorVIIaSignaling
...easeactivatedreceptors(PARs).RecentstudiesusingvariouscellmodelsystemsandlimitedinvivosystemsarebeginningtodefinehowTF–VIIa-inducedsignalingregulatescellularbehavior.SignalingpathwaysinitiatedbybothTF–VIIaproteaseactivationofPARsandphosphorylationoftheTF–cytoplasmicdomainappeartoregulatecellul...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第1期Bradykinin-InducedNuclearFactorofActivatedT-Cells-DependentTranscriptioninRatDorsalRootGanglionNeurons
...ptorfunctionbyactivatingmembersofthenuclearfactorofactivatedT-cells(NFAT)familyoftranscriptionfactors.BradykininactivationofB2receptorsevokedconcentration-dependent(EC50=6.0±0.3nM)increasesinintracellularCa2+concentration([Ca2+]i)inaproportionofdorsalrootganglionneuronsinprimaryculture.These[...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第8期Heterogeneousdistributionofchloridechannelsalongthedistalconvolutedtubuleprobedbysingle-cellRT-PCRandpatchclamp
...al.Weusedheresingle-cellRT-PCRandpatchclamptoprobeCl-channelheterogeneityinmicrodissectedmouseDCTatthemolecularandfunctionallevels.Ourfindingsshowthat63%oftheDCTcellsexpressClC-K2mRNA,eitheralone(type1cells:47and23%inDCT1andDCT2,respectively),orcombinedwithClC-K1,mostlyinDCT2(type2cells:33%),but37%o...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第12期ModulationofHepaticInflammatoryRiskMarkersofCardiovascularDiseasesbyPPAR-Activators
...eceptors(PPAR)areligand-activatedtranscriptionfactorsthatbelongtothesuperfamilyofnuclearreceptors.1PPARsareactivatedbynaturalligandssuchasfattyacids,eicosanoids,andoxidizedfattyacids.2-6Ofthe3PPARfamilymembers,PPAR-,PPAR-ß/,andPPAR-,PPAR-isthetargetofthelipid-loweringfibrates.3,7PPARsregulateg...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第5期RelatingTCR-peptide-MHCaffinitytoimmunogenicityforthedesignoftumorvaccines
...ofColoradoatDenverandHealthSciencesCenter,Denver,Colorado,USA.2DepartmentofMicrobiology,Immunology,andPathology,ColoradoStateUniversity,FortCollins,Colorado,USA.3TorreyPinesInstituteforMolecularStudies,SanDiego,California,USA.AbstractOneapproachtoenhancingtheTcellresponsetotumorsisvaccinationwithmim...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第9期AMouseModelforStudyingtheInteractionofBisdioxopiperazineswithTopoisomeraseIIinVivo
...ousrecombination.ThesecellswereusedforthegenerationoftransgenicTOP2AY165S/+mice,whichweredemonstratedtoberesistanttowardthegeneraltoxicityofbothICRF-187andICRF-193.HematologicalmeasurementsindicatethatthisismostlikelycausedbyadecreasedabilityoftheseagentstoinducemyelosuppressioninTOP2AY165S/+mice,hi...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期Roleofmitochondrialglucocorticoidreceptoringlucocorticoid-inducedapoptosis
...GR)mediatesglucocorticoid(GC)-inducedapoptosisareunknown.WestudiedtheroleofmitochondrialGRinthisprocess.DexamethasoneinducesGRtranslocationtothemitochondriainGC-sensitive,butnotinGC-resistant,Tcelllines.Incontrast,nuclearGRtranslocationoccursinallcelltypes.Thymicepithelialcells,whichcauseapoptosisof...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期AThrombospondin-AntagonistofTransformingGrowthFactor-ßActivationBlocksCardiomyopathyinRatswithDiabetesandElevatedAngiotensinII
【摘要】Indiabetesandhypertension,theinductionofincreasedtransforminggrowthfactor-ß(TGF-ß)activityduetoglucoseandangiotensinIIisasignificantfactorinthedevelopmentoffibrosisandorganfailure.WeshowedpreviouslythatglucoseandangiotensinIIinducethelatentTGF-ßactivatorthrombospondin-1...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第9期TheEffectofLowpHonBreastCancerResistanceProtein(ABCG2)-MediatedTransportofMethotrexate,7-Hydroxymethotrexate,MethotrexateDiglutamate,FolicAc
...rda-BCRPmembranevesicles,weshowedthattheATP-dependentvesiculartransportof1µMmethotrexatebyBCRPis5-foldhigheratpH5.5thanatphysiologicalpH.ThetransportofmethotrexatewassaturableatpH5.5,withapparentKmandVmaxvaluesof1.3±0.2mMand44±2.5nmol/mgofprotein/min,respectively,butwaslinearwith...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期