COX-2activitytransientlycontributestoincreasedwaterandNaClexcretioninthepolyuricphaseafterreleaseofureteralobstruction
...-2activitycontributestopolyuriaandimpairedurine-concentratingcapacity.WeexaminedtheeffectoftheselectiveCOX-2inhibitorparecoxib(5mg·kg-1·day-1viaosmoticminipumps)onrenalfunctionsandproteinabundanceofAQP2,AQP3,Na-K-2Clcotransportertype2(NKCC2),andNa-K-ATPase3daysafterreleaseofBUO.At3days...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第5期CriticalroleofendothelialP-selectinglycoproteinligand1inchronicmurineileitis
...ascularResearchCenter,3DepartmentofBiomedicalEngineering,4InternalMedicine,MicrobiologyMolecularPhysiologyandBiologicalPhysics,UniversityofVirginiaHealthSciencesCenter,Charlottesville,VA22908L-selectinligandsmightberelevantforinflammatorycelltraffickingintothesmallintestineinaspontaneousmodelofchron...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期B7-H4expressionidentifiesanovelsuppressivemacrophagepopulationinhumanovariancarcinoma
1DepartmentofSurgery,UniversityofMichigan,AnnArbor,MI481092TulaneUniversityHealthSciencesCenter,NewOrleans,LA701123LouisiannaStateUniversityHealthSciencesCenter,NewOrleans,LA701124DepartmentofDermatology,SidneyKimmelComprehensiveCancerCenter,TheJohnsHopkinsUniversity,Baltimore,MD21287Tumor-associate...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期PurineReleasefromSpinalCordMicrogliaafterElevationofCalciumbyGlutamate
【关键词】PurineReleaseThepropagationofCa2+wavesinanetworkofmicroglialcells,afteritsinitiationbyglutamate,ismediatedbypurinergictransmission.Inthisstudy,weinvestigatedthemechanismsbywhichglutamatereleasesATPfromculturedspinalcordmicroglia.The4-foldincreaseinATPreleasefrommicrogliainresponsetogl...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期Apoptosis-InducingLigand-InducedApoptosisbyUp-RegulationofCaspase-WithoutAlteringChemosensitivity
...RAIL-andchemotherapy-mediatedapoptosisinEwing??ssarcoma.Usingimmunohistochemistry,weshowthatlowexpressionofcaspase-8isseeninabout24%oftumors.Interferon-inducesexpressionofcaspase-8atconcentrationsachievableinhumansandsensitizescellstoTRAIL.Transfectionofwildtypebutnotmutantcaspase-8intocaspase-8-def...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第6期Cadherin-InducesRheumatoidArthritisFibroblast-LikeSynoviocytestoFormLiningLayersinVitro
...ideevidencethatcadherin-11expressedinfibroblast-likesynoviocytesplaysadeterminingroleinestablishingthesynoviallininglayer.Fibroblast-likesynoviocytesthatweregrowninthree-dimensionalmatricesdemonstratedformationofaliningstructureattheinterfacebetweenthematrixandthefluidphase.Treatmentoffibroblast-lik...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第5期CharacteristicsofGinsenosideRg3-MediatedBrainNa+CurrentInhibition
...emolecularmechanismsunderlyingRg3-inducedNa+channelinhibition.Weusedthetwo-microelectrodevoltage-clamptechniquetoinvestigatetheeffectofRg3onNa+currents(INa)inXenopuslaevisoocytesexpressingwild-typeratbrainNaV1.2and1subunits,ormutantsinthechannelentrance,theporeregion,thelidocaine/tetrodotoxin(TTX)bi...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第4期Carcinoembryonicantigen-relatedcelladhesionmolecule1modulatesvascularremodelinginvitroandinvivo
1DepartmentofClinicalChemistry,CenterofClinicalPathology,UniversityMedicalCenterHamburg-Eppendorf,Hamburg,Germany.2McGillCancerCenter,McGillUniversity,Montreal,Quebec,Canada.3DepartmentofMedicineII,AngiologyandCardiology,UniversityMedicalCenterSchleswig-Holstein,CampusLubeck,Lubeck,Germany.4Centerof...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期Grp78isessentialfor11-deoxy-16,16-dimethylPGE2-mediatedcytoprotectioninrenalepithelialcells
...tentnephrotoxicandnephrocarcinogenicmetaboliteofhydroquinone.WehavenowdeterminedtheabilityofDDM-PGE2toprotectagainstotherrenaltoxicantsandreportthatDDM-PGE2onlyprotectsagainstoncoticcelldeath,inducedbyH2O2,iodoacetamide,andTGHQ,butnotagainstapoptoticcelldeathinducedbycisplatin,mercuricchloride,ortum...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第12期Vasarectavoltage-gatedNa+channelNav1.3isregulatedbycalmodulin
...xpressatetrodotoxin(TTX)-sensitivevoltage-operatedNa+(NaV)conductance.WeexaminedexpressionofNaVisoformsinDVRandtestedforregulationofNaVcurrentsbycalmodulin(CaM).RT-PCRinisolatedpermeabilizedDVRusingdegenerateprimerstargetedtoTTX-sensitiveisoformsamplifiedaproductwhosesequenceidentifiedonlyNaV1.3.Imm...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期