LSP1isanendothelialgatekeeperofleukocytetransendothelialmigration
...ertaT2N4N1,Canada2CellandMolecularBiologyDivision,TorontoWesternResearchInstitute3DepartmentofImmunology,UniversityofToronto,Toronto,OntarioM5T2S8,CanadaLeukocyte-specificprotein1(LSP1),anF-actinbindingproteinandamajordownstreamsubstrateofp38mitogen-activatedproteinkinaseaswellasproteinkinaseC,hasbe...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期Kidneystonedisease
1RenalSection,UniversityofChicago,Chicago,Illinois,USA.2DepartmentofAnatomy,IndianaUniversity,Indianapolis,Indiana,USA.AbstractAbout5%ofAmericanwomenand12%ofmenwilldevelopakidneystoneatsometimeintheirlife,andprevalencehasbeenrisinginbothsexes.Approximately80%ofstonesarecomposedofcalciumoxalate(CaOx)...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期AngiotensinIIAT1receptorblockadedecreasesvasopressin-inducedwaterreabsorptionandAQP2levelsinNaCl-restrictedrats
【关键词】vasopressin-inducedTheWaterandSaltResearchCenter,InstituteofAnatomy,andInstituteofClinicalMedicine,UniversityofAarhus,Aarhus,DenmarkDepartmentofBiochemistryandCellBiology,KyungpookNationalUniversitySchoolofMedicine,Taegu,KoreaLaboratoryofKidneyandElectrolyteMetabolism,NationalHeart,Lu...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第4期p53andATM/ATRRegulate7,12-Dimethylbenz[a]anthracene-InducedImmunosuppression
【关键词】p53Thetumorsuppressorproteinp53isatranscriptionfactorthatregulatesapoptoticresponsesproducedbygenotoxicagents.Previousstudieshavereportedthat7,12-dimethylbenz[a]anthracene(DMBA)-inducedbonemarrowtoxicityisp53-dependentinvivo.OurlaboratoryhasshownthatDMBA-inducedsplenicimmunosuppressio...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第1期EnhancingGlutamateTransport:MechanismofActionofParawixin1,aNeuroprotectiveCompoundfromParawixiabistriataSpiderVenom
...sstudieshaveshownthatacompoundpurifiedfromthespiderParawixiabistriatavenomstimulatestheactivityofglialglutamatetransportersandcanprotectretinaltissuefromischemicdamage.Tounderstandthemechanismbywhichthiscompoundenhancestransport,weexamineditseffectsonthefunctionalpropertiesofglutamatetransportersaft...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期Hematopoieticstemcellsproliferateuntilafterbirthandshowareversiblephase-specificengraftmentdefect
1TerryFoxLaboratory,BCCancerAgency,Vancouver,BritishColumbia,Canada.2DepartmentofMedicalGenetics,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada.AbstractTheregulationofHSCproliferationandengraftmentoftheBMisanimportantbutpoorlyunderstoodprocess,particularlyduringontogeny.Hereweshowthati...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期AutoreactivemarginalzoneBcellsarespontaneouslyactivatedbutlymphnodeBcellsrequireTcellhelp
...ogy,WashingtonUniversitySchoolofMedicine,St.Louis,MO63110InK/BxNmice,arthritisisinducedbyautoantibodiesagainstglucose-6-phosphate-isomerase(GPI).ToinvestigateBcelltolerancetoGPIinnonautoimmunemice,weincreasedtheGPI-reactiveBcellfrequencyusingalowaffinityanti-GPIHchaintransgene.Surprisingly,anti-GPIB...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期KSHVtargetsmultipleleukocytelineagesduringlong-termproductiveinfectioninNOD/SCIDmice
...actTodevelopananimalmodelofKaposisarcoma–associatedherpesvirus(KSHV)infectionuniquelysuitedtoevaluatelongitudinalpatternsofviralgeneexpression,celltropism,andimmuneresponses,weinjectedNOD/SCIDmiceintravenouslywithpurifiedvirusandmeasuredlatentandlyticviraltranscriptsindistalorgansoverthesubsequent...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第7期SAPregulatesTcell–mediatedhelpforhumoralimmunitybyamechanismdistinctfromcytokineregulation
1NationalHumanGenomeResearchInstitute2NationalInstituteofAllergyandInfectiousDisease(NIAID),NationalInstitutesofHealth(NIH),Bethesda,MD208923DivisionofVaccineDiscovery,LaJollaInstituteforAllergyandImmunology,SanDiego,CA92121X-linkedlymphoproliferativediseaseiscausedbymutationsaffectingSH2D1A/SAP,ana...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第6期CD4+CD25+Tcellsprotectagainstexperimentallyinducedasthmaandalterpulmonarydendriticcellphenotypeandfunction
1DivisionofImmunobiology,CincinnatiChildren‘sHospitalMedicalCenter,Cincinnati,OH452292DivisionofMolecularImmunology,CincinnatiChildren‘sHospitalMedicalCenter,Cincinnati,OH45229TheroleofnaturalCD4+CD25+regulatoryT(Treg)cellsinthecontrolofallergicasthmaremainspoorlyunderstood.WeexploretheimpactofT...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第11期