IsolationandStructure-Activityofμ-ConotoxinTIIIA,APotentInhibitorofTetrodotoxin-SensitiveVoltage-GatedSodiumChannels
【关键词】µ-Conotoxinµ-Conotoxinsarethree-looppeptidesproducedbyconesnailstoinhibitvoltage-gatedsodiumchannelsduringpreycapture.Usingpolymerasechainreactiontechniques,weidentifiedagenesequencefromthevenomductofConustulipaencodinganewµ-conotoxin-TIIIA(TIIIA).A125I-TIIIAbindingassayw...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期TNF-SuppressesProlyl-4-Hydroxylase1ExpressionviatheASK1-JNK-NonOPathway
...sandaorticaneurysms.MethodsandResults-Inthecurrentstudy,weshowedthat,whenadministeredindosesof1to100ng/mL,TNF-dose-dependentlydownregulatedtheexpressionofprolyl-4-hydroxylaseI[P4H(I)]-therate-limitingsubunitfortheP4Henzymeessentialforprocollagenhydroxylation,secretion,anddepositioninprimaryhumanaort...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第8期InhibitionofpMitogen-ActivatedProteinKinaseandTransformingGrowthFactor-ß/SmadSignalingPathwaysModulatestheDevelopmentofFibrosisinAdria
【摘要】Inflammationandfibrogenesisarethetwodeterminantsoftheprogressionofrenalfibrosis,thecommonpathwayleadingtoend-stagerenaldisease.Thep38mitogen-activatedproteinkinase(MAPK)andtransforminggrowthfactor(TGF)-ß1/Smadsignalingpathwaysplaycriticalrolesininflammationandfibrogenesis,respectiv...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第11期High-andlow-affinitytransportofL-leucineandL-DOPAbytheheteroaminoacidexchangersLAT1andLAT2inLLC-PK1renalcells
【摘要】ThepresentstudyexaminedthefunctionalcharacteristicsoftheinwardandoutwardL-[14C]DOPAandL-[14C]leucinetransportersinLLC-PK1cells.UptakewasinitiatedbytheadditionofHanks‘mediumwithagivenconcentrationofL-[14C]DOPAorL-[14C]leucine.Saturationexperimentswereperformedincellsincubatedfor6minwith...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第8期MicroglialRecruitmentActivationandProliferationinResponsetoPrimaryDemyelination
...gthetoxincuprizone,whichcausesreproducibledemyelinationinthecorpuscallosum.MicrogliaweredistinguishedfrommacrophagesbyrelativeCD45expression(CD45dim)usingflowcytometry.TheirexpansionoccurredrapidlyandsubstantiallyoutnumberedinfiltratingmacrophagesandTcellsthroughoutthecourseofcuprizonetreatment.Weus...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期BAGDeficiencyResultsinFulminantMyopathyandEarlyLethality
【摘要】Bcl-2-associatedathanogene3(BAG3)isamemberofaconservedfamilyofcyto-protectiveproteinsthatbindtoandregulateHsp70familymolecularchaperones.Here,weshowthatBAG3isprominentlyexpressedinstriatedmuscleandcolocalizeswithZ-disks.Micewithhomozygousdisruptionofthebag3genedevelopednormallybutdeterio...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期MolecularDeterminantsofPyrantelSelectivityinNicotinicReceptors
【关键词】MolecularDeterminantsNicotinicreceptors(acetylcholinereceptors,AChRs)playkeyrolesinsynaptictransmissionthroughoutthenervoussystem.AChRsmediateneuromusculartransmissioninnematodes,andtheyaretargetsforantiparasiticdrugs.Theanthelminticagentslevamisoleandpyrantel,whicharepotentagonistsof...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期GolgiFragmentationandCellDeathfromOverexpressionofWild-TypeandMutantOptineurininTwoOcularCellTypes
...larmeshworkandretinalpigmentepithelialcells.ItlocalizedinsteadinthecytoplasminadiffusepatternwithoutadistinctassociationwiththeGolgiapparatus.Whenoverexpressed,however,wild-typeOPTN-greenfluorescentprotein(GFP)formedfociespeciallyaroundtheGolgi,colocalizingpartiallywiththecommonendocyticpathwaymarke...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期UncoveringthePharmacologyoftheGProtein-CoupledReceptorGPR40:HighApparentConstitutiveActivityinGuanosine5‘-O-(3-[35S]thio)triphosphateBindingS
...ngdifferentligandon-rates,whereastheadditionoffattyacid-freebovineserumalbuminreducedsignals,presumablybybindingthefattyacids.Toalloweffectiveligandequilibration,GPR40-Gqwasusedinguanosine5‘-O-(3-[35S]thio)triphosphate([35S]GTPS)bindingassays.AfterexpressionofGPR40-GqinHEK293cellsandmembraneprepar...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第4期RateofGranulocyteMacrophageColony-StimulatingFactorinHostDefenseAgainstPulmonaryCryptococcusneoformansInfectionduringMurineAllergicBronchopul
...inoculationofCryptococcusneoformans.PulmonaryC.neoformansinfectionofC57BL/6miceisanestablishedmodelofanallergicbronchopulmonarymycosis.OurobjectivewastodeterminewhetherGM-CSFregulatesthepulmonaryTh2immuneresponseinC.neoformans-infectedC57BL/6mice.Long-termpulmonaryfungistasiswaslostinGM-CSFknockout(...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第3期