c-AblKinaseRegulatesCurcumin-InducedCellDeaththroughActivationofc-JunN-TerminalKinase
...AblCurcumin,anaturalphenoliccompoundfoundinturmeric(Curcumalonga)exhibitsanticancerproperties,attributedtoitsantiproliferativeandapoptosis-inducingactivity.Theubiquitouslyexpressednonreceptortyrosinekinasec-AblregulatesstressresponsesinducedbyoxidativeagentssuchasionizingradiationandH2O2.Inthisstudy...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期DevelopmentalcontrolofCD8+Tcell–aviditymaturationinautoimmunediabetes
1DepartmentofMicrobiologyandInfectiousDiseasesandJuliaMcFarlaneDiabetesResearchCentre,FacultyofMedicine,UniversityofCalgary,Calgary,Alberta,Canada.2DepartmentofMedicalMicrobiologyandImmunology,UniversityofAlberta,Edmonton,Alberta,Canada.3DepartmentofMicrobiologyandImmunologyandDepartmentofMedicine,D...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期Criticalroleofstearoyl-CoAdesaturase–1(SCD1)intheonsetofdiet-inducedhepaticinsulinresistance
...archCenter,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,USA.2ISISPharmaceuticals,Carlsbad,California,USA.AbstractStearoyl-CoAdesaturase–1(SCD1)catalyzesthesynthesisofmonounsaturatedfattyacidsfromsaturatedfattyacids.MicewithatargeteddisruptionofScd1genelocusareleananddisplayincreasedinsulinsensiti...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期MicronutrientsandverticaltransmissionofHIV-
MicheleLDreyfussandWafaieWFawzi1FromtheDepartmentsofNutrition(MLDandWWF)andEpidemiology(WWF),HarvardSchoolofPublicHealth,Boston.2SupportedbytheNationalInstituteofChildHealthandHumanDevelopment(NICHDR0132257)andatraininggrantfromtheNationalInstitutesofHealth(DK07703).3AddressreprintrequeststoMLDreyfu...
医源资料库;在线期刊;美国临床营养学杂志;2002年75卷第6期NF-Btranslocationpreventshostcelldeathafterlow-dosechallengebyLegionellapneumophila
1HowardHughesMedicalInstitute2DepartmentofMolecularBiologyandMicrobiology,TuftsUniversitySchoolofMedicine,Boston,MA02111Legionellapneumophila,thecausativeagentofLegionnaires‘disease,growswithinmacrophagesandmanipulatestargetcellsignaling.FormationofaLegionella-containingreplicationvacuolerequirest...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第9期Grp78isessentialfor11-deoxy-16,16-dimethylPGE2-mediatedcytoprotectioninrenalepithelialcells
...otectagainstotherrenaltoxicantsandreportthatDDM-PGE2onlyprotectsagainstoncoticcelldeath,inducedbyH2O2,iodoacetamide,andTGHQ,butnotagainstapoptoticcelldeathinducedbycisplatin,mercuricchloride,ortumornecrosisfactor-.DDM-PGE2-mediatedcytoprotectionisassociatedwiththeupregulationofatleastfiveproteins,in...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第12期FHL2inhibitstheactivatedosteoclastinaTRAF6-dependentmanner
...umderUniversit?tFreiburg,Freiburg,Germany.4DepartmentofExperimentalTherapeutics,TheUniversityofTexas,MDAndersonCancerCenter,Houston,Texas,USA.5DepartmentofMedicine,WashingtonUniversitySchoolofMedicine,St.Louis,Missouri,USA.AbstractTNFreceptor–associatedfactor6(TRAF6)associateswiththecytoplasmicdom...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期Chapter4-NaturalSelection
Chapter4-NaturalSelection:Howwillthestruggleforexistence,discussedtoobrieflyinthelastchapter,actinregardtovariation?Cantheprincipleofselection,whichwehaveseenissopotentinthehandsofman,applyinnature?Ithinkweshallseethatitcanactmosteffectually.Letitbeborneinmindinwhatanendlessnumberofstrangepeculiar...
医源资料库;医源图书馆;教材类;The Origin of SpeciesRolesforHLAandKIRpolymorphismsinnaturalkillercellrepertoireselectionandmodulationofeffectorfunction
...uralBiology,SchoolofMedicine,StanfordUniversity,Stanford,CA943052HistocompatibilityLaboratories,TheAnthonyNolanTrustand3DepartmentofHaematology,TheRoyalFreeHospital,London,NW32QG,England,UKInteractionsbetweenkillercellimmunoglobulin-likereceptors(KIRs)andhumanleukocyteantigen(HLA)classIligandsregula...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期Oxidativestress,renalinfiltrationofimmunecells,andsalt-sensitivehypertension:allforoneandoneforall
【摘要】RecentevidenceindicatesthatinterstitialinfiltrationofTcellsandmacrophagesplaysaroleinthepathogenesisofsalt-sensitivehypertension.Thepresentreviewexaminesthisevidenceandsummarizestheinvestigationslinkingtherenalaccumulationofimmunecellsandoxidativestressinthedevelopmentofhypertension.Them...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第4期