RoleofEndogenousXAP2ProteinontheLocalizationandNucleocytoplasmicShuttlingoftheEndogenousMouseAhb-1ReceptorinthePresenceandAbsenceofLiga
...hemouseAhb-1receptorunderendogenousstoichiometry.TheAhb-1receptoriscytoplasmic,anditbecomespredominantlynuclearafter30to60minofligandexposurewithminimaldegradation.Duringthistime,XAP2coprecipitateswiththeAHR,suggestingthatitdoesnotaffectthenuclearlocalizationoftheligandedreceptor.OverexpressionofXAP...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期Nod1actsasanintracellularreceptortostimulatechemokineproductionandneutrophilrecruitmentinvivo
...mentofPathology,ComprehensiveCancerCenter,2DepartmentofUrology,UniversityofMichiganMedicalSchool,AnnArbor,MI481093DepartmentofChemistry,GraduateSchoolofScience,OsakaUniversity,Toyonaka,Osaka560-0043,Japan4DepartmentofMolecularBiologyandBiotechnology,UniversityofSheffield,SheffieldS102TN,England,UK5A...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期SmallMoleculeDisruptionofGProteinβSubunitSignalingInhibitsNeutrophilChemotaxisandInflammation
...etofinterestforanti-inflammatorypharmaceuticaldevelopment.Inthisstudy,weexaminedwhethersmall-moleculeinhibitionofGβ-dependentsignaling,includingGβ-dependentactivationofPI3-kinaseandRac1,couldinhibitchemoattractant-dependentneutrophilmigrationinvitroandinflammationinvivo.Small-moleculeG&bet...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期Protectionoftransplant-inducedrenalischemia-reperfusioninjurywithcarbonmonoxide
...mpartprotectionagainstoxidativestress.WehypothesizedthatCOwouldprotectischemia-reperfusion(I/R)injuryoftransplantedorgans,andtheefficacyofCOwasstudiedintheratkidneytransplantationmodel.ALewisratkidneygraft,preservedinUniversityofWisconsinsolutionat4°Cfor24h,wasorthotopicallytransplantedintosynge...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第11期Povertyandobesity:theroleofenergydensityandenergycosts
...nowskiandSESpecter1FromtheCenterforPublicHealthNutrition,DepartmentsofEpidemiologyandMedicine,UniversityofWashington,Seattle(AD),andtheUSDepartmentofAgricultureWesternHumanNutritionResearchCenter,UniversityofCalifornia,Davis(SES)2AddressreprintrequeststoADrewnowski,NutritionalSciencesProgram,305Rait...
医源资料库;在线期刊;美国临床营养学杂志;2004年79卷第1期CDIdentifiesPerivascularMacrophagesinNormalandViralEncephaliticBrainsandPotentialPrecursorstoPerivascularMacrophagesinBlood
...detectiondifferentiatesperivascularfromresidentbrainmacrophages(parenchymalmicroglia),nosinglemarkerdistinguishesperivascularmacrophagesinhumansandmice.Here,wepresentthemacrophagescavengerreceptorCD163asamarkerforperivascularmacrophagesinhumans,monkeys,andmice.CD163wasprimarilyconfinedtoperivascular...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第3期CellulardistributionofthepotassiumchannelKCNQ1innormalmousekidney
...edusingNorthernandWesternanalyses,RT-PCRofisolatedtubules,andimmunohistochemistry.NorthernblotsdemonstratedKCNQ1transcriptsinwholekidney.RT-PCRshowedKCNQ1mRNAinisolateddistalconvolutedtubule(DCT),connectingsegment(CNT),collectingducts(CD),andglomeruli.Immunoblotsofkidneyandstomachrevealeda75-kDaprot...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期SignalTransducerandActivatorofTranscriptionbPromotesMucosalToleranceinPediatricCrohn??sDiseaseandMurineColitis
...wereexposedtoGHinshort-termorganculture.Trinitrobenzenesulfonicacid(TNBS)administrationwasusedtoinducecolitisinSTAT5b-deficientmiceandwild-typecontrols,withandwithoutrosiglitazonepretreatment.GHreceptor,STAT5b,PPAR,andnuclearfactorBactivationandexpressionweredetermined.EpithelialcellGHreceptorexpres...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期EssentialRoleforClassIIPhosphoinositide3-kinase-IsoforminCa2+-Induced,Rho-andRhoKinase-DependentRegulationofMyosinPhosphataseandContraction
【关键词】EssentialThelaserconfocalfluorescentmicroscope-basedobservationofcontractileresponsesingreenfluorescentprotein-expressingdifferentiatedvascularsmoothmusclecells,combinedwiththeRNAinterference-mediatedgene-silencingtechnique,allowedustodeterminetheroleofphosphoinositide3-kinase(PI3K)cl...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期Nullmutationinmacrophagemigrationinhibitoryfactorpreventsmusclecelllossandfibrosisinpartialbladderoutletobstruction
...on(pBOO)arebothassociatedwithsmoothmuscledegenerationandfibrosis.Macrophagemigrationinhibitoryfactor(MIF),animportantmediatorofbladderinflammation,hasbeenshowntopromotefibroblastsurvivalandmuscledeathinothertissues.WeevaluatedthehypothesisthatMIFhassimilaractionsinthebladderbystudyingdetrusorrespons...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第12期