PotentModulationoftheVoltage-GatedSodiumChannelNav1.7byOD1,aToxinfromtheScorpionOdonthobuthusdoriae
...cesasubstantialpersistentcurrent.Nav1.8wasnotaffectedbyconcentrationsupto2µM,whereasNav1.3wassensitiveonlytoconcentrationshigherthan100nM.OD1impairstheinactivationprocessofNav1.3withanEC50valueof1127nM.Finally,theeffectsofOD1werecomparedwithaclassic-toxin,AahIIfromAndroctonusaustralisHectorand...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期ThePhenotypicDifferentiationofLocusCeruleusNoradrenergicNeuronsMediatedbyBrain-DerivedNeurotrophicFactorIsEnhancedbyCorticotropinReleasingFa
...ofnoradrenergicneuronsattestedbythepresenceoftyrosinehydroxylase(TH)anddopamine--hydroxylaseandtheabsenceofphenylethanolamineN-methyl-transferase.Althoughinactiveinitself,theneuropeptidecorticotropinreleasingfactor(CRF)stronglyamplifiedtheeffectofBDNF,increasingthenumberofcellsexpressingTHandtheacti...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期LinkingofAutophagytoUbiquitin-ProteasomeSystemIsImportantfortheRegulationofEndoplasmicReticulumStressandCellViability
...quitinatedproteinaggregates.Autophagywaslikelyactivatedinresponsetoendoplasmicreticulumstresscausedbymisfoldedproteinsduringproteasomeinhibition.SuppressionofamajorunfoldedproteinresponsepathwaymediatedbyIRE1byeithergenedeletionorRNAinterferencedramaticallysuppressedtheactivationofautophagybyproteas...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第8期DifferentialRolesofPhosphoinositide-DependentProteinKinase-1andAkt1ExpressionandPhosphorylationinBreastCancerCellResistancetoPaclitaxel,Doxo
...paclitaxel,doxorubicin,andgemcitabine.OverexpressionofPDK1orAkt1conferredsimilarresistancetotreatmentwithpaclitaxelordoxorubicincomparedwithcontrolcells.However,thePDK1-overexpressingcellsweremoreresistanttogemcitabinethanweretheAkt1-overexpressingcells.Wenextcorrelatedtheexpressionandactivation-spe...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期TumorSignalingtotheBoneMarrowChangesthePhenotypeofMonocytesandPulmonaryMacrophagesduringUrethane-InducedPrimaryLungTumorigenesisinA/JMice
...要】Littleisknownabouthowthecompositionofstromalcellswithinthelungcancermicroenvironmentvariesduringtumorprogression.Weexaminedbyimmunohistochemistryeachofsixdifferentstromalcellpopulationsduringthedevelopmentofchemicallyinducedprimarylungcancerinmice.Bloodvesselswereseeneveninmicroscopiclesions,a...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第2期第十一章 免疫细胞化学在神经科学中的应用
...多肽以外,还可用以确定其它的疑义神经递质(Neurotransmitterchemicalsuspect)的性质和分布,包括5—HT及其有关酶类、γ—氨基丁酸(GABA)、甘氨酸、天门冬氨酸和牛磺酸等。 近年来,重组DNA工程与免疫细胞相结合而发展起来...
医源资料库;医源图书馆;教材类;实用免疫细胞与核酸CharacterizationoftheregulationofrenalNa+/H+exchangerNHE3byinsulin
...phorylationandtheinsulineffectcanbeblockedbythePI3Kinhibitorwortmanninoradominant-negativeSGK1.WeshowedthatSGK1transcriptandproteinareexpressedinratproximaltubuleandOKcells.WepreviouslyshowedthatglucocorticoidsaugmenttheeffectofinsulinonNHE3(KlisicJ,HuMC,NiefV,ReyesL,FusterD,MoeOW,AmbuhlPM.AmJPhysio...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期BacterialDiversityinCasesofLungInfectioninCysticFibrosisPatients:16SRibosomalDNA(rDNA)LengthHeterogeneityPCRand16SrDNATerminalRestrictio
...tmentofLifeSciences,King‘sCollegeLondon,LondonSE19NN,1DepartmentofMedicalMicrobiologyandGenitourinaryMedicine,UniversityofLiverpool,LiverpoolL693GA,2RegionalAdultCysticFibrosisUnit,TheCardiothoracicCentre,LiverpoolL143PE,UnitedKingdom,4SiliconGenetics,RedwoodCity,California940633Received18December...
医源资料库;在线期刊;微生物临床杂志;2003年第41卷第8期CerebralmicrocirculationshearstresslevelsdetermineNeisseriameningitidisattachmentsitesalongtheblood–brainbarrier
...ehypothesisthatdragforcesencounteredbythemeningococcusinthebloodstreamdetermineitsattachmentsiteinvessels.WethereforeinvestigatedtheabilityofN.meningitidistobindtoendothelialcellsinthepresenceofliquidflowmimickingthebloodstreamwithalaminarflowchamber.Strikingly,averagebloodflowsreportedforvariousorg...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期Alterationofintra-pancreatictarget-organspecificitybyabrogationofAireinNODmice
...ology,JapanScienceandTechnologyCorp.,Saitama,Japan.AbstractFactorsthatdeterminethespectrumoftargetorgansinvolvedinautoimmunedestructionarepoorlyunderstood.Althoughlossoffunctionofautoimmuneregulator(AIRE)inthymicepithelialcellsisresponsibleforautoimmunity,thepathogenicrolesofAIREinregulatingtarget-o...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期