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Anti-CD63antibodiessuppressIgE-dependentallergicreactionsinvitroandinvivo
...tivationinthiscomplexprovidesaCa2+-independentsignalfordegranulationbysubsequentactivationofPDK-1andtheCa2+-independentproteinkinaseC-(PKC).SeveralinhibitoryreceptorssuppressFcRI-inducedMCfunctions.TheyincludetheMCfunction–associatedmoleculeMAFA,gp49BI,FcRIIB,andthepairedimmunoglobulin-likerecepto...
医源资料库；在线期刊；实验医学杂志；2005年第201卷第3期 -
RegulationofnaturalcytotoxicitybytheadaptorSAPandtheSrc-relatedkinaseFyn
1LaboratoireduDéveloppementNormaletPathologiqueduSystèmeImmunitaire,UnitéInstitutNationaldelaSantéetdelaRechercheMedicale429,HpitalNeckerEnfants-Malades,75015Paris,France2InternationalAgencyforResearchonCancer,69372Lyon,France3ClinicalResearchInstituteofMontréal,Montréal,QuébecH3G146,CanadaSA...
医源资料库；在线期刊；实验医学杂志；2005年第202卷第1期 -
RegulationofosteoclastfunctionandbonemassbyRAGE
...resentevidenceforaroleofRAGEinosteoclastmaturationandfunction,whichhasconsequencesforboneremodeling.MicelackingRAGEhadincreasedbonemassandbonemineraldensityanddecreasedboneresorptiveactivityinvivo.Invitro–differentiatedRAGE-deficientosteoclastsexhibiteddisruptedactinringandsealingzonestructures,im...
医源资料库；在线期刊；实验医学杂志；2006年第203卷第4期 -
Cyclooxygenase-2ExpressionandInhibitioninAtherothrombosis
...ionofCOX-2inthecellularplayersofatherothrombosis,itsroleasadeterminantofplaque“vulnerability,“andtheclinicalconsequencesofCOX-2inhibition.Recentstudiesfromourgroupsuggestthatvariableexpressionofupstreamanddownstreamenzymesintheprostanoidbiosyntheticcascademayrepresentimportantdeterminantsofthefu...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第2期 -
StructuralAnalogofSildenafilIdentifiedasaNovelCorrectoroftheF508del-CFTRTraffickingDefect
...chmoleculecalledKM11060(7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazino}quinoline)wassurprisinglypotent.ItpartiallyrestoredF508deltraffickingandincreasedmaturationsignificantlywhenbabyhamsterkidney(BHK)cellsweretreatedwith10nMfor24hor10µMfor2h.Partialcorrectionwasconfirmedbytheappearanceofm...
医源资料库；在线期刊；分子药理学杂志；2008年第70卷第2期 -
CompleteFcRndependenceforintravenousIgtherapyinautoimmuneskinblisteringdiseases
...ferredtoasBPAg1)isanintracellularproteinthatlocalizestothehemidesmosomalplaque(2,3).Incontrast,BP180(alsoreferredtoasBPAG2ortypeXVIIcollagen)isatransmembraneprotein(4,5).TheextracellularregionofBP180consistsof15collagendomainsseparatedfromoneanotherbynon-collagensequences.BP180-specificautoantibodie...
医源资料库；在线期刊；临床研究杂志；2005年第115卷第12期 -
CXCL1inducedbyprostaglandinE2promotesangiogenesisincolorectalcancer
...lanomas,wedeterminedwhetherCXCL1levelsarealsoincreasedinhumanCRCs.Real-timequantitativePCRandELISAassayswereperformedtomeasureCXCL1levelsinhumancoloncarcinomasatgradeII–IIIcomparedwiththematchednormaltissues.CXCL1mRNAlevelswereelevatedin17of20(85%)cancerspecimens(Fig.1A).CXCL1proteinexpressionwasa...
医源资料库；在线期刊；实验医学杂志；2006年第203卷第4期 -
VEGF-Cpromotessurvivalinpodocytes
...gsolution;5%fetalcalfserumand0.05%Tween20inPBS)beforemountinginVectashieldaqueousmountant(VectorLaboratories).Secondaryantibodieswereappliedconsecutively.Incontrolsections,theprimaryantibodywasreplacedwithnonimmuneimmunoglobulinofthesameclass,species,andconcentration.SectionswereexaminedusingaLeitzD...
医源资料库；在线期刊；美国生理学杂志；2006年第289卷第7期 -
RegulationofLysophosphatidicAcidReceptorExpressionandFunctioninHumanSynoviocytes:ImplicationsforRheumatoidArthritis?
...eisinvolvedinLPA-mediatedcytokinesecretion,whereasLPA-inducedcellmotilityrequiresp38MAPKandRhokinasebutnotp42/44MAPK.TreatmentofFLSwithtumornecrosisfactor-(TNF-)increasesLPA3mRNAexpressionandcorrelateswithenhancedLPA-orOMPT-inducedcytokineproduction.LPA-mediatedsuperproductionofcytokinesbyTNF--prime...
医源资料库；在线期刊；分子药理学杂志；2008年第70卷第2期 -
Aminoacyl-tRNASynthetase-InteractingMultifunctionalProtein/pControlsEndoplasmicReticulumRetentionofHeatShockProteingp
...ftheHSP90family.13LikeotherERresidentproteins,gp96containsaC-terminalKDELsequence,whichisinvolvedinretrogradetransportfromGolgitotheER.14However,despitethisKDELsequence,gp96surfaceexpressionhasbeendemonstratedonmouseMeth-Asarcomacellsbutnotonnormalembryonicfibroblastcells.15Inaddition,ithasbeenrepor...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第6期